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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors显示文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs. | Patricia Kuiper Lukas JAC Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 3 | Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer显示文摘Matrix metalloproteinases(MMPs) are implicated in cancer development and progression and are associated with prognosis.Single-nucleotide polymorphisms(SNPs) of MMPs,most frequently located in the promoter region of the genes,have been shown to influence cancer susceptibility and/or progression.SNPs of MMP-1,-2,-3,-7,-8,-9,-12,-13 and-21 and of the tissue inhibitor of metalloproteinases(TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors.The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper. | Alexandra MJ Langers Hein W Verspaget Daniel W Hommes Cornelis FM Sier | 2011 | World Journal of Gastrointestinal Oncology2011，3，6： | 4 |
| 4 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 5 | Determination of arsenic by hydride generation inductively coupled plasma mass spectrometry using a tubular membrane gas-liquid separator显示文摘 | BRANCH S CORNS W T EBDON L | 1991 | Journal of Analytical Atomic Spectrometry1991，6，2： | 1 |
| 6 | Some Multiobjective Optimizers are Better than Others显示文摘 | Corne D W Knowles J | 2003 | Evolutionary Computation2003，11，4： | 1 |
| 7 | Population Pharmacokinetics of Escalating Doses of Caspofungin in a Phase II Study of Patients with Invasive Aspergil osis显示文摘 | Würthwein G Cornely OA Trame MN | | 0，，04： | 1 |
| 8 | In vivo pectoralis muscle force-length behavior during level flight in pigeons(Columba livia)显示文摘 | Biewener A A Corning W R Tobalske B W | 1998 | Journal of Experimental Biology1998，201，12： | 1 |
| 9 | Sand detachment under rains with varying angle of incidence显示文摘 | Erpul G Gabriels D Cornelis W M | 2008 | Catena2008，72，： | 1 |
| 10 | Toll-like receptor 2 plays a role in the Early inflammatory rosponse to murine pneumococcal pneumonia but Does not contribute to antibacterial defense显示文摘 | Knapp S Catharina W Cornelis V | 2004 | J Immunol2004，172，： | 1 |
| 11 | Structural and mechanistic studies of the copper (II)-assisted orthohydroxylation of benzoates by trimethylamine N-oxide 显示文摘 | BULLS W COMBA P CORNELI D | 2002 | J Organometal Chem2002，641，12： | 1 |
| 12 | Approximating the nondomi- hated front using the pareto archived evolution strategy显示文摘 | KNOWLES J D CORNED W | 2000 | Evolutionary Computation2000，8，2： | 1 |
| 13 | Chemical proces- ses affecting the mobility of major, minor and trace elements dur- ing weathering of granitic rocks 显示文摘 | Middelburg J J Cornelis H Woittiez J R W | 1988 | Chemical Geology1988，68，： | 1 |
| 14 | Fire frequency and size distri- bution under natural conditions: a new hypothesis显示文摘 | Ki C Lan Corns G W Yang R C | 1999 | landscape Ecology1999，14，： | 1 |
| 15 | Determination of mercury, selenium, bismuth, arsenic and antimony in human hair by microwave digestion atomic fluorescence spectrometry显示文摘 | Rahman L Corns W Bryce D | 2000 | Talanta2000，52，5： | 1 |
| 16 | Measuring and modeling the soil shrinkage characteristic curve 显示文摘 | CORNELIS W M CORLUY J MEDINA H | 2006 | Geoderma2006，137，： | 1 |
| 17 | Effects of different management practices on the soil-water balance and crop yield for improved dryland farming in the Chinese Loess Plateau显示文摘 | Jin K Cornelis W M Schiettecatte W | 2007 | Soil and Tillage Research2007，96，： | 1 |
| 18 | Approximating the nondominated front using the pareto archived evolution strategy显示文摘 | J D Knowles D W Corne | 2000 | Evolutionary Computation2000，8，2： | 1 |
| 19 | Approximating the nondominated front using the Pareto archived evolution strategy 显示文摘 | Knowles J D Corne D W | 2000 | Evolutionary Computation2000，8，2： | 1 |
| 20 | Preparation of monolithic superparamagnetic nanoparticle-polymer composites using a polymerizable acetylacetonate and magnetite nanoparticles 显示文摘 | Marsh D A Szyndler M W Corn R M | 2012 | Polymer Chemistry2012，3，10： | 1 |
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