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| 1 | Novel findings and future directions on the genetics of hypertension显示文摘 | Jeannette Simino Dabeeru C. Rao Barry I. Freedman | 2012 | Current Opinion in Nephrology and Hypertension2012，，5： | 1 |
| 2 | Genome-Wide Linkage and Positional Association Analyses Identify Associations of Novel AFF3 and NTM Genes with Triglycerides:The GenSalt Study显示文摘We conducted a genome-wide linkage scan and positional association study to identify genes and variants influencing blood lipid levels among participants of the Genetic Epidemiology Network of Salt-Sensitivity(Gen Salt) study. The Gen Salt study was conducted among1906 participants from 633 Han Chinese families. Lipids were measured from overnight fasting blood samples using standard methods.Multipoint quantitative trait genome-wide linkage scans were performed on the high-density lipoprotein, low-density lipoprotein, and logtransformed triglyceride phenotypes. Using dense panels of single nucleotide polymorphisms(SNPs), single-marker and gene-based association analyses were conducted to follow-up on promising linkage signals. Additive associations between each SNP and lipid phenotypes were tested using mixed linear regression models. Gene-based analyses were performed by combining P-values from singlemarker analyses within each gene using the truncated product method(TPM). Significant associations were assessed for replication among777 Asian participants of the Multi-ethnic Study of Atherosclerosis(MESA). Bonferroni correction was used to adjust for multiple testing.In the Gen Salt study, suggestive linkage signals were identified at 2p11.2-2q12.1 [maximum multipoint LOD score(MML)=2.18 at2q11.2] and 11q24.3-11q25(MML=2.29 at 11q25) for the log-transformed triglyceride phenotype. Follow-up analyses of these two regions revealed gene-based associations of charged multivesicular body protein 3(CHMP3), ring finger protein 103(RNF103),AF4/FMR2 family, member 3(AFF3), and neurotrimin(NTM) with triglycerides(P=4 10 4, 1.00 10 5, 2.00 10 5, and1.00 10 7, respectively). Both the AFF3 and NTM triglyceride associations were replicated among MESA study participants(P=1.00 10 7and 8.00 10 5, respectively). Furthermore, NTM explained the linkage signal on chromosome 11. In conclusion, we identified novel genes associated with lipid phenotypes in linkage regions on chromosomes 2 and 11. | Changwei Li Lydia A.L.Bazzano Dabeeru C.Rao James E.Hixson Jiang He Dongfeng Gu Charles C.Gu Lawrence C.Shimmin Cashell E.Jaquish Karen Schwander De-Pei Liu Jianfeng Huang Fanghong Lu Jie Cao Shen Chong Xiangfeng Lu Tanika N.Kelly | 2015 | Journal of Genetics and Genomics2015，42，3： | 1 |
| 3 | Common Variants in Epithelial Sodium Channel Genes Contribute to Salt Sensitivity of Blood Pressure: The GenSalt Study显示文摘 | Qi Zhao Dongfeng Gu James E. Hixson De-Pei Liu Dabeeru C. Rao Cashell E. Jaquish Tanika N. Kelly Fanghong Lu Jixiang Ma Jianjun Mu Lawrence C. Shimmin Jichun Chen Hao Mei L. Lee Hamm Jiang He | 2011 | Circulation: Cardiovascular Genetics2011，，4： | 1 |
| 4 | Genetic variants in the renin–angiotensin–aldosterone system and salt sensitivity of blood pressure显示文摘 | Dongfeng Gu Tanika N Kelly James E Hixson Jing Chen Depei Liu Ji-chun Chen Dabeeru C Rao Jianjun Mu Jixiang Ma Cashell E Jaquish Treva K Rice Charles Gu Lee Hamm Paul K Whelton Jiang He | 2010 | Journal of Hypertension2010，，6： | 1 |
| 5 | Genetic variants in the renin–angiotensin–aldosterone system and blood pressure responses to potassium intake显示文摘 | Jiang He Dongfeng Gu Tanika N. Kelly James E. Hixson Dabeeru C. Rao Cashell E. Jaquish Jing Chen Qi Zhao Chi Gu Jianfeng Huang Lawrence C. Shimmin Ji-Chun Chen Jianjun Mu Xu Ji De-Pei Liu Paul K. Whelton | 2011 | Journal of Hypertension2011，，9： | 1 |
| 6 | 内皮系统基因与血压改变和高血压发病的关系:盐敏感遗传流行病学研究显示文摘研究者在一个纵向家庭研究中以单标记和新基因为基础的方法探讨内皮系统基因与血压改变和高血压发病率的关系。方法:盐敏感性的遗传流行病学随访研究共纳入633个汉族家庭的1768位成员。使用随机零点血压计,获取基线和随访调查的共9次血压值。 | Fangchao Liu Jiang He Dongfeng Gu Dabeeru C.Rao Jianfeng Huang James E.Hixson Cashell E.Jaquish Jichun Chen Changwei Li Xueli Yang Jianxin Li Treva K.Rice Lawrence C.Shimmin Tanika N.Kelly | 2015 | 中华高血压杂志2015，23，10： | 0 |
| 7 | 中国人基因变异和体力活动的相互作用与血压相关显示文摘维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用,这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列,研究基因变异与体力活动相互作用对血压的影响。方法:根据是否进行体力活动将3142名入选者进行分组(体力活动组与非体力活动组),应用广义估计方程分析收缩压和舒张压与血压调控通路中24个基因表型改变的关系[包括196单核苷酸多态性(single-nucleotide polymorphisms,SNP)]。 | May E.Montasser Lawrence C.Shimmin Charles Gu Tanika N.Kelly Cashell E.Jaquish Treva Rice Dabeeru C.Rao Paul K.Whelton James E.Hixson 罗冬梅 叶鹏 | 2012 | 中华高血压杂志2012，20，2： | 0 |
| 8 | Genetic variants in the ADD1 and GNB3 genes and bloodpressure response to potassium supplementation显示文摘Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes.However,blood pressure(BP)responses to potassium supplementation vary among individuals.This study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to potassium-supplementation.We conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north China.BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer.We identified significant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all P<0.0001)that remained significant after adjustment for multiple comparisons.In participants that were heterozygous or homozygous for the G allele of this marker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A allele.In addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple testing.DBP and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A allele.In summary,our study identified novel associations between genetic variants of the ADD1 gene and BP response to potassium-supplementation,which could have important clinical and public health implications.Future studies aimed at replicating these novel findings are warranted. | Dai-Hai YU De-Pei LIU Lai-Yuan WANG Jing CHEN Cashell E.JAQUISH Dabeeru C.RAO James E.HIXSON Jian-Feng HUANG Chung-Shiuan CHEN Charles GU Ji-Chun CHEN Jie CAO Shu-Feng CHEN Paul K.WHELTON Jiang HE Dong-Feng GU | 2010 | Frontiers of Medicine2010，4，1： | 0 |
| 9 | 中国非糖尿病人群代谢综合征与血压盐敏感性关系:一项饮食干预研究显示文摘背景由于胰岛素抵抗被认为是代谢综合征的潜在机制,因此受累个体可能会对饮食钠干预较为敏感。本文作者旨在研究代谢综合征与血压盐敏感性之间的关系。方法19(16例年龄≥16岁的中国非糖7.8mmol/d)。分尿病人群参与本研究,受试者先接受7d低钠饮食(513mmol/d),随后再接受7d高钠饮食(30析时,将代谢危险因素信息缺失或未完成饮食干预的受试者剔除。在基线及干预过程中每个阶段的第2、5、6、7天分别测量受试者血压.代谢综合征定义为至少具有下列危险因素中的3项:腹型肥胖、血压升高、高甘油三酯、低HDL胆固醇以及高血糖。高盐敏感性定义:低钠饮食干预后血压下降〉5mmHg(1mmHg=0.133kPa)或高钠饮食干预后血压升高〉5mmHg。研究在ClinicaiTrials.gov上的注册编号为NCT00721721。结果在1881例具有完整代谢综合征相关信息的研究对象中,代谢综合征患者为283例。完成低钠饮食干预者为1853例;完成高钠饮食干预者为1845例。经多因素校正后,在低钠和高钠饮食两个阶段干预过程中,代谢综合征患者的血压平均变化均显著高于非代谢综合征人群(P〈0。0001)。此外,盐敏感性风险随个体代谢危险因素的数量增加而升高。与无代谢危险因素的个体相比,在接受低钠饮食干预期间,有4~5个危险因素受试者的高盐敏感性发生风险的OR值增至354(95%CI2.05~6.11);在高钠饮食干预期间,其高盐敏感性发生风险的OR值增至3.13(95%CI1.80~5.43)结论研究结果表明,代谢综合征增强了血压对钠摄入的反应.在对具有多个危险因素的代谢综合征患者进行降压治疗时,减少钠盐摄入应作为一种重要的手段。 | Jing Chen Dongfeng Gu Jianfeng Huang Dabeeru C Rao Cashell E Jaquish James E Hixson Chung-Shiuan Chen Jichun Chen Fanghong Lu Dongsheng Hu Treva Rice Tanika N Kelly L Lee Hamm Paul K Whelton Jiang He 顾东风(译) | 2009 | 世界临床医学2009，，10： | 0 |
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