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| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 3 | Cyclooxygenase - 1 and 2 - de- pendent prostacyclin formation in patients with atheroselerosis 显示文摘 | Orina B Data B Dermot K | 2002 | Circ2002，102，8： | 1 |
| 4 | subjects obtained with an accelerometric device显示文摘 | AUVINET B BERRUT Reference data for normal G TOUZARD C | 2002 | Gait and Posture2002，16，2： | 1 |
| 5 | Fermentation of biomass-generated producer gas to ethanol显示文摘 | Data R P Shenkman R M Cateni B G | 2004 | Bioteehnology and Bioengineering2004，86，5： | 1 |
| 6 | On k-medoid sets with the aid of a genetic feasibility and comparison显示文摘 | Lucasius C B Dane A clustering of large data algorithm: Background Analytica Chimica Acta D Kateman G | 1993 | 282(3): 647-6691993，282，3： | 1 |
| 7 | A look to the old-world sky: EU- funded dependability cloud computing research 显示文摘 | Alysson B Rudiger K Data P | 2012 | ACM AIGOPS Operating Systems Review2012，46，2： | 1 |
| 8 | Fresh frozen plasma trans- fusion in critically ill medical patients with coagulopathy 显示文摘 | Data S I Rana R Afessa B | 2005 | CritCareMed2005，33，11： | 1 |
| 9 | Cloud microphysical and rainfall responses to zonal perturbations of sea surface temperature:A cloud-resolving modeling study显示文摘The cloud microphysical and rainfall responses to zonal perturbations of sea surface temperature (SST) are investigated by analyzing the equilibrium simulation data (from day 31-40) obtained from a series of two-dimensional cloud-resolving simulations with a zonal model domain of 768 km. Four experiments imposed by zonal SST perturbations of wavenumbers 1 (SST29Z1), 2 (SST29Z2), 4 (SST29Z4), and 8 (SST29Z8) are compared to the control experiment imposed by zonally uniform SST (SST29). The model domain mean SST is 29 °C, and the two-dimensional cloud-resolving model with a cyclic lateral boundary is also imposed by zero vertical velocity and constant zonal wind. The time and model domain mean surface rain rates in SST29Z1, SST29Z2, and SST29Z8 are about 10% larger than those in SST29, whereas the mean surface rain rates in SST29Z4 and SST29 are similar. The analysis of mean surface rainfall budgets shows that local water vapor and hydrometeor changes play important roles in determining the differences and similarities in mean surface rain rate between the perturbation experiments and the control experiment. Both convective and stratiform rain rates are larger in SST29Z1 and SST29Z2 than in SST29 due to the smaller advection of rain from convective regions into raining stratiform regions and the larger vapor condensation rates associated with the larger water vapor convergence over raining stratiform regions in SST29Z1 and SST29Z2. The convective rain rates are larger in SST29Z4 and SST29Z8 than in SST29 because of the larger condensation rates associated with the larger water vapor convergence over convective regions in SST29Z4 and SST29Z8. The stratiform rain rates in SST29Z4 and SST29Z8 are smaller than in SST29 due to the smaller vapor condensation rates and smaller collection rates of cloud water by rain over raining stratiform regions in SST29Z4 and SST29Z8. | Xiaopeng Cuia, Xiaofan Lib, Zhiping Zongc a Laboratory of Cloud-Precipitation Physics and Severe Storms (LACS), Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China b Joint Center for Satellite Data Assimilation and NOAA/NESDIS/Office of Research and Applications, Camp Springs, MD, USA c National Meteorological Center, China Meteorological Administration, Beijing 100081, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 1 |
| 10 | for the Efficient and Robust Large Networks显示文摘 | ZUMBERGE J F HEFLIN Precise Point Positioning Analysis of GPS Data from M B JEFFERSON D C | 1997 | Journal ofGeophysical Research: Solid Earth (1978-2012)1997，102，50： | 1 |
| 11 | in the sioiogical Rat Project显示文摘 | Beard D Neal M Tabesh-Saleki C Bassingtwaighte J Shimoyama Multiscale Virtual Play N Thompson M Carl Modeling and Data Integration son B | 2012 | Ann Biomed Eng2012，40，11： | 1 |
| 12 | -Part IT显示文摘 | Cox E Martin B van Staa T Good research practices forcomparative effectiveness research: approaches to mitigate biasand confounding in the design of non-randomized studies of treatment effects using secondary data sources | 2009 | Value Health2009，12，： | 1 |
| 13 | A look to the old-world sky: EU- funded dependability cloud computing research显示文摘 | Alysson B Rudiger K Data P | 2012 | ACM AIGOPS Operating Systems Review2012，46，2： | 1 |
| 14 | Aloe vera for treating acute and chronic wounds 显示文摘 | DATA D POON F PHAM K B | 2012 | Cochrane Database Syst Rev2012，2，： | 1 |
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