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| 1 | Dietary zinc and metallothionein on small intestinal disaccharidases activity in mice显示文摘AIM: To examine the effect of increasing dietary zinc (Zn) intake and the lack of metallothionein (MT) expression on activity of small intestinal disaccharidases. METHODS: MT-Ⅰ and Ⅱ knockout (MT-/-) and wild-type (MT+/+) female mice at 3.5 wk of age were randomly fed with a diet containing 2 (2 Zn), 15 (15 Zn) or 50 (50 Zn) mg Zn/kg (n = 8/group/genotype) for 5 wk. Small intestinal segments (duodenum, jejunum and ileum) were collected and either fixed in 10% formalin for histological analysis or snap frozen in liquid nitrogen for sucrase, lactase and maltase activity analyses.RESULTS: Plasma Zn was significantly (P < 0.05) lower (33%) in MT-/- compared with MT+/+ mice fed the 2 Zn diet. Villus height and crypt depth were increased by approximately 15% in MT+/+ mice compared with MT-/- mice. Duodenal disaccharidase activities were significantly higher in MT+/+ compared with MT-/- mice particularly in those fed the 2 Zn diet. For the 50 Zn diet, jejunal sucrase and lactase activities were significantly higher in MT-/- (13 313 ± 2314; 4107 ± 364 μmol glucose/well/min/g tissue, respectively) compared with MT+/+ mice (7054 ± 608; 1818 ± 174). Similarly, ileal lactase activities were higher in MT-/- (1480 ± 192) compared with MT+/+ (629 ± 353) mice particularly those fed the 2 Zn diet. CONCLUSION: Increasing dietary Zn has little effect on disaccharidases activity in MT wild-type mice. The presence of MT may enhance morphological and functional development of the gut. | Cuong D Tran Johanna Cool Cory J Xian | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 2 | Transgenic mice expressing human Immuno-Deficiency Virus Type 1 in immune cells develop a severe AIDS-like disease显示文摘 | Hanna Z Kay D G Cool M | 1998 | J Virol1998，72，1： | 1 |
| 3 | Fluoroquinolone treatment of experimental Salmonella enterica serovarTyphimurium DT104 infections in chickens selects for both gyrA mutations and changes in efflux pump gene expression CJ3显示文摘 | Randall L P Eaves D J Cooles S W | 2005 | J Antimicrob Chemother2005，56，2： | 1 |
| 4 | Acute interstitial pneumonitis: case series and review of the literature 显示文摘 | Vourlekis J S Brown K K Cool C D | 2000 | Medicine2000，79，6： | 1 |
| 5 | Chemoenzymatic production of 1, 5-dimethyl-2-piperidone显示文摘 | COOLING F B FAGER S K FALLON R D | 2001 | Journal of Molecular Catalysis B: Enzymatic2001，11，46： | 1 |
| 6 | A tyrosine kinase created by fusion of the PDGRFRA and FIP1L1 genes as a thera- peutic target of imatinib in idiopathic hy- pereosinophilic syndrome 显示文摘 | Cools J DeAngelo D J Gotlib J | 2003 | N Engl J Med2003，348，13： | 1 |
| 7 | Strategic group formation and pe- rformance: The case of the US pharmaceutical industry, 1963-1982显示文摘 | Cool K Schendel D | 1987 | Management Science1987，，33： | 1 |
| 8 | Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants 显示文摘 | Henderson-Smart D J Cools F Bhuta T | 2007 | Cochrane Database Syst Rev2007，18，00： | 1 |
| 9 | Pathophysiology of rheumatoid arthritis显示文摘 | Cooles FA Isaacs D | 2011 | Curr Opin Rheumato12011，23，3： | 1 |
| 10 | Synchrotron photoionization measurements of combustion intermediates:the photoionization efficiency of HONO显示文摘 | Taatjes C A Osborn D L Cool T A | 2004 | Chemical Physics Letters2004，394，： | 1 |
| 11 | Genetic diversity of Pseudomonas solanacearum:Detection of restriction fragment length polymorphisms with DNA probes that specify virulence and the hypersensitive response显示文摘 | COOL D BARLOW E SEQUEIRA L | 1989 | Mol Plant Microbe Interact1989，，2： | 1 |
| 12 | 黑胫病弱毒种Leptosphaeria biglobosa通过不同的信号途径诱导油菜抗性显示文摘 | 刘胜毅 刘仁虎 Akinwunmi O Latunde-Dada Hans Cools Huang Y J Bruce D L Fitt John A Lucas | 2005 | 西北农林科技大学学报(自然科学版)2005，33，B08： | 1 |
| 13 | Structural gene encoding human factor Ⅻ is located at 5q33-qter显示文摘 | NIGLI M Cool D | 1988 | Somat Cell Mol Genet1988，14，： | 1 |
| 14 | Systemic infection and delirium :when cytokines and acetylcholine collide显示文摘 | van Cool WA van de Beek D Eikelenboom P | 2010 | Lancet2010，375，： | 1 |
| 15 | 查看详情显示文摘 | A K Ekaputra G D Prestwich S M Cool D W Hutmacher | | 0，，： | 1 |
| 16 | Effect of N,N-dimethylglycine supplementation in parturition feed for sows on metabolism,nutrient digestibility and reproductive performance显示文摘 | Cools A Maes D Buyse J | 2010 | Animal2010，4，12： | 1 |
| 17 | Retinal detachment following excimer laser显示文摘 | Cooling RJ Lavin MJ Mcleod D | 1997 | Br J Ophthalmol1997，81，： | 1 |
| 18 | Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cellspecific marlcer: evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth 显示文摘 | COOL C D STEWART J S WERAHERA P | 1999 | Am J Pathol1999，155，： | 1 |
| 19 | Elective high fre- quency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants 显示文摘 | Cools F Henderson - Smart D J Offringa M | 2009 | Cochrane Database Syst Rev2009，，00： | 1 |
| 20 | Effects of Strontium on the Physicochemical Characteristics of Hydroxyapatite显示文摘 | S. C. Verberckmoes G. J. Behets L. Oste A. R. Bervoets L. V. Lamberts M. Drakopoulos A. Somogyi P. Cool W. Dorriné M. E. Broe P. C. D’Haese | 2004 | Calcified Tissue International2004，，5： | 1 |
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