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| 1 | Rapid mitogen-activated protein kinase activation by transforming growth factor α in wounded rat intestinal epithelial cells显示文摘RapidmitogenactivatedproteinkinaseactivationbytransforminggrowthfactorαinwoundedratintestinalepithelialcelsMichaelGkee,Michi... | Michael Gke, Michiyuki Kanai, Kathryn Lynch Devaney, and Daniel K. Podolsky Gastrointestinal Unit, Department of Medicine, and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massa | 1998 | World Journal of Gastroenterology1998，4，3： | 14 |
| 2 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 3 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 4 | Seasonal mean circulation in the Yellow Sea — a model-generated climatology显示文摘 | Christopher E. Naimie Cheryl Ann Blain Daniel R. Lynch | 2001 | Continental Shelf Research2001，，6： | 1 |
| 5 | How Climate and Vegetation Influence the fire Regime of the Alaskan Boreal Biome: The Holocene Perspective显示文摘 | Feng Sheng Hu Linda B. Brubaker Daniel G. Gavin Philip E. Higuera Jason A. Lynch T. Scott Rupp Willy Tinner | 2006 | Mitigation and Adaptation Strategies for Global Change2006，，4： | 1 |
| 6 | The effect of logistics capabilities and strategy on firm performance 显示文摘 | Daniel F Lynch Scott B Keller John Ozment | 2000 | Journal of Business Logistics2000，21，2： | 1 |
| 7 | Venous Thrombosis Associated with the Placement of Peripherally Inserted Central Catheters显示文摘 | Anthony W. Allen Jocelyn L. Megargell Daniel B. Brown Frank C. Lynch Harjit Singh Yuvraj Singh Peter N. Waybill | 2000 | Journal of Vascular and Interventional Radiology2000，，10： | 1 |
| 8 | The effects of logistics capabilities and strategy on firm performance 显示文摘 | Daniel F Lynch Scott B Keller John Ozment | 2000 | Journal of Business Logistics2000，21，2： | 1 |
| 9 | Lipid and Lipoprotein Biomarkers and the Risk of Ischemic Stroke in Postmenopausal Women显示文摘 | Jeffrey S. Berger Aileen P. McGinn Barbara V. Howard Lewis Kuller JoAnn E. Manson Jim Otvos J. David Curb Charles B. Eaton Robert C. Kaplan John K. Lynch Daniel M. Rosenbaum Sylvia Wassertheil-Smoller | 2012 | Stroke2012，，4： | 1 |
| 10 | The Effecrs of Logistics Capabilities and Strategy on Firm Performanee显示文摘 | Daniel F Lynch Scott B Keller John Ozment | 2000 | Journal of Business Logigics2000，21，2： | 1 |
| 11 | The effects of logistics capabilities and strategy on firm performance显示文摘 | DANIEL F LYNCH | 2000 | Journal of Business Logistics2000，21，2： | 1 |
| 12 | Seasonal mean circulation in the Yellow sea-a model generated climatology显示文摘 | Naimie C E Cheryl Ann Blain Daniel R Lynch | 2001 | Continental Shelf Research2001，21，： | 1 |
| 13 | Dilemmas of 'Thought Work' in Fin-de- Siecle China显示文摘 | Lynch Daniel C | 1999 | The China Quarterly1999，157，： | 1 |
| 14 | Communication media selection in buyer-supplier relationships显示文摘 | Eamonn Ambrose Donna Marshall Brian Fynes Daniel Lynch | 2008 | International Journal of Operations & Production Management2008，28，4： | 1 |
| 15 | Venous Thrombosis Associated with the Placement of Peripherally Inserted Central Catheters显示文摘 | Anthony W. Allen Jocelyn L. Megargell Daniel B. Brown Frank C. Lynch Harjit Singh Yuvraj Singh Peter N. Waybill | 2000 | Journal of Vascular and Interventional Radiology2000，，10： | 1 |
| 16 | The effects of logistics capabilities and strategy on firm performance 显示文摘 | Daniel F Lynch Scott B Keller John Ozment | 2000 | Journal of Business Logistics2000，21，2： | 1 |
| 17 | The effects of logistics ca- pabilities and strategy on firm performance显示文摘 | Daniel F Lynch Scott B Keller John Ozment | 2000 | Journal of Business Logistics2000，21，： | 1 |
| 18 | Fine mapping of the chromosome 3p susceptibility locus in inflam- matory bowel disease显示文摘 | Hampe J Lynch NJ Daniels S | 2001 | Gut2001，48，： | 1 |
| 19 | Models of landfill leaching: moisture flow and inorganic strength显示文摘 | William A Straub Daniel R Lynch | 1982 | Journal of Environmental Engineering1982，108，2： | 1 |
| 20 | Examining supply chain relationships:Do buyer and supplier perspectives on collaborative relationships differ显示文摘 | GILBERT N NYAGA JUDITH M WHIPPLE DANIEL F LYNCH | 2010 | Journal of operations management2010，28，2： | 1 |
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