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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors显示文摘 | Nishio N Diaconu I Liu H | 2014 | Cancer Research2014，74，18： | 1 |
| 3 | Immunological effects of low-dose cyclophosphamide in cancer patients treated with oncolytic adenovirus 显示文摘 | Cerullo V Diaconu I Kangasniemi L | 2011 | Mol Ther2011，19，9： | 1 |
| 4 | MUC1 in endometriosis and ovarian cancer显示文摘 | Vlad AM Diaconu I Gantt KR | 2006 | Immunol Res2006，36，13： | 1 |
| 5 | Immune re- sponse is an important aspeet of the antitumor effeet produced by a CD40L- encoding oncolytic adenovirus 显示文摘 | DIACONU I CERULLO V HIRVINEN M L | 2012 | Cancer Res2012，72，9： | 1 |
| 6 | Oneolytie immunotherapy of advaneed solid tumors with a CD40L - expressing replicating adenovirus: assessment of safety and immunologic re- sponses in patients 显示文摘 | PESONEN S DIACONU I KANGASNIEMI L | 2012 | Caneer Res2012，72，7： | 1 |
| 7 | Polyacrylamide obtained by plasma-induced polymerization for a possible application in enhanced oil recovery显示文摘 | Chelaru C Diaconu I C Simionescu I | 1998 | Polym Bull(Berlin)1998，40，6： | 1 |
| 8 | Immune response is animportant aspect of the antitumor effect produced by a CD40L - en-coding oncolytic adenovirus显示文摘 | Diaconu I Cerullo V Hirvinen ML | 2012 | Cancer Res2012，72，9： | 1 |
| 9 | GM-CSF-armed vac- cinia virus induces an antitumor immune response显示文摘 | Parviainen S Ahonen M Diaconu I | 2014 | Int J Canc- er2014，10，2： | 1 |
| 10 | immunological effects of low-dose cyclophosphamide in cancer patients treated with onco- lytic adenovirus显示文摘 | Cerullo V Diaconu i Kangasniemi L | 2011 | Mol Ther2011，29，9： | 1 |
| 11 | Armed oneolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors 显示文摘 | Nishio N Diaconu I Liu H | 2014 | Cancer Res2014，74，18： | 1 |
| 12 | MUC1 in endometriosis and ovarian cancer显示文摘 | Vlad AM Diaconu I Gantt KR | 2006 | Immunol Res2006，36，13： | 1 |
| 13 | Current concepts on cardiovas- cular stent devices显示文摘 | Neamtu I Chiriac AP Diaconu A | 2014 | Mini Rev Med Chem2014，14，6： | 1 |
| 14 | Polyacrylamide obtained by plasma - induced polymerization for a possible application in enhanced oil recovery显示文摘 | CHELARU C DIACONU I C SIMIONESCU I | 1998 | Polym Bull (Berlin)1998，40，6： | 1 |
| 15 | Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD- D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors 显示文摘 | Pesonen S Diaconu I Cerullo V | 2012 | Int J Cancer2012，130，8： | 1 |
| 16 | In vivo and in vitro distribution of type 5 and fiber-modified oncolytic adenoviruses in human blood compartments显示文摘 | Escutenaire S Cerullo V Diaconu I | | 0，，02： | 1 |
| 17 | Immunological effects of low-dose cyclophosphamide in cancer patients treated with oncolytic adenovirus显示文摘 | Cerullo V Diaconu I Kangasniemi L | 2011 | Mol Ther2011，19，9： | 1 |
| 18 | A conditional mouse model for human MUC 1-positive endometriosis shows the presence of anti- MUC 1 antibodies and Foxp3+ regulatory T cells 显示文摘 | Budiu RA Diaconu I Chtissluis R | 2009 | Dis Model Mech2009，2，1112： | 1 |
| 19 | GM-CSF-armed vaccinia virus induces an antitumor immune response 显示文摘 | Parviainen S Ahonen M Diaconu I | 2014 | Int J Cancer2014，10，2： | 1 |
| 20 | Gastrointestinal cancer stem cells as targets for innovative immunotherapy显示文摘The role of cancer stem cells in gastrointestinal cancer-associated death has been widely recognized.Gastrointestinal cancer stem cells(GCSCs)are considered to be responsible for tumor initiation,growth,resistance to cytotoxic therapies,recurrence and metastasis due to their unique properties.These properties make the current therapeutic trials against GCSCs ineffective.Moreover,recent studies have shown that targeting stem cell surface markers or stemness associated pathways might have an additional off-target effect on the immune system.Recent advances in oncology and precision medicine have opened alternative therapeutic strategies in the form of cancer immunotherapy.This approach differs from classical anti-cancer therapy through its mechanism of action involving the activation and use of a functional immune system against tumor cells,instead of aiming physically destruction of cancer cells through radio-or chemotherapy.New immunological approaches for GCSCs targeting involve the use of different immune cells and various immune mechanisms like targeting specific surface antigens,using innate immune cells like the natural killer and T cells,T-cell chimeric antigen receptor technology,dendritic cell vaccine,or immune checkpoint inhibitors.In this respect,better understandings of immune regulatory mechanisms that govern anti-tumor response bring new hope in obtaining long-term remission for cancer therapy. | Mihaela Chivu-Economescu Laura G Necula Lilia Matei Denisa Laura Dragu Ana I Neagu Irina Alexiu Coralia Bleotu Carmen Cristina Diaconu | 2020 | World Journal of Gastroenterology2020，26，14： | 1 |
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