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| 1 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 2 | Soil seed bank changes after forest clearing and agricultural use in Alaska显示文摘 | CONN J S COCHRANE C L DELAPP J A | 1984 | Weed Science1984，32，3： | 1 |
| 3 | Revascularization in treat- ment of mesenteric infarction 显示文摘 | Bergan J J Dean RH Conn JJr | 1975 | Ann Surg1975，182，4： | 1 |
| 4 | CUTE: constrained and unconstrained testing environment显示文摘 | Bongartz J Conn A R Gould N I M | 1995 | ACM Tran Math Software1995，，： | 1 |
| 5 | Basement membranes in urothelial carcinoma显示文摘 | Conn IG Croker J Wallace DM | 1987 | Br J Urol1987，60，： | 1 |
| 6 | Reversible water- solubilization of single-walled carbon nanotubes by polymer wrapping显示文摘 | O'ConnelI M J BouI P Ericson L M | 2001 | Chem Phys Lett2001，342，34： | 1 |
| 7 | Is Everyone in Agreement? An Exploration of Within-group Agreement in Employee Perceptions of the Work Environment显示文摘 | CONN A B SMITH D B | 2001 | Journal of Applied Psychology2001，86，1： | 1 |
| 8 | Preparation of glycyrrhizinic acid, the electrolyte-active principle of liquorice: its effects upon metabolism and upon pituitary-adrenal function in man 显示文摘 | Louis L H Conn J W | 1956 | J Lab Clin Med1956，106，1： | 1 |
| 9 | Sports and recreation re- lated injury episodes in the US population, 1997 -99 显示文摘 | Conn JM Annest JL Gilchrist J | 2003 | Inj Prey2003，9，2： | 1 |
| 10 | Intestinal steatosis in the farm reared sea bass Dicentrarchus labrax显示文摘 | Deplano M Connes R Diaz J P | 1989 | Dis Aquac Org1989，6，： | 1 |
| 11 | The metabolism of aromatic compounds in higher plants显示文摘 | KOUKO L J CONNE E | 1996 | Journal of Biological Chemistry1996，236，： | 1 |
| 12 | Minimization techniques for piecewise differentiable functions: the L~ solu- tion to an overdetermined linear system 显示文摘 | BARTELS R H CONN A R SINCLAIR J W | 1978 | SIAM J Numer Anal1978，15，2： | 1 |
| 13 | Purification and characterization of a naturally occurring vascular endothelial growth factor placenta growth factor heterodimer显示文摘 | Disalvo J Bayne M L Conn G | 1995 | J Biol Chem1995，270，13： | 1 |
| 14 | Revascularization in treatment of mesenteric infarction显示文摘 | Dean RH Conn J Jr | 1975 | Ann Surg1975，182，4： | 1 |
| 15 | Primary aldosteronism, evolving concepts in diagnosis and treatment 显示文摘 | Conn J Celso E | 2004 | Curr Opin Endocrinol Diabetes2004，11，： | 1 |
| 16 | The metabolism of aromatic compounds in higher plants显示文摘 | KOUKOL J CONN E E | 1996 | Journal of Biological Chemistry1996，236，： | 1 |
| 17 | Application of high-power lasers in electronic assembly显示文摘 | Flanagan A Connely A Glynn T J | 1996 | Key Eng Material1996，118，119： | 1 |
| 18 | Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signaling显示文摘 | Noetzel M J Jones CK Conn PJ | 2012 | Discov Med2012，14，： | 1 |
| 19 | Metabotropic glutamate receptors : physiology, pharmacology, and disease 显示文摘 | Niswender C M Conn P J | 2010 | Annu Rev Pharmacol Toxicol2010，50，： | 1 |
| 20 | Intestinal steatosis in the farm reard sea bass Dicentrarchus labrax显示文摘 | Deplano M Connes R Diaz J P | 1989 | Dis Aquac Org1989，6，： | 1 |
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