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| 1 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 2 | Analysis on impact factor ofShanxi province industrial low carbon[J]显示文摘 | YAO Yu(姚宇) HAN Cuicui(韩翠翠) | 2010 | 新西部2010，，20： | 1 |
| 3 | Electrospun nanofiber/hydrogel composite materials and their tissue engineering applications显示文摘Electrospun nanofiber/hydrogel composites combine the excellent biochemical properties of hydrogel with the biomimetic nature of electrospun fibers,and have attracted widespread attention in the last few years.Besides,nanofiber/hydrogel composites with tunable mechanical properties can mimic the microstructure of extracellular matrix(ECM)of various tissues and the microenvironment of different cells.These features enable electrospun fiber/hydrogel composites have uniquely advantageous for tissue repair.However,a comprehensive review of electrospun fiber/hydrogel composites as tissue engineering scaffolds is still lacking.Thus,this article systematically reviewed the preparation of electrospun fiber/hydrogel composites and their application in tissue engineering.First,the preparation strategies of electrospun fiber/hydrogel composites are classified and discussed.Second,the application of electrospun fiber/hydrogel-based scaffolds in tissue engineering,involving skin,blood vessel,nerve,bone and other tissue engineering,are summarized.Finally,future research directions for functional electrospun fiber/hydrogel scaffold materials are proposed. | Miaomiao Zhang Shixin Xu Ruoying Wang Yongan Che Cuicui Han Wei Feng Chengwei Wang Wen Zhao | 2023 | Journal of Materials Science & Technology2023，，31： | 0 |
| 4 | Lateral organic-inorganic hybrid Vis-NIR photodetectors based on GaN nanowires promoting photogenerated carriers transfer显示文摘The narrow bandgap of the low-energy near-infrared(NIR)polymer would lead to overlap between adjacent energy levels,which is a major barrier to the preparation of Vis-NIR polymer bulk hetero-junction(BHJ)photodetectors with small responsivity and photocurrent.In this study,a high-performance lateral inorganic-organic hybrid photodetector was constructed to eliminate this barrier by combining GaN nanowires(GaN-NWs)with PDPP3T:PC61BM-based BHJ.In stage one,high-quality GaN-NWs were synthesized by the catalyst-free CVD method.The mechanism for controlling GaN-NWs morphology by adjusting the NH3 flow rate was revealed.In stage two,the GaN-NWs with large electron mobility were used to accelerate the transfer of photogenerated carriers in the BHJ layer.Finally,compared with the BHJ device,the BHJ/GaN device demonstrated obvious improvements in responsivity and photocurrent at the wavelength between 400 and 1000 nm.The responsivity and photocurrent increased over 20-fold at the NIR band of 800e900 nm.Besides,owing to the energy level gradient effect,the BHJ/GaN device has a response speed of 7.8/<5.0 ms,which increases over three orders of magnitude than that of the GaN-NWs-based device(tr/tf:7.1/10.9 s).Therefore,the novel device structure proposed in this work holds great potential for preparing high-performance Vis-NIR photodetectors. | Tao Han Zexin Wu Zhilong Deng Xiaofeng Zhang Sidi Yang Cuicui Chen Jiajia Zhu Shufang Ding Chunzhi Jiang | 2022 | Journal of Materiomics2022，8，4： | 0 |
| 5 | Microwave Induced Ethanol Bath Bonding for PMMA Microfluidic Device显示文摘High bonding strength,low deformation and convenient procedure are all very important aspects in the microfluidic device fabrication process. In this paper,an improved microwave induced bonding technology is proposed to fabricate microfluidic device based on methyl methacrylate( PMMA). This method employs pure ethanol as the bonding assisted solvent. The ethanol not only acts as the microwave absorbing material,but also works as the organic solvent in bath. The presented research work has shown that the bonding process can be completed in less than 45 s. Furthermore,the convenient bonding only applies microwave oven,beakers and binder clips. Then,we discuss effects of microwave power,bonding time on bonding strength and deformation of microstructures on PMMA microfluidic device. Finally,a 4 layers micro-mixer has been fabricated using the proposed bonding technique which includes 15 trapezoid micro-channels,9 T-type mix units and an X-type mix unit. Experimental results show that the proposed bonding method have some advantages compared with several traditional bonding technologies,such as hot pressing bonding,ultrasonic bonding and solvent assisted bonding methods in respect of bonding strength,deformation and bonding process. The presented work would be helpful for low coat mass production of multilayer polymer microfluidic devices in lab. | Xiaowei Han Xiaowei Liu Li Tian He Zhang Cuicui Zhuang | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，2： | 0 |
| 6 | Structural properties of residual carbon in coal gasification fine slag and their influence on flotation separation and resource utilization:A review显示文摘Coal gasification fine slag(FS)is a typical solid waste generated in coal gasification.Its current disposal methods of stockpil-ing and landfilling have caused serious soil and ecological hazards.Separation recovery and the high-value utilization of residual carbon(RC)in FS are the keys to realizing the win-win situation of the coal chemical industry in terms of economic and environmental benefits.The structural properties,such as pore,surface functional group,and microcrystalline structures,of RC in FS(FS-RC)not only affect the flotation recovery efficiency of FS-RC but also form the basis for the high-value utilization of FS-RC.In this paper,the characteristics of FS-RC in terms of pore structure,surface functional groups,and microcrystalline structure are sorted out in accordance with gasification type and FS particle size.The reasons for the formation of the special structural properties of FS-RC are analyzed,and their influence on the flotation separation and high-value utilization of FS-RC is summarized.Separation methods based on the pore structural characterist-ics of FS-RC,such as ultrasonic pretreatment-pore-blocking flotation and pore breaking-flocculation flotation,are proposed to be the key development technologies for improving FS-RC recovery in the future.The design of low-cost,low-dose collectors containing polar bonds based on the surface and microcrystalline structures of FS-RC is proposed to be an important breakthrough point for strengthening the flotation efficiency of FS-RC in the future.The high-value utilization of FS should be based on the physicochemical structural proper-ties of FS-RC and should focus on the environmental impact of hazardous elements and the recyclability of chemical waste liquid to es-tablish an environmentally friendly utilization method.This review is of great theoretical importance for the comprehensive understand-ing of the unique structural properties of FS-RC,the breakthrough of the technological bottleneck in the efficient flotation separation of FS,and the expansion of the field of the high value-added utilization of FS-RC. | Rui Han Anning Zhou Ningning Zhang Kaiqiang Guo Mengyan Cheng Heng Chen Cuicui Li | 2024 | International Journal of Minerals,Metallurgy and Materials2024，31，2： | 0 |
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