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| 1 | Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration显示文摘AIM:To investigate the effects of transforming growth factorβ1(TGF-β1)on the differentiation of colonic lamina propria fibroblasts(CLPF)into myofibroblasts in vitro. METHODS:Primary CLPF cultures were incubated with TGF-β1 and analyzed for production ofα-smooth muscle actin(α-SMA),fibronectin(FN)and FN isoforms.Migration assays were performed in a modified 48-well Boyden chamber.Levels of total and phosphorylated focal adhesion kinase(FAK)in CLPF were analyzed after induction of migration.RESULTS:Incubation of CLPF with TGF-β1 for 2 d did not changeα-SMA levels,while TGF-β1 treatment for 6 d significantly increasedα-SMA production. Short term incubation(6 h)with TGF-β1 enhanced CLPF migration,while long term treatment(6 d)of CLPF with TGF-β1 reduced migration to 15%-37% compared to untreated cells.FN and FN isoform mRNA expression were increased after short term incubation with TGF-β1(2 d)in contrast to long term incubation with TGF-β1 for 6 d.After induction of migration, TGF-β1-preincubated CLPF showed higher amounts of FN and its isoforms and lower levels of total and phosphorylated FAK than untreated cells. CONCLUSION:Long term incubation of CLPF with TGF-β1 induced differentiation into myofibroblasts with enhancedα-SMA,reduced migratory potential and FAK phosphorylation,and increased FN production.In contrast,short term contact(6 h)of fibroblasts with TGF-β1 induced a dose-dependent increase of cell migration and FAK phosphorylation without induction ofα-SMA production. | Julia Brenmoehl Sandra Nicole Miller Claudia Hofmann Daniela Vogl Werner Falk Jrgen Schlmerich Gerhard Rogler | 2009 | World Journal of Gastroenterology2009，15，12： | 12 |
| 2 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 3 | Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors显示文摘 | Wan Zhihong Zhi Ning Wong Susan Keyvanfar Keyvan Liu Delong Raghavachari Nalini Munson Peter J Su Su Malide Daniela Kajigaya Sachiko Young Neal S | 2010 | Journal of Clinical Investigation2010，，10： | 2 |
| 4 | The quality of life of patients suffering from schizophrenia-acomparison with healthy controls 显示文摘 | Monika S Jan P Daniela J | 2011 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Re- pub2011，155，2： | 1 |
| 5 | Asymbiotic seed germination, in vitro seedling development, and greenhouse acclimatizalion of the threatened terrestrial orchid Bletia purpurea 显示文摘 | Daniela D Timothy R J Philip J K | 2008 | Plant Cell Tiss and Organ Cult2008，94，： | 1 |
| 6 | The Effect of Mn and Si on the Properties of Advanced High Strength Steels Processed by Quenching and Partitioning 显示文摘 | Bohuslav M Hana J Daniela H | 2010 | Materials Science Forum2010，65，： | 1 |
| 7 | The incidence of inflammatory bowel disease in a rural region of Southern Germany: a prospective population-based study显示文摘 | Claudia Ott Florian Obermeier Sabine Thieler Daniela Kemptner Alexandra Bauer Jürgen Sch?lmerich Gerhard Rogler Antje Timmer | 2008 | European Journal of Gastroenterology & Hepatology2008，，9： | 1 |
| 8 | Dendron-mediated self-assembly,disassembl and self-organizationof complex systems显示文摘 | Brad M Rosen Christopher J Wilson Daniela A Wilson | 2009 | Chem Rev2009，109，： | 1 |
| 9 | Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway显示文摘 | Pen J Daniela C Zamescu JA | 2004 | Nature neuroscience2004，7，2： | 1 |
| 10 | The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance显示文摘 | CAROLE B SANDRINE J DANIELA L | 2004 | Int J Biochem Cell Biol2004，36，： | 1 |
| 11 | Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway显示文摘 | Peng J Daniela C Z P Stephanie C | 2004 | Nature neuroscience2004，7，2： | 1 |
| 12 | Granulomatous mastitis显示文摘 | Dagmar Diesing Roland Axt-Fliedner Daniela Hornung Jürgen M. Weiss Klaus Diedrich Michael Friedrich | 2004 | Archives of Gynecology and Obstetrics2004，，4： | 1 |
| 13 | Validation of the personal per- formance (PSP) scale in a german sample of acutely ill patients with schizophrenia 显示文摘 | Georg J Daniela S Nina F | 2008 | Schizophrenia Research2008，，： | 1 |
| 14 | The quality of life of patients suf- fering form Schizophrenia - acomparison with health controls 显示文摘 | Monika S Jan P Daniela J | 2011 | Biomed from Pap Med Fac Uaiv Palacky Olomouc Czech Repub2011，155，2： | 1 |
| 15 | Change to a standardized airway clearance protocol for children with bronchiolitis leads to improved care 显示文摘 | Kristen J Daniela P Kim B | 2014 | Journal of Pediatric Nursing2014，29，3： | 1 |
| 16 | Clinical Safety of SonoVue^TM, aNew Contrst Agent for Ultrasound Imaging,in Healthy Volunteers nd in Patients with Chronic Obstructive Pulmonary Disease显示文摘 | Daniela B John B Peter J | 2002 | Invest Radiol2002，36，2： | 1 |
| 17 | Incidence and risk factors for agranulocytosis in Latin American countries—the Latin Study显示文摘 | Nelson Hamerschlak Eliane Maluf Alexandre Biasi Cavalcanti álvaro Avezum Júnior José Eluf-Neto Roberto Passeto Falc?o Irene Gyongyvér Heidemarie Lorand-Metze Daniel Goldenberg Cézar Leite Santana Daniela de Oliveira Werneck Rodrigues Leny Nascimento da Mo | 2008 | European Journal of Clinical Pharmacology2008，，9： | 1 |
| 18 | Crystal Structure of the Dinuclear Zinc Aminopeptidase PepV from Lactobacillus delbrueckii Unravels Its Preference for Dipeptides 显示文摘 | Daniela J | 2002 | Structure2002，10，： | 1 |
| 19 | Multiple zircon growth during fast exhumation of diamondiferous, deeply subducted continental crust (Kokchetav Massif, Kazakhstan)显示文摘 | J?rg Hermann Daniela Rubatto Andrei Korsakov Vladislav S. Shatsky | 2001 | Contributions to Mineralogy and Petrology2001，，1： | 1 |
| 20 | Granulomatous mastitis显示文摘 | Dagmar Diesing Roland Axt-Fliedner Daniela Hornung Jürgen M. Weiss Klaus Diedrich Michael Friedrich | 2004 | Archives of Gynecology and Obstetrics2004，，4： | 1 |
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