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| 1 | Endoscopic innovations to increase the adenoma detection rate during colonoscopy显示文摘Up to a quarter of polyps and adenomas are missed during colonoscopy due to poor visualization behind folds and the inner curves of flexures,and the presence of flat lesions that are difficult to detect.These numbers may however be conservative because they mainly come from back-to-back studies performed with standard colonoscopes,which are unable to visualize the entire mucosal surface.In the past several years,new endoscopic techniques have been introduced to improve the detection of polyps and adenomas.The introduction of high definition colonoscopes and visual image enhancement technologies have been suggested to lead to better recognition of flat and small lesions,but the absolute increase in diagnostic yield seems limited.Cap assisted colonoscopy and water-exchange colonoscopy are methods to facilitate cecal intubation and increase patients comfort,but show only a marginal or no benefit on polyp and adenoma detection.Retroflexion is routinely used in the rectum for the inspection of the dentate line,but withdrawal in retroflexion in the colon is in general not recommended due to the risk of perforation.In contrast,colonoscopy with the Third-Eye Retroscope?may result in considerable lower miss rates compared to standard colonoscopy,but this technique is not practical in case of polypectomy and is more time consuming.The recently introduced Full Spectrum Endoscopy?colonoscopes maintains the technical capabilities of standard colonoscopes and provides a much wider view of 330 degrees compared to the 170 degrees with standard colonoscopes.Remarkable lower adenoma miss rates with this new technique were recently demonstrated in the first randomized study.Nonetheless,more studies are required to determine the exact additional diagnostic yield in clinical practice.Optimizing the efficacy of colorectal cancer screening and surveillance requires high definition colonoscopes with improved virtual chromoendoscopy technology that visualize the whole colon mucosa while maintaining optimal washing,suction and therapeutic capabilities,and keeping the procedural time as low and patient discomfort as optimal as possible. | Vincent K Dik Leon MG Moons Peter D Siersema | 2014 | World Journal of Gastroenterology2014，20，9： | 6 |
| 2 | The course of cognitive decline in older persons:results from the longitudinal aging study Amsterdam显示文摘 | Comijs HC Dik MG Deeg DJ | 2004 | Dement Geriatr Cogn Disord2004，17，： | 1 |
| 3 | Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults 显示文摘 | Hoogendijk WJ Lips P Dik MG | 2008 | Arch Gen Psychiatry2008，65，5： | 1 |
| 4 | Total cholesterol and oxysterols:early markers for cognitive decline in elderly显示文摘 | Van Den Kommer TN Dik MG Comics HC | | 0，，04： | 1 |
| 5 | Serum inflammatory proteins and cognitive decline in older persons显示文摘 | Dik MG Jonker C Hack CE | 2005 | Neurology2005，64，8： | 1 |
| 6 | ApoE-ε4 is associated with memory decline in cognitively impaired elderly 显示文摘 | Dik MG Jonker C Bouter LM | 2000 | Neurology2000，554，4： | 1 |
| 7 | Stroke and apolipoprotein E-εe independent risk factors for cognitive decline:a population- based study显示文摘 | Dik MG Deeg DJH Bouter LM | 2000 | Stroke2000，31，10： | 1 |
| 8 | Depression is associated with decreased 25-hydroxy-vitamin D and increased parathyroid hormone levels in older adults显示文摘 | Hoogendijk WJ Lips P Dik MG | 2008 | Arch Gen Psychiatry2008，65，5： | 1 |
| 9 | Contribution of metabolic syndrome component s to cognition in older individuals显示文摘 | Dik MG Jonker C Comijs HC | | Diabetes Care0，30，10： | 1 |
| 10 | APOE-4 is associated with memory decline in cognitively impaired elderly 显示文摘 | DIK MG JONKER C BOUTER LM | 2000 | Neurology2000，54，7： | 1 |
| 11 | Serum inflammatory proteins and cog- nitive decline in older persons 显示文摘 | Dik MG Jonker C Hack CE | 2005 | Neurology2005，64，8： | 1 |
| 12 | Total cholesterol and oxysterols: earlymarkers for cognitive decline in elderly? 显示文摘 | van den Kommer TN Dik MG Comijs HC | 2009 | Neurobiology of Aging2009，30，4： | 1 |
| 13 | Total cholesterol and oxysterols:early markers for cognitive decline in elderly显示文摘 | van den Kommer TN Dik MG Comijs HC | | 0，，： | 1 |
| 14 | Inflammatory markers in AD and MCI patients with different biomarker profiles 显示文摘 | Schuitemaker A Dik MG Veerhuis R | 2009 | Neurobiol Aging2009，30，11： | 1 |
| 15 | Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone lev- els in older adults显示文摘 | Hoogendijk WJG Lips P Dik MG | 2008 | Arch Gen Psychiatry2008，65，： | 1 |
| 16 | Role of lipoproteins and inflammation in cognitive decline: do they interact?显示文摘 | van den Kommer TN Dik MG ComUs HC et aI | 2012 | Neurobiol Aging2012，33，1： | 1 |
| 17 | Contribution of metabolic syndrome components to cognition in old individuals显示文摘 | Dik MG Jonker C Comijs HC | 2007 | Diabetes Care2007，30，： | 1 |
| 18 | Depression is asso- ciated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults 显示文摘 | Hoogendijk WJG Lips P Dik MG | 2008 | Arch Gen Psy- chiatry2008，，65： | 1 |
| 19 | Serum inflammatory proteins and cognitive decline in older persons显示文摘 | Dik MG Jonker C Hack CE | 2005 | Neurology2005，64，： | 1 |
| 20 | Contribution of metabolic syndrome components to cognition in older individuals显示文摘 | Dik MG Jonker C Comijs HC | 2007 | Diabet Care2007，30，10： | 1 |
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