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| 1 | 胆固醇结石病人肝脏胆小管侧膜ATP基因表达差异的研究显示文摘目的:本研究旨在测定比较胆石病人与对照组肝脏胆小管侧膜转运蛋白表达差异,以探讨胆石病发生的分子生物学机制。方法:研究包括20例胆囊胆固醇结石病人和11例无胆石症的对照。测定血清胆固醇和甘油三酯、胆汁胆固醇、胆汁酸和磷脂含量,采用Carey表计算胆汁胆固醇饱和指数。实时定量PCR法测定肝脏胆小管侧膜转运蛋白(ABCG5、ABCG8、ABCBll和ABCB4)mRNA的表达量。结果:胆石组血清胆固醇低于对照组(P<0.05)。胆石组胆汁胆固醇摩尔百分比和胆固醇饱和指数较对照组显著升高(P<0.01)。胆石组肝脏胆小管侧膜胆固醇转运蛋白ABCG5和ABCG8表达高于对照组,且后者差异具有统计学显著性(ABCG5:31.44±3.17Vs25.72±3.27,ABCG8:27.53±3.06vs17.81±2.23)。ABCBll和ABCB4表达在两组间差异无显著性。结论:本研究显示,胆石病主要病理生理异常为胆汁胆固醇过饱和,与肝脏胆小管侧膜胆固醇转运蛋白ABCG5和ABCG8的mRNA表达增加有关。 | 蒋兆彦 韩天权 所广军 袁作彪 姜志宏 商俊 蔡杏兴 Gsta Eggertsen Curt Einarsson 张圣道 | 2005 | 外科理论与实践2005，10，1： | 24 |
| 2 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 3 | Impact of cancer related fatigue on the lives of patients New findings from the Fatigue coalition显示文摘 | Curt G Bteitbart W Cella D | 2000 | The on cologist2000，5，5： | 1 |
| 4 | The WCRP CMIP3 Mutimodel Dataset: A New Era in Climate Change Research 显示文摘 | MEEHL G CURT C THOMAS D | 2007 | BullAmer Meteor Soc2007，88，9： | 1 |
| 5 | Carbonate cement at ion in a sequence- stratigraphic framwork: Upper Cretaceous sandstones,Book Cliffs,Utah-Colorado 显示文摘 | Taylor K G Gawthorpe R L Curt is C D | 2000 | Journal of Sedimentary Research2000，70，2： | 1 |
| 6 | Impact of cancer-related fatigue on the lives of patients:New findings from the fatigue coalition显示文摘 | Curt G A Breitbart W Cella D | 2000 | Oncologist2000，5，5： | 1 |
| 7 | Impact of cancer related fatigue on the lives of patients:New findings from the Fatigue Coalition显示文摘 | Curt G Bteitbart W Cella D | 2000 | Oncologist2000，5，5： | 1 |
| 8 | An antibiotic substance active against certain phytopathogens显示文摘 | CURT Leben KEITT G W | 1948 | Phytopathology1948，38，： | 1 |
| 9 | Impact of cancer related fatigue on the lives of patients:New findings from the Fatigue Coalition 显示文摘 | Curt G Bteitbart W Celia D | 2000 | Oncologist2000，5，5： | 1 |
| 10 | reconstructive technique after endoscopic expanded endonasal approaches, vacular pediele nasoseptal flap 显示文摘 | Hadad G Bassagasteguy L Curt'an RI | 2006 | Laryngoscope2006，116，10： | 1 |
| 11 | Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption显示文摘The etiology of most cases of idiopathic bile acid malabsorption (IBAM) is unknown. In this study, a Swedish family with bile acid malabsorption in three consecutive generations was screened for mutations in the ileal apical sodium-bile acid cotransporter gene (ASBT; gene symbol, SLC10A2) and in the genes for several of the nuclear receptors known to be important for ASBT expression: the farnesoid X receptor (FXR) and peroxisome proliferator activated receptor alpha (PPARa). The patients presented with a clinical history of idiopathic chronic watery diarrhea, which was responsive to cholestyramine treatment and consistent with IBAM. Bile acid absorption was determined using 75Se-homocholic acid taurine (SeHCAT); bile acid synthesis was estimated by measuring the plasma levels of 7a-hydroxy-4-cholesten-3-one (C4). The ASBT, FXR, and PPARa genes in the affected and unaffected family members were analyzed using single stranded conformation polymorphism (SSCP), denaturing HPLC, and direct sequencing. No ASBT mutations were identified and the ASBT gene did not segregate withthe bile acid malabsorption phenotype. Similarly, no mutations or polymorphisms were identified in the FXR or PPARa genes associated with the bile acid malabsorption phenotype. These studies indicate that the intestinal bile acid malabsorption in these patients cannot be attributed to defects in ASBT. In the absence of apparent ileal disease, alternative explanations such as accelerated transit through the small intestine may be responsible for the IBAM. | Marco Montagnani Anna Abrahamsson Cecilia Glman Gsta Eggertsen Hanns-Ulrich Marschall Elisa Ravaioli Curt Einarsson Paul A Dawson | 2006 | World Journal of Gastroenterology2006，12，47： | 1 |
| 12 | Nitrogen isotope rati- os of synthetic and organic sources of nitrate water contamina- tion in Spain 显示文摘 | Curt M D Aguado P Sdnchez G | 2004 | Water Air and Soil Pollution2004，151，： | 1 |
| 13 | Impact of cancer - related fa- tigue on the lives of patients : New findings from the fatigue coalition 显示文摘 | Curt G A Breitbart W Celia D | 2000 | Oneologist2000，5，2： | 1 |
| 14 | Clinical trial design for target-based therapy显示文摘 | Fox E Curt G A Balis F M | 2002 | Oncologist2002，7，40： | 1 |
| 15 | The pharmacology and clinical use ofmethotrexate显示文摘 | Jolivet J Cowan K H Curt G A | 1983 | N Engl J Med1983，309，18： | 1 |
| 16 | An antibiotic substance active against certain phytopathogens显示文摘 | CURT L KEITT G W | 1948 | Phytopathology1948，38，： | 1 |
| 17 | The urban heat island effects at Fairbanks,Alaska显示文摘 | Magee N Curts J Wendler G | 1999 | Theoretical and Applied Climatology1999，64，12： | 1 |
| 18 | Production and properties of Antimycin A from a new streptomyces isolate显示文摘 | LOCKWOOD J L CURT L KEITT G W | 1954 | Phytopathology1954，44，： | 1 |
| 19 | Growth, mortality, and morphological response of European beech and downy oak along a light gradient in sub-Mediterranean forest 显示文摘 | KUNSTLER G CURT T BOUCHAUD M | 2005 | Can J For Res2005，35，7： | 1 |
| 20 | Selection and optimization of microbial hosts for biofuels production 显示文摘 | CURT RF MARCUSCHAMER DK STEPHANOPOULOS G | 2008 | Metabolic Engineering2008，，10： | 1 |
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