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| 1 | Tau-induced neurodegeneration: mechanisms and targets显示文摘The accumulation of hyperphosphorylated tau is a common feature of several dementias. Tau is one of the brain microtubule-associated proteins. Here we discuss tau's functions in microtubule assembly and stabilization and with regard to its interactions with other proteins. We describe and analyze important post-translational modifications: hyperphosphorylation, ubiquitination, glycation, glycosylation, nitration, polyamination, proteolysis, acetylation, and methylation. We discuss how these post-translational modifi cations can alter tau's biological function. We analyze the role of mitochondrial health in neurodegeneration. We propose that microtubules could be a therapeutic target and review different approaches. Finally, we consider whether tau accumulation or its conformational change is related to tau-induced neurodegeneration, and propose a mechanism of neurodegeneration. | Cindy Beharry Leah S. Cohen Jing Di Kawsar Ibrahim Susan Briffa-Mirabella Alejandra del C. Alonso | 2014 | Neuroscience Bulletin2014，30，2： | 6 |
| 2 | Capsule endoscopy in pediatrics: A 10-years journey显示文摘Video capsule endoscopy(CE) for evaluation the esophagus(ECE), small bowel(SBCE) and the colon(CCE) is particularly useful in pediatrics, because this imaging modality does not require ionizing radiation, deep sedation or general anesthesia. The risk of capsule retention appears to be dependent on indication rather than age and parallels the adult experience by indication, making SBCE a relatively safe procedure with a significant diagnostic yield. The newest indication, assessment of mucosal change, greatly enhances and expands its potential benefit. The diagnostic role of CE extends beyond the SB. The use of ECE also may enhance our knowledge of esophageal disease and assist patient care. Colon CCE is a novel minimally invasive and painless endoscopic technique allowing exploration of the colon without need for sedation, rectal intubation and gas insufflation. The limited data on ECE and CCE in pediatrics does not yet allow the same conclusions regarding efficacy; however, both appear to provide safe methods to assess and monitor mucosal change in their respective areas with little discomfort. Moreover, although experience has been limited, the patency capsule may help lessen the potential of capsule retention; and newly researched protocols for bowel cleaning may further enhance CE's diagnostic yield. However, further research is needed to optimize the use of the various CE procedures in pediatric populations. | Salvatore Oliva Stanley A Cohen Giovanni Di Nardo Gianfranco Gualdi Salvatore Cucchiara Emanuele Casciani | 2014 | World Journal of Gastroenterology2014，20，44： | 6 |
| 3 | Transformation of rat inner medullar fibroblasts to myofibroblasts in vitro显示文摘 | Grupp C Lottermoser J Cohen DI | 1997 | Kidney Int1997，52，： | 1 |
| 4 | Transformation of rat inner medullary fibrolastes to myfibrolasts in vitro显示文摘 | Lottermoser J Cohen DI | 1997 | Kidney lnt1997，52，5： | 1 |
| 5 | Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy显示文摘 | Duda DG Cohen KS di Tomaso E | 2006 | J Clin Oncol2006，24，9： | 1 |
| 6 | Isolation of eDNA clones encoding T cell-specific membrane-associated proteins 显示文摘 | Hedriek SM Cohen DI Nielsen EA | 1984 | Nature1984，308，： | 1 |
| 7 | Prevalence of diarrhea- genic Escherichia coli in acute childhood enteritis:a prospective controlled study 显示文摘 | Cohen MB Nataro JP Bernstein DI | 2005 | J Pediatr2005，146，： | 1 |
| 8 | Prevalence of di- arrheagenic Escherichia coli in acute childhood enteritis: a prospective controlled study 显示文摘 | COHEN MB NATARO JP BERNSTEIN DI | 2005 | J Pediat2005，146，1： | 1 |
| 9 | The Use of Contrast-Detail-Dose Evaluation of Image Quality in a CT Scanner显示文摘 | Cohen G Di Bianca F | | 0，，02： | 1 |
| 10 | Coronary artery bypass graft in HIV-1-infected patient:a multicenter case control study显示文摘 | BOCCARA F COHEN A DI ANGELANTONIO E | 2008 | Curr HIV Res2008，6，1： | 1 |
| 11 | Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: Implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy 显示文摘 | Duda DG Cohen KS di Tomaso E | 2006 | Clin Oncol2006，24，9： | 1 |
| 12 | Isolation of cDNA clones encording T cell - specific membrane - associated proteins显示文摘 | Hedrie SM Cohen DI Nielsen EA | 1994 | Nature1994，308，： | 1 |
| 13 | Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy 显示文摘 | Duda DG Cohen KS di Tomaso E et a l | 2006 | J Clin Oncol2006，24，9： | 1 |
| 14 | Prevalence of diarrhe- agenic Escherichia coli in acute childhood enteritis: a prospective controlled study显示文摘 | Cohen MB Nataro JP Bemstein DI | 2005 | J Pediatr2005，146，1： | 1 |
| 15 | C - reactive protein and vascular risk : from March to Jupiter显示文摘 | Di Angelantonio E Cohen A | 2010 | Arch Cardiovasc Dis2010，103，3： | 1 |
| 16 | Strains of streptococcus mutans and streptococcuc sobrinus attach to different pellicle receptors 显示文摘 | Cohen L Hay DI | 1986 | Infect lmmun1986，52，： | 1 |
| 17 | The effect of quinidine on electrical energy required for ventricular defibrillation 显示文摘 | Woolfolk DI Chaffee WR Cohen W | 1996 | Am Heart J1996，72，： | 1 |
| 18 | Isolation of cDNA clones encoding T-cell-specific memberane-associated proteins 显示文摘 | Hendrick SM Cohen DI Nielsen EL | 1984 | Nature1984，308，5955： | 1 |
| 19 | Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients:Implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy显示文摘 | Duda DG Cohen KS di Tomaso E | 2006 | J Clin Oncol2006，24，9： | 1 |
| 20 | Isolation of cDNA clones encoding Tce ll-specific membrane-associated proteins显示文摘 | Hedrick SK Cohen DI Nielsen EA | | 0，，： | 1 |
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