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| 1 | APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease显示文摘Current evidence shows that apolipoprotein E(APOE), apolipoprotein CI(APOC1) and low density lipoprotein receptor-related protein(LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease. | Qin Zhou Dantao Peng Xinrui Yuan Zeping Lv Shenghang Pang Wenyu Jiang Chuyu Yang Xiaohong Shi Guofang Pang Yige Yang Haiqun Xie Wandong Zhang Caiyou Hu Ze Yang | 2014 | Neural Regeneration Research2014，9，6： | 4 |
| 2 | Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates显示文摘Huntington's disease(HD) is caused by abnormal CAG repeat expansion in the 5′-end of the Huntingtin(HTT) gene.In addition to the canonical C-terminal full-length huntingtin(htt) nuclear export signal,a cytoplasmic localization-related domain(CLRD) in the N-terminus of htt has recently been reported.Here,we analyzed this domain by introducing deletion and substitution mutations in a truncated N-terminal htt protein and subsequently monitored htt expression,aggregation and subcellular localization by immunocytochemistry and Western blot analysis.We demonstrated that Htt4-17 was the essential sequence for htt cytoplasmic localization.We also found that the subcellular distribution of htt was altered when Htt1-17 was mutated to contain amino acids of different charges,suggesting a structural requirement of Htt1-17 for the cytoplasmic localization of htt. Deletion of the first three amino acids did not affect its association with mitochondria.We observed that defective cytoplasmic localization resulted in a reduction of total htt aggregates and increased nuclear aggregates,indicating that the subcellular distribution of the protein might influence the aggregation process.These studies provide new insight into the molecular mechanism of htt aggregation in HD. | YAN YaPing PENG DanTao TIAN Jun CHI JingWei TAN JieQiong YIN XinZhen PU JiaLi XIA Kun ZHANG BaoRong | 2011 | Science China(Life Sciences)2011，54，4： | 4 |
| 3 | Microstructure and mechanical properties of three-dimensional carbon/silicon carbide composites fabricated by chemical vapor infiltration显示文摘 | Yongdong Xu Litong Zhang Laifei Cheng Dantao Yan | 1998 | Carbon1998，，7： | 3 |
| 4 | Trichostatin A Extends the Lifespan of Drosophila melanogaster by Elevating hsp22 Expression显示文摘The level of acetylation of histones in nucleosomes is related to the longevity of yeast and animals. However, the mechanisms by which acetylation and deacetylation affect longevity remain unclear. In present study, we investigated the influence of histone acetylation modification on the expression of hsp22 gene and the lifespan in Drosophila melanogaster using histone deacetylase (HDAC) inhibitor Trichostatin A (TSA). The results showed that TSA could extend the lifespan of Drosophila melanogaster. Furthermore, TSA significantly promoted the hsp22 gene transcription, and affected the chromatin morphology at the locus of hsp22 gene along the polytene chromosome. Present data implicate that TSA may affect the lifespan of Drosophila through changing the level of histone acetylation and influencing the expression of hsp22 gene that is related to aging. | DanTAO JunLU HuiSUN Yan-MeiZHAO Zhi-GenYUAN Xiao-XueLI Bai-QuHUANG | 2004 | Acta Biochimica et Biophysica Sinica2004，36，9： | 2 |
| 5 | Optimization of sample number for Weibull function of brittle materials strength显示文摘 | Xu Yongdong Cheng Laifei Zhang Litong Yan Dantao You Chang | 2001 | Ceramics International2001，27，2： | 1 |
| 6 | Mirror writing in elderly patients with Alzheimer disease and vascular dementia显示文摘BACKGROUND:The results showed that mirror writing(MW)was correlated with the development of written language,so that MW examination may be one of methods to examine the intelligence of elderly people.OBJECTIVE:To study the MW in elderly patients with Alzheimer disease(AD)and vascular dementia(VaD)and take appropriate scale for their evaluation.DESIGN:Taking the written portion of the Chinese Aphasia Examination Scale(1994)for assessment.SETTING:Department of Neurology,Neuropsychological Laboratory,Beijing Hospital.PARTICIPANTS:From March 1998 to January 2001,33 patients with AD,30 patients with VaD admitted into Department of Neurology,Beijing Hospital was enrolled into study.Criteria according to the Diagnostic and Statistical Manual of Mental Disorder,4th edition(DSM-IV),published by the American Psychiatric Association was used to diagnose AD,while criteria according to the National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l' Enseignement en Neurosciences(NINDS-AIREN)and Alzheimer Disease Diagnostic and Treatment Center(ADDCT)were used for diagnosis of VaD.AD group contained 19 males and 14 females aged 60-83 years.Twenty-eight males and 2 females,aged 60-87 years made up the VaD group.The 63 healthy elderly subjects matched on age and education as controls were enrolled into study.The matched controls were categorized AD control(n =33)and VaD control(n =30).All patients and controls were understanding and agree with all items of assessment.METHODS:MW examination,Mini Mental State Examination(MMSE),Hachinski Ischemic Scale,the Global Deterioration Scale(GDS)were examined in all subjects.① Use the written potion of the Chinese Aphasia examination Scale(1994),patient using MW for 91%-100% of dictation had complete MW,those using MW for 51%-90% of dictation had severe MW,those using MW for 11%-50% had moderate MW,those using MW for 1%-10% had mild MW.② According to the MMSE,the patients were considered to have dementia if they were illiterate and had an MMSE score ≤ 17 score or educated time ≤ 6 years and MMSE ≤ 20 score or educated time > 6 years and MMSE ≤ 24 score.③ Using the Hachinski Ischemic Scale to differentiate the AD and VaD,it included 6 items and total 9 scores.> 7 score was VaD,< 4 score was AD and 4-7 score was blended dementia.④ Using the GDS to assess cognitive function:Standard criteria were divided in 7 degrees:1 degree:no impairment of cognition and 7 degree:very severe impairment of cognition.MAIN OUTCOME MEASURES:The data of MW examination,evaluation of MMSE,Hachinski Ischemic Scale and the GDS of all assessed subjects.RESULTS:All 63 cases of AD and VaD and 63 healthy controls were entered for analysis.①Results of MW examination:A total of 17 patients with AD were characterized as using MW,3 with moderate MW and 14 patients with mild MW.In the corresponding control group,only 2 subjects were characterized as being mild MW.The VaD group has 23 patients with MW,2 with moderate and 21 patients with mild MW.② MMSE score:MMSE score of AD group was much lower than that of individuals in control group(20.15± 3.40),(29.73±0.40)score,P < 0.01,MMSE score of VaD group was much lower than that of individuals in control group(19.33±2.75),(29.12±0.63)score,P < 0.01.③ Hachinski Ischemic Scale and GDS score:Rating according to the Hachinski Ischemic Scale was higher in VaD patients compared to AD patients(9.61 ±1.69),(1.09±0.60)score,P < 0.01.The GDS score did not significantly differ between the AD group and the VaD group.CONCLUSION:① MW examination could be used as an indicator of intelligence in healthy elderly people and also could be used as one of methods to assess the intelligence in AD and VaD patients.② Grade of severity of MW may indirectly reflect the degree of dementia. | Xinde Wang Dantao Peng Xiaojie Cai Shuhua Li | 2007 | Neural Regeneration Research2007，2，4： | 1 |
| 7 | Optimization of Sample Number for Weibull Function of Brittle Materials Strength显示文摘 | Xu Yongdong Cheng Laifei Yan Dantao | 2001 | Ceramics International2001，27，2： | 1 |
| 8 | Memantine hydrochloride in the treatment of different dementia subtypes显示文摘 | Dantao Peng Xinrui Yuan Rui Zhu | 2013 | Journal of Clinical Neuroscience2013，，： | 1 |
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