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| 1 | Current research on pharmacologic and regenerative therapies for osteoarthritis显示文摘Osteoarthritis(OA)is a degenerative joint disorder commonly encountered in clinical practice,and is the leading cause of disability in elderly people.Due to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers,OA is a challenging disease with limited treatment options.Traditional pharmacologic therapies such as acetaminophen,non-steroidal anti-inflammatory drugs,and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse events.Current research focuses on the development of new OA drugs(such as sprifermin/recombinant human fibroblast growth factor-18,tanezumab/monoclonal antibody againstβ-nerve growth factor),which aims for more effectiveness and less incidence of adverse effects than the traditional ones.Furthermore,regenerative therapies(such as autologous chondrocyte implantation(ACI),new generation of matrix-induced ACI,cell-free scaffolds,induced pluripotent stem cells(iPS cells or iPSCs),and endogenous cell homing)are also emerging as promising alternatives as they have potential to enhance cartilage repair,and ultimately restore healthy tissue.However,despite currently available therapies and research advances,there remain unmet medical needs in the treatment of OA.This review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations. | Wei Zhang Hongwei Ouyang Crispin R Dass Jiake Xu | 2015 | Bone Research2015，3，4： | 9 |
| 2 | Empyema thoracis: analysis of 150 cases from a teriatry care centre in North East India显示文摘 | Dass R Deak NM Barman H | 2011 | Indian J Pediatr2011，78，11： | 1 |
| 3 | Double Perovskites as Anode Materials for Solid-Oxide Fuel Cells显示文摘 | Huang Y H Dass R I Xing Z L | 2006 | Science2006，312，5771： | 1 |
| 4 | The ophthalmic artery:ⅡBranches显示文摘 | Hayreh S S Dass R | 1962 | Br J Ophthalmol1962，46，： | 1 |
| 5 | Injectable chitosan hydrogels for localised cancer therapy显示文摘 | Ta H T Dass C R Dave E D | 2008 | Journal of Controlled Release2008，126，3： | 1 |
| 6 | Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis 显示文摘 | Davila S Hibberd ML Hari Dass R Wong HE Sahiratmadja E Bonnard C | 2008 | PLoS Genet2008，4，10： | 1 |
| 7 | Recent developmentsin liposomes,microparticles and nanoparticles for protein andpeptide drug delivery显示文摘 | TAN M L CHOONG P F DASS C R | 2010 | Peptides2010，31，1： | 1 |
| 8 | Liposomes containing cationic dimethyl dioetadecyl ammonium bromide: formulation, quality con- trol, and lipofection efficiency 显示文摘 | Dass C R Walker T L Burton M A | 2002 | Drug Deliv2002，9，1： | 1 |
| 9 | Hyponatraemia and hypovolemic shock with tuberculous meningitis显示文摘 | Nagaraj R Murlidharan J | 2003 | Indian J Pediatr2003，70，12： | 1 |
| 10 | Pigment epithelium de- rived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis显示文摘 | Ek E T Dass C R Contreras K G | 2007 | Cancer Gene Ther2007，14，7： | 1 |
| 11 | Role of man-ganese peroxidases and lignin peroxidases of Phanerehaete chrysosporium in the decolorization of kraft bleach plant effluent显示文摘 | Michel F C J Dass B S Gralke E A Adinarayana R C | 1991 | Appl Environ Microbio1991，57，8： | 1 |
| 12 | Double pen>vskites asanode materials for solid - oxide fuel cells 显示文摘 | Huang Y H Dass R I Xing Z L | 2006 | Science2006，312，： | 1 |
| 13 | Can postoperative pulmonary complications after elective cholecystectomy be predicted?显示文摘 | POE R H KALLAY M C DASS T | 1988 | Am J Med Sci1988，295，1： | 1 |
| 14 | Investigating CH4 and N20 emissions from eco-engineering wastewater treatment processes using constructed wetland microcosms显示文摘 | INAMORI R GUI P DASS P | 2007 | Process Biochemistry2007，42，： | 1 |
| 15 | Injectable Chitosan Hydrogels for Localised Cancer Therapy 显示文摘 | Ta H T Dass C R Dunstan D E | 2008 | Journal of Controlled Release2008，126，3： | 1 |
| 16 | The urokinase plasminogen activator receptor as a gene therapy target for cancer 显示文摘 | Pi|lay V Dass C R Choong P F | 2007 | Trends Biotechnol2007，25，1： | 1 |
| 17 | A review of clinical and molecular prognostic factors in osteosareoma显示文摘 | Clark J C M Dass C R Choong P F M | 2008 | Journal of cancer research and clinical oncology2008，134，3： | 1 |
| 18 | Effect of niacin supplementation on rumen metabolites in Murrah buffaloes (Bubalus bubalis ) 显示文摘 | Kumar R Dass R S | 2005 | Asian-Aust J Anim Sci2005，18，1： | 1 |
| 19 | Tensile stress-strain characteristics of lightly cementen sand显示文摘 | Dass R N Yen S C Das B M | 1994 | Geotechnical Testing Joumai1994，17，3： | 1 |
| 20 | Double perovskites as anode materials for solid oxide fuel cells显示文摘 | Huang Y H Dass R I Xing Z L | 2006 | Science2006，312，： | 1 |
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