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| 1 | Nutritional and vitamin status in patients with neuroendocrine neoplasms显示文摘Symptoms of gastroenteropancreatic located neuroendocrine neoplasms(GEPNENs) are often related to food intake and manifest as abdominal pain or diarrhoea which can influence patients nutritional status. Malnutrition is common in cancer patients and influences quality of life, treatment options and survival but is also present in up to 40% of patients with GEP-NENs. As part of malnutrition there are often deficiencies in fat-soluble vitamins, mainly vitamin D. Little knowledge exists on trace elements. Several factors influence the development of malnutrition such as size and localisation of the primary tumour as well as metastases, side effects from treatment but also hormone production of the tumour itself. One of the main influencing factors leading to malnutrition is diarrhoea which leads to dehydration and electrolyte disturbances. Treatment of diarrhoea should be guided by its cause. Screening for malnutrition should be part of routine care in every GEP-NEN patient. Multidisciplinary treatment including dietician support is necessary for all malnourished patients with GEP-NENs. | Dominique SVM Clement Margot ET Tesselaar Monique E van Leerdam Rajaventhan Srirajaskanthan John K Ramage | 2019 | World Journal of Gastroenterology2019，25，10： | 4 |
| 2 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 3 | Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans,a major facilitator transporter involved in azole resistance显示文摘 | Benedicte R Zuzana K Dominique S | 2006 | Microbiology2006，152，： | 1 |
| 4 | Spalling and pore pressure in HPC at high temperatures显示文摘 | Pierre K Francois Dominique M Daniel Q | 2000 | Cement and Concrete Research2000，30，： | 1 |
| 5 | Unlocking re-flective practice for nurses: Innovations in working with masterof nursing students in Hong Kong显示文摘 | Joanne T Joyce - McCoach Dominique K | 2013 | Nurse Education in Prac-tice2013，，13： | 1 |
| 6 | Two-dimensionalprotein map of an “ale”-brewing yeast strain: proteomedynamics during fermentation显示文摘 | Dominique K Sandra Z Serge P | 2004 | FEMS Yeast Research2004，5，3： | 1 |
| 7 | Inter- conversion between active and inactive TATA-binding protein transcription complexes in the mouse genome 显示文摘 | Mohamed-Amin C Dominique K Igor M | 2012 | Nucleic Acids Research2012，40，4： | 1 |
| 8 | Use of an intramedullary hip-screw compared with a compression hip-screw with a plate for intertrochanteric femoral fracture显示文摘 | Dominique CR Pangiotis K Laurent F | 1998 | J Bone Joint Surg(Am)1998，18，： | 1 |
| 9 | Simultaneous determination of four tobacco-specific N- nitrosamines (TSNA) in human urine显示文摘 | DOMINIQUE K GERHARD S MICHAEL U | 2009 | J Chromatogr B2009，877，： | 1 |
| 10 | Doublecortin is a devel- opmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons 显示文摘 | Flona F Annette K Dominique B | 1999 | Neuron1999，23，2： | 1 |
| 11 | Detection of potential transgenic plant DNA recipients among soil bacteria显示文摘 | Jean M M Dominique B Elizabeth K | 2007 | Environmental Biosafety Research2007，6，1： | 1 |
| 12 | Tetralogy of Fallot with pulmonary atresia, coronary artery- pulmonary artery fistula, and origin of left pulmonary artery from descending aorta: Total correction in infancy 显示文摘 | Dominique RM Bernard K Etienne T | 1993 | J Tnorac Cardiovasc Surg1993，10，： | 1 |
| 13 | Extracting topographic structure from digital elevation data for geographical information system analysis显示文摘 | Jenson K Dominique F O | 1988 | Photogrametric Engineering and Remote Sensing1988，54，11： | 1 |
| 14 | Use of tuf Sequences for Genus-Specific PCR Detection and Phylogenctic Analysis of 28 Streptococcal Species显示文摘 | Francois J P Danbing K Dominique K B | 2004 | Journal of clinical Microbiology2004，42，8： | 1 |
| 15 | Extracting Topographic Structure from Digital Elevation Data for Geographical Information System Analysis 显示文摘 | JENSONT K DOMINIQUE J O | 1988 | Photogrametric Engineering and Remote Sensing1988，54，11： | 1 |
| 16 | Mechanical and metallurgical investigation of martensite-austenite constituents in simulated welding conditions显示文摘 | Emin B Dominique K | 2004 | Materials Processing Technology2004，8792，： | 1 |
| 17 | Use of tuf sequences for genus-specific PCR detection and phylogenetic analysis of 28 streptococcal species显示文摘 | Francois J P Danbing K Dominique K B | 2004 | J Clin Microbiol2004，，8： | 1 |
| 18 | Myocardial Infarction and Coronary Deaths in the World Health Organization MONICA Project: Registration Procedures, Event Rates, and Case-Fatality Rates in 38 Populations From 21 Countries in Four Continents显示文摘 | Hugh Tunstall-Pedoe Kari Kuulasmaa Philippe Amouyel Dominique Arveiler Anna-Maija Rajakangas Andrzej Paj&OV0539 k | 1994 | Circulation1994，，1： | 1 |
| 19 | A structured light vision system for out-of-plane vibration frequencies location of a moving web显示文摘 | Christophe D Dominique K | 2005 | Machine Vision and Applications2005，16，5： | 1 |
| 20 | Expression of estrogen receptor-related receptors, a subfamily of orphan nuclear receptors, as new tumor biomarkers in ovarian cancer cells显示文摘 | Pengming Sun Jalid Sehouli Carsten Denkert Alexander Mustea Dominique K?nsgen Ines Koch Lihui Wei Werner Lichtenegger | 2005 | Journal of Molecular Medicine2005，，6： | 1 |
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