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| 1 | 抗甲状腺药物的副作用显示文摘抗甲状腺药物是治疗甲状腺功能亢进症的主要方法,尤其是由Graves病所致者。尽管一般情况下抗甲状腺药物是安全的,但是它的副作用限制了某些病人的使用。基于致病的严重程度将副作用分为轻度和严重两种。大剂量他巴唑(methimazole,MMI)(400mg或以上)时所有副作用都常见,但是丙基硫氧嘧啶(propyl-thiouracil,PTU)没有明显的剂量相关性。最常见的轻度副作用有皮疹、关节痛、胃肠不适,常规剂量时发生于5%病人;脱发、涎腺炎、肌病、味觉和嗅觉异常亦有发生。常见的严重副作用是粒细胞减少症的症状明显的多关节炎,严重的系统性腺管炎或药物诱发的狼疮(常见于抗中性粒细胞胞浆抗体阳性者)和PTU相关。他巴唑引起的胆汁淤积性肝毒性反应较PTU引起的潜在的致命肝细胞反应为轻。低凝血酶原血症和胰岛素自身免疫综合征是极少见的严重副作用。学习目的:复习抗甲状腺药物少见的副作用和推荐治疗,尤其是否该终止治疗;了解抗甲状腺药物引起的粒细胞缺乏症的可能机制、临床表现和治疗;比较主要抗甲状腺药物的肝毒性。 | David S Cooper,MD 李玉秀 | 2001 | 世界医学杂志2001，5，10： | 7 |
| 2 | Chemoradiotherapy of locally advanced esophageal cancer : long - term follow - up of a prospective randomized trial( RTOG 85 -01 ) 显示文摘 | Cooper JS Guo MD Herskovic | 1999 | JAMA1999，281，17： | 1 |
| 3 | Immunodeficiency disorders 显示文摘 | Cooper MD Lanier LL Conley ME | 2003 | Hematology Am Soc Hematol Educ Program2003，，： | 1 |
| 4 | Role of advanced glycation end products in diabetic nephropathy显示文摘 | Forbes JM Cooper ME Oldfield MD | 2003 | J Am Soc Nephrol2003，149，83： | 1 |
| 5 | Effect of cobra venom induced inhibition of complement activity on allograft rejection reactions显示文摘 | Gewurz H Clark DS Cooper MD | 1967 | Transplantation1967，5，： | 1 |
| 6 | Chemoradiotherapy of locally advanced esophageal cancer:long-term follow-up of aprospective randomized trial(RTOG 85-01)Radiation Therapy On eology Group显示文摘 | Guo MD Herskovic A | 1999 | JAMA1999，281，17： | 1 |
| 7 | Chemoradiotherapy of loca-lly advanced esophageal cancer:long-term follow-up of a prosp-ective randomized trial(RTOG 85-01)显示文摘 | Cooper JS Guo MD Herskovic A | 1999 | JAMA1999，281，17： | 1 |
| 8 | Chemoradiotherapy of locally advanced esophageal cancer:long-term follow-up of a prospective radomized trial(RTOG85-01)显示文摘 | Cooper JS Gao MD Herskovic A | 1999 | Radiat Ther Oncol1999，281，17： | 1 |
| 9 | Conservative versus liberal red cell transfusion in acute myocardial infarction(the CRIT randomized Pilot Study) 显示文摘 | Cooper HA Rao SV Greenberg MD | 2011 | Am J Cardiol2011，108，8： | 1 |
| 10 | Development of new radiopharmaceuticals based on N-substitution of iminodiacetic acid显示文摘 | Loberg MD Cooper M Harvey E | 1976 | J Nucl Med1976，17，7： | 1 |
| 11 | Primary articular cartilage procedures in the middle-aged knee 显示文摘 | Cooper MT Miller MD | 2003 | Sports Medi Arthrosc Rev2003，11，： | 1 |
| 12 | Chemoradith- erapy of locally esophageal cancer: Long - term follow - up of a prospective randomized trial ( RTOG 8501 ) Radiation Therapy Oncology Group 显示文摘 | Cooper JS Guo MD Herskovic A | 1999 | JAMA1999，281，： | 1 |
| 13 | Chemoradiotherapy of locally advanced esophageal cancer:long-term follow-up of a prospective randomized trial(RTOG85-01)显示文摘 | COOPER JS GUO MD HERSKOVIC A | 1999 | JAMA1999，281，17： | 1 |
| 14 | Chemoradiotherapy of lo- cally advanced esophageal cancer: Long - term follow - up of a pro- spective randomized trial ( RTOG - 8501 ), Radiation Oncology Group显示文摘 | Cooper JS Guo MD Herskovic A | 1999 | AMA1999，281，17： | 1 |
| 15 | The Evolution of Adaptive Immunity显示文摘 | Paneer Z and Cooper MD | 2006 | Annu Rev lmmunol2006，24，： | 1 |
| 16 | Role of advanced glycosylation end products in diabetic nephropathy显示文摘 | Forbes JM Cooper ME Oldfield MD | 2003 | J Am Soc Nephrol2003，14，83： | 1 |
| 17 | Chemoradiatherapy of locally advanced esophageal cancer 显示文摘 | Cooper JS Guo MD Herskovic A | 1999 | JAMA1999，281，： | 1 |
| 18 | Chenoradiotherapy of LocaLLy esophageal cancer: Long-term foLLow-up of a prospective randomized triaL ( RTOG85 - 01 ) 显示文摘 | Cooper JS Guo MD Herskovic A | 1999 | JAMA1999，281，： | 1 |
| 19 | Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care显示文摘 | Williams MD Braun LA Cooper LM | 2004 | Crit Care2004，8，5： | 1 |
| 20 | Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis显示文摘 | Christopher J Cooper MD Timothy P | 2014 | The New England journal of medicine2014，370，1： | 1 |
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