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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 3 | Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction显示文摘 | Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL | 2014 | Chinese Medical Journal2014，，4： | 23 |
| 4 | 肾周脂肪的产热活性促进肾透明细胞癌的进展并影响肿瘤治疗效果显示文摘肾细胞癌(RCC)是一种常见的致命恶性肿瘤,占所有成人癌症的2%以上,根据组织学和细胞遗传学特征,80%的肾细胞癌被细分为透明细胞肾细胞癌(ccRCC)。肾周脂肪组织(PAT)是一种位于肾筋膜和肾包膜之间的白色脂肪组织(WAT)。在肿瘤发生过程中,ccRCC细胞可穿透肾包膜并进入PAT,与肾癌预后不良相关。然而,ccRCC和PAT之间的相互作用还没有得到很好的研究。研究者通过对ccRCC细胞和PAT之间双向通信的深入探究发现,ccRCC细胞通过旁分泌模式分泌甲状旁腺激素相关蛋白(PTHrP)激活PKA途径驱动邻近的PAT褐变,使褐色变的肾周脂肪细胞代谢增强并释放大量的代谢产物,其中过量的乳酸被释放到肿瘤微环境中,从而促进ccRCC的生长、侵袭和转移,构成了一种新的促进ccRCC肿瘤生长的可能机制。该研究提示肾癌手术中切除邻近脂肪组织可能会阻止褐色脂肪细胞的代谢产物流动,从而改善手术后的预后。 | 杨濛(编译) 张宗勤(编译) Wei G Sun HL Dong K | 2021 | 中华医学杂志2021，101，46： | 6 |
| 5 | WELDING BETWEEN HIGH MANGANESE STEEL AND HIGH CARBON STEEL显示文摘Manuscript received 30 July 1999 Abstract The shielded metal arc welding (SMAW) of a manganese steel part as a crossing of railway track to a carbon steel part as the rails of the railroad is the welding of dissimilar steel. It are was known that it is not possible to the the rail of railroad directly to the cross- ing of railway track made from a steel containing about 14% of manganese (wt. ) because of so many differences between the two kinds of steels such as composition, microstructure,mechanical properties and weldability.A method was used to solve the problem by presetting an intermediate layer on each side of the joint and other special procedures were used.The result of test indicated that a good weld joint was obtained. | M. H. Guo,D. C. Shao, Z. G Dong and J. C Yang National Key Laboratory Advanced Welding Production Technology, Harbin institute of Technology, Harbin 150001, China | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 2 |
| 6 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 7 | Difference of planktonic ciliate communities of the tropical West Pacific, the Bering Sea and the Arctic Ocean显示文摘Ciliates are important components in planktonic food webs,but our understanding of their community structures in different oceanic water masses is limited.We report pelagic ciliate community characteristics in three seas:the tropical West Pacific,the Bering Sea and the Arctic Ocean.Planktonic ciliate abundance had'bimodal-peak','surface-peak'and'DCM(deep chlorophyll a maximum layer)-peak'vertical distribution patterns in the tropical West Pacific,the Bering Sea and the Arctic Ocean,respectively.The abundance proportion of tintinnid to total ciliate in the Bering Sea(42.6%)was higher than both the tropical West Pacific(7.8%)and the Arctic Ocean(2.0%).The abundance proportion of small aloricate ciliates(10–20μm size-fraction)in the tropical West Pacific was highest in these three seas.The Arctic Ocean had higher abundance proportion of tintinnids in larger LOD(lorica oral diameter)size-class.Proportion of redundant species increased from the Arctic Ocean to the tropical West Pacific.Our result provided useful data to further understand ecology roles of planktonic ciliates in different marine habitats. | Chaofeng Wang Haibo Li Zhiqiang Xu Shan Zheng Qiang Hao Yi Dong Li Zhao Wuchang Zhang Yuan Zhao Gérald Grégori Tian Xiao | 2020 | Acta Oceanologica Sinica2020，39，4： | 2 |
| 8 | Tension versus compression superplastic behavior of a Mg-29wt% Li-25wt%B4C composite显示文摘 | WOLFENSTINE J GONZALEZ - DONGE G SHERBY O D | 1992 | Materials Letters1992，15，4： | 1 |
| 9 | Molecular sensing with the tunnel junction of an Au nanogap in solution 显示文摘 | DONG X D XIA Y ZHU G Y | 2007 | Nanotechnology2007，18，39： | 1 |
| 10 | Derivation and characterization of dispersion of defect modes in photonic band gap from stacks of positive and negative index materials显示文摘 | Chen Yihang Liang G Q Dong Jianwen | 2006 | Phys Lett A2006，351，6： | 1 |
| 11 | Variations of horizontal and vertical velocities over two-dimensional transverse dunes: A wind tunnel simulation of the effect of windward slope显示文摘 | Qian G Q Dong Z B Luo W Y | 2009 | Journal of AridEnvironments2009，73，： | 1 |
| 12 | Investigation on POM reaction in a new perovskite membrane reactor 显示文摘 | Dong H Shao Z P Xiong G X | 2001 | Catal Today2001，67，： | 1 |
| 13 | Dietary sodium and potassium,socioeconomic status,and blood pressure in a Chinese population显示文摘 | Tian HG HU G Dong QN | 1996 | Appetite1996，26，3： | 1 |
| 14 | B7-H1, athird member of the B7family, co-stimulates T-cell proliferation and interleukin-10 secretion 显示文摘 | Dong H D Zhu G F Tamada K | 1999 | Nat Med1999，5，12： | 1 |
| 15 | B7-H1 determines accumulation and deletion of intrahepatic CD8^+ T lymphocytes 显示文摘 | Dong H Zhu G Tamada K | 2004 | Immunity2004，20，3： | 1 |
| 16 | Aerodynamic roughness of fixed sandy beds显示文摘 | Dong Z B Wang X M Zhao A G | 2001 | Journal of Geophysical Research2001，106，11： | 1 |
| 17 | Relationships Between Protein Composition and Mixograph and Loaf Characteristics in Wheat 显示文摘 | Dong H Sears R G Cox T S | 1992 | Cereal Chem1992，69，2： | 1 |
| 18 | Adaptive modified function projective synchronization of hyperchaotie systems with unknown parameters 显示文摘 | ZHENG S DONG G G BI Q S | 2010 | Communications in Nonlinear Science and Numerical Simulation2010，15，11： | 1 |
| 19 | On graphs determining links with maximal number of components via medial construction 显示文摘 | JINX A DONG F M TAY E G | 2009 | Discrete Appl Math2009，157，14： | 1 |
| 20 | Attack structuralvulnerability of power grids s a hybrid approach based oncomplex networks显示文摘 | CHEN G DONG Z Y HILL D J | 2010 | Physica A: Statistical Mechanics and ItsApplications2010，389，3： | 1 |
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