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| 1 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 2 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 3 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 4 | Generation of dendritic cells expressing bcr-abl from CD34-positive chronic myeloid leukemia precursor cells 显示文摘 | Willen MS Marion R Cornelis AM | 1997 | Human Immunology1997，53，1： | 1 |
| 5 | Frequent Hypermethylation of the 5 CPG island of E-cadherin in esophageal adenocacinoma显示文摘 | Corn PG Heath EI Heitmiller R | 2001 | Clin Cancer-Res2001，7，9： | 1 |
| 6 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium)显示文摘 | J Nouwen C Cornelis R De Fré M Wevers P Viaene C Mensink J Patyn L Verschaeve R Hooghe A Maes M Collier G Schoeters R Van Cleuvenbergen P Geuzens | 2001 | Chemosphere2001，，4： | 1 |
| 7 | Analyst显示文摘 | Vercoutere K Cornelies R Mees L | 1998 | 123: 965-9691998，123，： | 1 |
| 8 | 显示文摘 | Cornelis FM Sier Stephens R Bizik J | 1998 | Cancer Res1998，58，： | 1 |
| 9 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium) 显示文摘 | NOUWEN J CORNELIS C FRE D R | 2001 | Chemosphere2001，43，： | 1 |
| 10 | In vivo pectoralis muscle force-length behavior during level flight in pigeons(Columba livia)显示文摘 | Biewener A A Corning W R Tobalske B W | 1998 | Journal of Experimental Biology1998，201，12： | 1 |
| 11 | IUPAC guidelines for terms related to chemical speciation and fractionation of elements 显示文摘 | TEMPLETON D M ARIESE F CORNELIS R | 2000 | Pure and Applied Chemistry2000，72，8： | 1 |
| 12 | Health risk assessment of dioxin emissions from municipal waste incinerators:the Neerlandquarter(Wilrijk,Belgium)显示文摘 | Nouwen J Cornelis C De Fré R | | Chemosphere0，，： | 1 |
| 13 | Effects of exenatide on measures ofβ-cell function after 3 years in metformin-treated patients with type 2 diabetes显示文摘 | Bunek MC Cornér A Eliasson B | 2011 | Diabetes Care2011，34，9： | 1 |
| 14 | Selenium speciation from food source to metabolites: a critical review显示文摘 | DUMOLrr E VANHAECKE F CORNELIS R | 2006 | Anal Bioanal Chem2006，385，7： | 1 |
| 15 | The relationship of local and distant failure from endometrial cancer: : defining a clinical paradigm 显示文摘 | Corn BW Lanciano RM DAgostino R | 1997 | Gynecol Oncol1997，66，： | 1 |
| 16 | Chemical proces- ses affecting the mobility of major, minor and trace elements dur- ing weathering of granitic rocks 显示文摘 | Middelburg J J Cornelis H Woittiez J R W | 1988 | Chemical Geology1988，68，： | 1 |
| 17 | One-year treatment with exenatide improves beta-cell function,compared with insulin glargine,in metformin-treated type 2 diabetic patients:a randomized,controlled trial显示文摘 | Bunck MC Diamant M Cornér A | | 0，，： | 1 |
| 18 | Fire frequency and size distri- bution under natural conditions: a new hypothesis显示文摘 | Ki C Lan Corns G W Yang R C | 1999 | landscape Ecology1999，14，： | 1 |
| 19 | Chondromyxoid fibrnma of the skull base invading the occipitocervical junction : re- port of a unique case and discussion显示文摘 | Crocker M Corns R Bodi I | 2010 | Skull Base2010，20，2： | 1 |
| 20 | The Yersinia Ysc-Yop ' type III ' weaponry显示文摘 | CORNELIS G R | 2002 | Nat Rev Mol Cell Biol2002，3，10： | 1 |
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