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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Empirical estimation of tail correlation using copulas:application to Asian markets显示文摘 | Cyril C Dominique M G | 2005 | Quantitative Finance2005，5，5： | 1 |
| 3 | Detection of irradiated deepl-Mfrozen foodstuffs by comparison of DEFT and APC counts显示文摘 | Mariel-MPierre Copln Dominique Jehanno and Bourgeois C M | 1993 | Journal of AppLied Bacteriology1993，75，： | 1 |
| 4 | Inter- conversion between active and inactive TATA-binding protein transcription complexes in the mouse genome 显示文摘 | Mohamed-Amin C Dominique K Igor M | 2012 | Nucleic Acids Research2012，40，4： | 1 |
| 5 | Physicochemical changes induced in carp (Cyprinus carpio) fillets by high pressure processing at low temperature 显示文摘 | Amaral S M Dominique C Alain L | 2006 | Innovative Food Science and Emerging Technologies2006，7，： | 1 |
| 6 | Water-solu- ble binders for MCMB carbon anodes for lithium-ion batteries显示文摘 | FABRICE M C SVETI~NA N DOMINIQUE D | 2011 | J Power Sources2011，196，2： | 1 |
| 7 | Changes in quantitative patterns of dead wood in Maritime pine plantations over time显示文摘 | Antoine B Céline M Dominique P | 2008 | Forest Ecology and Management2008，256，5： | 1 |
| 8 | Detection of irradiated deepl -Mfrozen foodstuffs by comparison of DEFT and APC counts显示文摘 | Mariel-MPierre Copln Dominique Jehanno Bourgeois C M | 1993 | Journal of applied bacteriology1993，75，： | 1 |
| 9 | 29Si MAS NMR study of dicalcium silicate: the structural influence of sulfate and alumina stabilizers显示文摘 | LAURENT B CATHERINE B DOMINIQUE M JEAN-PIERRE C BRUNO L H PIERRE C | 1995 | J Am Ceram Soc1995，78，10： | 1 |
| 10 | Virtual sensor: application to vehicle sideslip angle and transversal forces显示文摘 | JOANNY S ALI C DOMINIQUE M | 2004 | IEEE Transactions on Industrial Electronics2004，51，2： | 1 |
| 11 | Assessing the appropriateness of hospitalisation days in a French University Hospital 显示文摘 | Alche-Gautier MJ Dominique M Frederic C | 2004 | International Journal of Health Care Quality Assurance2004，17，23： | 1 |
| 12 | Viridenepoxydiol, a new pentasub- stituted oxiranyldecene produced by Trichoderma viride 显示文摘 | ANTONIO E ANNALISA C LUCIA M FRANCESCO M ANNA A DOMINIQUE M ANDREA M | 2006 | Journal of Agricultural and Food Chemistry2006，54，18： | 1 |
| 13 | Nutrient content of some mushroom species of the genus Termitomyces consumed in Cameroon显示文摘 | GERMA1N K DOMINIQUE C M ALAIN B S | 2003 | Nahrung-Food2003，47，3： | 1 |
| 14 | Nutrient content of some mushroom species of the genus Termitomyces consumed in Cameroon显示文摘 | Germain K Dominique C M Alain B S | 2003 | Nahrung-Food2003，47，3： | 1 |
| 15 | Overexpression and Purification of an Immunologically Reactive His- BIV Capsid Fusion Protein显示文摘 | Dominique B Francois M Valerie C | 1999 | Protein Expr Purif1999，15，： | 1 |
| 16 | Validation of a rapid liquid chromatography tandem mass spectrometric assay for the determination of oetreotide plasma concentrations 显示文摘 | Amaud C Jennifer D Dominique M | 2014 | Clin Bio- ehem2014，47，12： | 1 |
| 17 | A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells 显示文摘 | Dominique C Marcelo H Emmanuel M | 2007 | Blood2007，110，10： | 1 |
| 18 | Inter-conversion between active and inactive TATA-binding protein tran- scription complexes in the mouse genome 显示文摘 | Mohamed-Amin C Dominique K Igor M | 2012 | Nucleic Acids Research2012，40，4： | 1 |
| 19 | Analysis of uncultured amniocytes by comparative genomic hybridization: a prospective prenatal study显示文摘 | VALERE C DOMINIQUE L | 2000 | Prenat Diagn2000，20，2： | 1 |
| 20 | Relationships between plantparasitic nematode community, fallow duration and soil factors the sudano-sahelian area of senegal 显示文摘 | Patrice C Dominique M Thioulouse J | 2005 | Agriculture Ecosystems and Environment2005，，： | 1 |
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