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| 1 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 2 | Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells显示文摘 | Marie-José Blivet-Van Eggelpo?l Hamza Chettouh Laetitia Fartoux Lynda Aoudjehane Véronique Barbu Colette Rey Sabrina Priam Chantal Housset Olivier Rosmorduc Christèle Desbois-Mouthon | 2012 | Journal of Hepatology2012，，1： | 2 |
| 3 | Continuous glucose monitoring in patients with type 2 diabetes:Why? When? Whom?显示文摘 | MONNIER L COLETTE C BOEGNER C | 2007 | Diabetes Metab2007，33，4： | 1 |
| 4 | Glycemic variability: should we and can we prevent it 显示文摘 | Monnier L Colette C | 2008 | Diabetes Care2008，312，： | 1 |
| 5 | Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)显示文摘 | Monnier L Lapinski H Colette C | 2003 | Diabetes Care2003，26，3： | 1 |
| 6 | Integrating glycaemic vari- ability in the glycaemic disorders of type 2 diabetes: a move to- wards a unified glucose tetrad concept 显示文摘 | Monnier L Colette C Owens DR | 2009 | Diabetes Metab Res Rev2009，25，5： | 1 |
| 7 | Contributions of fasting andpostprandial plasma glucose increments to the overall diurnalhyperglycemia of type 2 diabetic patients: variations withincreasing levels of HbA(lc) 显示文摘 | Monnier L Lapinski H Colette C | 2003 | Diabetes Care2003，26，3： | 1 |
| 8 | Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients显示文摘 | Monnier L Lapinski H Colette C | 2003 | Diabetes Care2003，26，3： | 1 |
| 9 | Morninghyperglycemic excursions: a constant failure in the metaboliccontrol of non- insulin- using patients with type 2 diabetes显示文摘 | Monnier L Colette C Rabasa-Lhoret R | 2002 | Diabetes Care2002，25，4： | 1 |
| 10 | Acute glucose fluctuations and chronic sustained hyperglycemia as risk factors for cardiovascular diseases in patients with type 2 diabetes显示文摘 | Colette C Monnier L | 2007 | Horm Metab Res2007，39，9： | 1 |
| 11 | Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetes patients显示文摘 | Monnier L Lapinski H Colette C | 2003 | Diabetes Care2003，26，3： | 1 |
| 12 | Contributions of fasting and postprandialplasma glucose increments to the overall diurnal hyperglycemia of type 2diabetic patients variations with increasing levels of HbA1c显示文摘 | Monnier L Lapinski H Colette C | 2003 | Diabetes Care2003，26，3： | 1 |
| 13 | Insulin alters nuclear Factor-kappaB and peroxisome proliferator-activated receptor gam- ma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle ceils显示文摘 | De Oliveira C Colette C Monnier L | 2005 | J Lab Clin Med2005，145，3： | 1 |
| 14 | Insulin therapy has a com- plex relationship with measure of oxidative stress in type 2 diabe- tes : a case for further study 显示文摘 | Monnier L Colette C Michel F | 2011 | Diabetes Metab Res Rev2011，27，4： | 1 |
| 15 | Regulation of oxida- tive stress by glycaemic control: evidence for an independ- ent inhibitory effect of insulin therapy 显示文摘 | Monnier L Colette C Mas E | 2010 | Diabetologia2010，53，3： | 1 |
| 16 | Acute glucose fluctuations and chronic sustained hyperglycemia as risk factors for cardiovascular diseases in patients with type 2 diabetes显示文摘 | COLETTE C MONNIER L | 2007 | Horm Metab Res2007，39，： | 1 |
| 17 | The effect of glucose variability on the risk of microvascular complications in type 1 diabetes显示文摘 | Monnier L Colette C I~iter L | 2007 | Diabetes Care2007，30，1： | 1 |
| 18 | Effect of Palmitic Acid on the Electrical Conductivity of Carbon Nanotubes-Epoxy Resin Composites显示文摘 | Sophie B Philippe D Emile P Alain P Christophe L Colette L | 2003 | Macromolecules2003，36，： | 1 |
| 19 | Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients:variations with increasing levels of HbA(1c)显示文摘 | Monnier L Lapinski H Colette C | 2003 | Diabetes Care2003，26，3： | 1 |
| 20 | Glycemic Variability:Should we and can we prevent it显示文摘 | Zonnier L Colette C | 2008 | Diabetes Care2008，31，2： | 1 |
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