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| 1 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 2 | Therapies targeting cancer stem cells: Current trends and future challenges显示文摘Traditional therapies against cancer, chemo- and radiotherapy, have multiple limitations that lead to treatment failure and cancer recurrence. These limitations are related to systemic and local toxicity, while treatment failure and cancer relapse are due to drug resistance and self-renewal, properties of a small population of tumor cells called cancer stem cells(CSCs). These cells are involved in cancer initiation, maintenance, metastasis and recurrence. Therefore, in order to develop efficient treatments that can induce a longlasting clinical response preventing tumor relapse it is important to develop drugs that can specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature associated with CSC phenotype helped with the design of effective treatments. In this review we discuss targeting surface biomarkers, signaling pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps involved in apoptosis resistance, microenvironmental signals that sustain CSCs growth, manipulation of mi RNA expression, and induction of CSCs apoptosis and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. Some of these agents are under evaluation in preclinical and clinical studies, most of them for using in combination with traditional therapies. The combined therapy using conventional anticancer drugs with CSCs-targeting agents, may offer a promising strategy for management and eradication of different types of cancers. | Denisa L Dragu Laura G Necula Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2015 | World Journal of Stem Cells2015，7，9： | 10 |
| 3 | Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters显示文摘BACKGROUND Obesity and diabetes are associated with high levels of oxidative stress.In Romanian patients with obesity and(or)diabetes,this association has not been sufficiently explored.AIM To evaluate oxidative stress in obese and(or)diabetic subjects and to investigate the possible correlations between oxidative stress and anthropometric/biochemical parameters.METHODS Oxidative stress was evaluated from a single drop of capillary blood.Reactive oxygen species(ROS)were evaluated using the free oxygen radical test(FORT).The free oxygen radical defence(FORD)assay was used to measure antioxidant levels.RESULTS FORT levels were higher in obese subjects(3.04±0.36 mmol/L H2O2)vs controls(2.03±0.14 mmol/L H2O2)(P<0.0001).FORD levels were lower in obese subjects(1.27±0.13 mmol/L Trolox)vs controls(1.87±1.20 mmol/L Trolox)(P=0.0072).Obese diabetic subjects had higher FORT values(3.16±0.39 mmol/L H2O2)vs non-diabetic counterparts(2.99±0.33 mmol/L H2O2)(P=0.0233).In obese subjects,FORT values correlated positively with body mass index(BMI)(r=0.48,P=0.0000),waist circumference(WC)(r=0.31,P=0.0018),fasting plasma glucose(FPG)(r=0.31,P=0.0017),total cholesterol(TC)(r=0.27,P=0.0068)and uric acid(r=0.36,P=0.0001).FORD values correlated negatively with BMI(r=-0.43,P=0.00001),WC(r=-0.28,P=0.0049),FPG(r=-0.25,P=0.0130),TC(r=-0.23,P=0.0198)and uric acid(r=-0.35,P=0.0002).In obese diabetic subjects,FORT values correlated positively with BMI(r=0.49,P=0.0034)and TC(r=0.54,P=0.0217).FORD values were negatively associated with BMI(r=-0.54,P=0.0217)and TC(r=-0.58,P=0.0121).CONCLUSION Oxidative stress levels,as measured by the FORT and FORD assays,were higher in obese subjects vs controls.ROS levels were elevated in diabetic obese patients vs obese non-diabetic patients and controls. | Mihnea-Alexandru Găman Mirela Elena Epîngeac Camelia Cristina Diaconu Amelia Maria Găman | 2020 | World Journal of Diabetes2020，11，5： | 3 |
| 4 | Apoptosis is inducedin both drug-s ensitive and multidmg-resistant hepatoma cells bysomatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | BrJ Cancer1999，80，8： | 1 |
| 5 | Apoptosis is induced in both drug - sensitive and multidrug - resistant hepatoma cells by somatostatin analogue TT- 232 显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 6 | Apoptosis is induced in both drug-semitive and multidrug-resist ant hepatoma cells by somatostatin analogue TT-232 显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 7 | Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232 显示文摘 | Diaconu C C Szathmari M Keri G | 1999 | Br J Cancer1999，80，： | 1 |
| 8 | Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 9 | High solids content waterborne acrylic/montmorillonite nanocomposites by miniemulsion polymerization 显示文摘 | DIACONU G PAULIS M LEIZA J R | 2008 | Macromollecular Reaction Engineering2008，2，： | 1 |
| 10 | Concepts for morphing airfoil sections using bi-stable laminated com posite structures显示文摘 | Diaconu C G Weaver P M Mattioni F | | 0，，06： | 1 |
| 11 | Apoptosis is induced in both drug-sensitire and multidrug-resistant hepatoma cells by somatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 12 | Personal and family history of suicidal behaviour is associated with lower peripheral cortisol in depressed outpatients显示文摘 | McGirr A Diaconu G Berlim MT | 2011 | J Affect Disord2011，131，13： | 1 |
| 13 | Feasible region in general design space of lamination parameters for laminated composites显示文摘 | Diaconu C G Sato M Sekine H | 2002 | AIAA journal2002，40，3： | 1 |
| 14 | Dysregulation of the sympathetic nervous system, hypothalamic pituitary-adrenal axis and executive function in individuals at risk for suicide 显示文摘 | MeGirr A Diaconu G Berlim MT | 2010 | J Psychiatry Neurosci2010，35，6： | 1 |
| 15 | Towards the synthesis of high solids content waterborne poly(methyl mcthacrylate-co-butyl acrylate)/ montmorillonite nanocomposites显示文摘 | Diaconu G Paulis M Leiza J R | 2008 | Polymer2008，49，10： | 1 |
| 16 | Concepts for morphing airfoil sections using bi- stable laminated composite structures 显示文摘 | Diaconu Cezar G Weaver Paul M Mattioni Filippo | 2008 | Thin Walled Structures2008，46，6： | 1 |
| 17 | Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，： | 1 |
| 18 | Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 19 | Family history of suicidal behavior predicts impulsive-aggressive behavior levels in psychiatric outpatients 显示文摘 | Diaconu G Turecki G | 2008 | J Affect Disord2008，113，12： | 1 |
| 20 | Macroinitia- tor and modified montmorillonite for the synthesis of acrylic/MMT nanocomposite latexes 显示文摘 | Diaconu G Micusik M Bonnefond A | 2009 | Macromolecules2009，42，9： | 1 |
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