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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Comparison of MB fraction of creatine kinase mass and troponin I serum levels with necropsy findings in acute myocardial infarction显示文摘 | Costa TN Cassaro Strunz CM Nicolau JC | 2008 | Am J Cardiol2008，101，3： | 1 |
| 3 | The clinical use of platelet - rich plasma in the promotion of bone healing: A systematic re- view 显示文摘 | Griffin XL Smith CM Costa ML | 2009 | Injury2009，40，2： | 1 |
| 4 | Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs 显示文摘 | Simplicio AL Duarte CM Costa MS | 2006 | Int J Pharm2006，308，12： | 1 |
| 5 | Supercritical antisolvent precipiation of PHBV microparticles 显示文摘 | Costa MS Duarte AR Cardoso MM Duart CM | 2007 | Int J Pharm2007，328，1： | 1 |
| 6 | Charge effect on the photo- inactivation of Gram-negative and Gram-positive bacteria by cat- ionic meso-substituted porphyrlns 显示文摘 | Alves E Costa L Carvalho CM | 2009 | BMC Microbial2009，9，： | 1 |
| 7 | Value of combined clinical information and thyroid peroxidase antibodies in pregnancy for the prediction of postpartum thyroid dysfunction 显示文摘 | Mamede da Costa S Sieiro Netto L Coeli CM | 2007 | Am J Reprod Immunol2007，58，4： | 1 |
| 8 | Integrating palliative care content into a new undergraduate nursing curriculum:the Uni- versity of Notre Dame, Australia-Sydney experience 显示文摘 | Ramjan JM Costa CM Hiekman LD | 2010 | Collegian2010，17，2： | 1 |
| 9 | Differential bloodpressure and hormonal effects after glucose and xylose ingestion in chronicautonomic failure显示文摘 | MathiasC J da Costa D F McIntosh CM | 1989 | Clin Sci1989，77，1： | 1 |
| 10 | Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients显示文摘 | Costa E Swinkels DW Laarakkers CM | | 0，，4： | 1 |
| 11 | Comparative evolutionary epi-demiology of dengue virus serotypes显示文摘 | Costa RL Voloch CM Schrago CG | 2012 | Infect Genet Evol2012，12，2： | 1 |
| 12 | Hepeidin ser- um levels and resistance to recombinant human erythropoie- tin therapy in haemodialysis patients 显示文摘 | Costa E Swinkels DW Laarakkers CM | 2009 | Acta Haematol2009，122，4： | 1 |
| 13 | Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release显示文摘 | Lopes CM Sousa Lobo JM Costa P | 2006 | Drug Dev Ind Pkarm2006，32，1： | 1 |
| 14 | Anterior cervical fusion: a biomechanical comparison of 4 techniques: laborato- ry investigation显示文摘 | Galbusera F Bellini CM Costa F | 2008 | J Neurosurg Spine2008，9，5： | 1 |
| 15 | presence of osteoelasl-like muhinucleated giant eells in the bone and nonostotie lesions of Langer- hans cell histioeytosis 显示文摘 | da Costa CE Annels NE Faaij CM | 2005 | Exp Med2005，201，5： | 1 |
| 16 | Value of combined clinical information and thyroid peroxidase antibodies in pregnancy for the prediction of postpartum thyroid dysfunction显示文摘 | Mamede da Costa S Sieiro Netto L Coeli CM | 2007 | Am J Reprod Immunol2007，58，4： | 1 |
| 17 | Improved glycemic control in mice lacking Sglt1 and Sglt2显示文摘 | Powell DR Da Costa CM Gay J | 2013 | Am J Physiol Endocrinol Metab2013，304，2： | 1 |
| 18 | Preventive and therapeutic anti-TNF-ct therapy with pentoxifylline decreases ar- thritis and the associated periodontal co-morbidity in mice 显示文摘 | Queiroz-Junior CM Bessoni RL Costa VV | 2013 | Life Sci2013，93，911： | 1 |
| 19 | Combined assessment of sex-and mutation specific information for risk stratification in type 1 long QT syndrome显示文摘 | Costa J Lopes CM Barsheshet A | 2012 | Heart Rhythm2012，9，89： | 1 |
| 20 | Integrating palliative care content into a new undergraduate nursing curriculum:the university of notre dame,australia-sydney experience显示文摘 | Ramjan JM Costa CM Hickman LD | 2010 | Collegian2010，17，2： | 1 |
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