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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 3 | Prevention of ventilator associated pneumonia:Current practice in Canadian intensive care units显示文摘 | Heyland D K Cook D J Dodek P M | 2002 | J Crit Care2002，17，3： | 1 |
| 4 | The pathogenesis of turkey rhinotracheitis virus in turkey poults inoculate with the virus alone or together with two stains of bacteria显示文摘 | Cook J K A Ellis M M Huggins M B | 1991 | Avian Pathol1991，20，： | 1 |
| 5 | Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults显示文摘 | Moss M Cook J wesnes K | | 0，，01： | 1 |
| 6 | Pathotyping of Aus- tralian isolates of Marekg disease virus and association of pathogenicity with meq gene polymorphism 显示文摘 | Renz K G Cooke J Clarke N | 2012 | Avian Pathol2012，41，2： | 1 |
| 7 | Retarded differential equations with piecewise constant delays显示文摘 | Cooke K L Wiener J | 1984 | J Math Anal Appl1984，99，： | 1 |
| 8 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 9 | Rela- tionship between sequence variation in the S1 spike protein of infectious bronchitis virus and the extent of cross-protection in vivo显示文摘 | CAVANAGH D ELUS M M COOK J K | 1997 | Avian Pathol1997，26，1： | 1 |
| 10 | Prediction of headcut migration using a deterministic approach 显示文摘 | HANSON G J ROBINSON K M COOK K R | 2001 | Transactions of the ASAE2001，44，3： | 1 |
| 11 | Retarded differential equations with piecewise constant delays显示文摘 | COOKE K L WIENERB J | 1984 | Journal of Mathematical Analysis and Applications1984，99，1： | 1 |
| 12 | Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults显示文摘 | Moss M Cook J Wesnes K | 2003 | Int J Neurosci2003，113，1： | 1 |
| 13 | Development and use of the H strain of avian infectious bronchitis virus from the Netherlands as a vaccine:a review显示文摘 | Bijlenga G Cook J K Gelb J J | 2004 | Avian Pathol2004，33，6： | 1 |
| 14 | Envelope determinants of equine infectious anemia virus vaccine protection and the effects of sequence variation on immune recognition显示文摘 | Tagmyer T L Craigo J K Cook S J | 2008 | J Virol2008，82，8： | 1 |
| 15 | Tumor cell survival signaling by the ERK 1/2 pathways显示文摘 | Balmanno K Cook S J | 2009 | Cell Death Differ2009，16，3： | 1 |
| 16 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 17 | Comparative quantification of Campylobacterjejuni from environmental samples using traditional and molecular biological techniques显示文摘 | Rothrockm J Cook K L Bolster C H | 2009 | Can J Microbiol2009，55，6： | 1 |
| 18 | Avian pneumovirus infections of turkeys and chickens显示文摘 | Cook J K | | 0，，02： | 1 |
| 19 | Stability regions for linear equations with piecewise continuous delays显示文摘 | COOKE K L WIENER J | 1986 | Computers and Mathematics with Applica-tions1986，12，6： | 1 |
| 20 | Asian monsoon failure and megadrought during the last millennium显示文摘 | Cook E R Anchukaitis K J Buckley B M | 2010 | Science2010，328，5977： | 1 |
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