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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | 地理信息系统技术在伤寒发热监测中应用显示文摘目的运用地理信息系统(GIS)技术,了解各居民点发热流行率和评价以医疗机构为哨点的伤寒发热监测系统的敏感性。方法收集医学人口普查数据、疾病监测系统信息数据、现场采集居民居住点全球卫星定位数据等资料,建立GIS系统和以人口为基数的发热监测系统;对所有发热就诊病人进行身份和居住地址确认,并制作各居民点年发热就诊率GIS分布图。结果共采集3776个居民居住的全球定位系统(GPS)定位点,人群发热就诊率为1.11‰,发热就诊人次占总门诊人次的16.3%,监测区内的发热就诊病人占所有发热就诊病人的83.5%。在3种类型的医疗机构中,门诊量以个体门诊类最多,但其发热就诊人次占总门诊人次的比率最低(12.6%)。监测区内发热1d或以上的病人地址和身份(ADDRESS-ID)确认率达到95%。根据居民点年发热就诊率GIS分布图,发热就诊率最高的居民点达到17.81‰,最低为0;发热就诊率高的居民点多集中在城市。结论利用GIS技术可直观准确的了解疾病流行率的分布,可迅速直观的寻找出监测系统中的薄弱环节和推断出可能存在的问题。 | 杨进 董柏青 张杰 廖和壮 梁大斌 吴兴华 司国爱 杨宏徽 Jin Kyung Park R Leon Ochiai Camilo J Acosta Moharmmad Ali John D Clemens | 2007 | 中国公共卫生2007，23，9： | 8 |
| 3 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 4 | Relaxant effect of xenin on rat ileum is mediated by apamin-sensitive neurotensin-type receptors显示文摘 | Clemens A Katsoulis S Nustede R | 1997 | Am J Physiol1997，272，1： | 1 |
| 5 | Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care显示文摘 | Katharine Bushby Richard Finkel David J Birnkrant Laura E Case Paula R Clemens Linda Cripe Ajay Kaul Kathi Kinnett Craig McDonald Shree Pandya James Poysky Frederic Shapiro Jean Tomezsko Carolyn Constantin | 2010 | Lancet Neurology2010，，2： | 1 |
| 6 | Intracranial pressure concerns in lateral skull base surgery 显示文摘 | Clemen R Backous DD | 2007 | Otolaryngol Clin North Am2007，40，3： | 1 |
| 7 | Setting action levels for drinking water: are we protecting our health or our economy (or our backs!)? 显示文摘 | Clemens R David B | 2004 | Science of the Total Environment2004，332，： | 1 |
| 8 | Collinearity and the Use of Latent Root Regression for Combining GNP Forecasts 显示文摘 | Guerard J B Clemen R T | 1989 | Journal of Forecasting1989，8，3： | 1 |
| 9 | Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys显示文摘 | Christopher L Coe Marian Kramer Boldizsár Czéh Elizabeth Gould Alison J Reeves Clemens Kirschbaum Eberhard Fuchs | 2003 | Biological Psychiatry2003，，10： | 1 |
| 10 | Linear constrains and the efficiency of combined foreeasts显示文摘 | Clemen R T | 1986 | Journal of Forecasting1986，5，1： | 1 |
| 11 | Origin of an A-type granite: Experimental constraints显示文摘 | Clemens J D Holloway J R White A J R | 1986 | American Mineralogist1986，71，： | 1 |
| 12 | Adi- pose and liver expression of interleukin (IL)-I family members in morbid obesity and effects of weight loss 显示文摘 | Moschen Alexander R Molnar Clemens Enrich Barbara | 2011 | Molecular Medicine2011，78，： | 1 |
| 13 | Booser im- munization of low- and non-responders after a standard three dose hepatitis B vaccine schedule-results of a post- marketing surveillance显示文摘 | Clemens R Sanger R Kruppenbacher J | 1997 | Vaccine1997，15，4： | 1 |
| 14 | Aggregating point estimates:A flexible modeling approach显示文摘 | Clemen R T Winkler R L | 1993 | Management Science1993，39，： | 1 |
| 15 | Diffusion bonding of γ- TiA1 sheets显示文摘 | Cam G Clemens H Gerling R | 1999 | Intermetallics1999，，7： | 1 |
| 16 | Copula models for aggregating expert opinions显示文摘 | Jouini M N Clemen R T | 1996 | Operations Research1996，44，： | 1 |
| 17 | Clinical experience with an inactivated hepatitis A vaceine显示文摘 | Clemens R Salary A Hepburn A | 1995 | J Infect Dis1995，171，1： | 1 |
| 18 | Effects of the regularconsumption of wholemeal wheat foods on cardiovascular riskfactors in healthy people显示文摘 | Giacco R Clemene G Cipriano D | 2010 | Nutr Metab Cardiovasc Dis2010，20，： | 1 |
| 19 | Recombinant production of a hybrid plasminogen activator composed of sur- factant protein B and low-molecular-weight urokinase显示文摘 | Clemens R Poornima M Malgorzata W | 2008 | J Thromb Haemost2008，100，6： | 1 |
| 20 | Specific interaction of the first three zinc fingers of TF Ⅲ A with the internal control region of the Xenopus 5S RNA gene显示文摘 | LIAO X B CLEMENS K R TENNANT L | 1992 | J Mol Biol1992，223，4： | 1 |
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