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| 1 | Role of autophagy in cholangiocarcinoma:Pathophysiology and implications for therapy显示文摘Cholangiocarcinoma(CCA)is a malignant tumour of the biliary system that originates from the neoplastic transformation of cholangiocytes.CCA is characterized by late diagnosis and poor outcome,with surgery considered as the last option for management.Autophagy is a physiological lysosomal degradation process,essential for cellular homeostasis and ubiquitous in all eukaryotic cells.Several studies have reported a potential involvement of autophagy in cancer,but it remains unclear whether activation of this process represents a survival mechanism of cancer cells.In the present review,we examine the autophagic process and summarize the current knowledge about the involvement of autophagy in the progression of cancer.The link between autophagy and chemoresistance and the use of autophagic markers in diagnosis are also considered in detail.Preliminary evidence shows that the combination of autophagy modulators(activators or inhibitors)with conventional chemotherapeutic agents offers a possible treatment option against signalling pathways that are hyperactivated or altered in CCA.In vitro evidence suggests that combination of chemotherapy agents,such as cisplatin,under activation or inhibition of autophagic processes,in two different CCA cell lines,may improve chemosensitivity and reduce cell survival,respectively.A deeper understanding of these pathways,in both cancer and non-cancer cells,could unveil possible therapeutic targets to treat CCA patients. | Elisabetta Ninfole Claudio Pinto Antonio Benedetti Marco Marzioni Luca Maroni | 2021 | World Journal of Clinical Cases2021，9，22： | 3 |
| 2 | Different Patterns of Recurrence in Gastric Cancer Depending on Lauren’s Histological Type: Longitudinal Study显示文摘 | Daniele Marrelli Franco Roviello Giovanni de Manzoni Paolo Morgagni Alberto Di Leo Luca Saragoni Alfonso De Stefano Secondo Folli Claudio Cordiano Enrico Pinto | 2002 | World Journal of Surgery2002，，9： | 2 |
| 3 | Outbreak of Half disease in the Brazilian Amazon 显示文摘 | Marcelo Cordeiro dos Santos Bernardino Claudio de Albuquerque Rosemary Costa Pinto | 2009 | Rev Panam Salud Publica2009，1，26： | 1 |
| 4 | Fenton's pre-treatment of mature landfill leachate显示文摘 | Antonio Lopez Michele Pagano Angela Volpe Appio Claudio Di Pinto | 2003 | Chemosphere2003，54，： | 1 |
| 5 | Outbreak of Haff disease in the Brazilian Amazon显示文摘 | Marcelo Cordeiro dos Santos Bernardino Claudio de Albuquerque Rosemary Costa Pinto | | 0，，05： | 1 |
| 6 | Clinical and microbiological evaluation of high intensity diode laser adjutant to non-surgical periodontal treatment: a 6-month clinical trial显示文摘 | Vanessa Tubero Euzebio Alves Ana Karina Pinto Andrade Janaita Maria Toaliar Marina Clemente Conde Denise Maria Zezell Silvana Cai Claudio Mendes Pannuti Giorgio Micheli | 2013 | Clinical Oral Investigations2013，，1： | 1 |
| 7 | Accuracy of epicardial electroanatomic mapping and ablation of sustained ventricular tachycardia merged with heart CT scan in chronic Chagasic cardiomyopathy显示文摘 | Bruno Pereira Valdigem Nilton José Carneiro Silva Cristiano Oliveira Dietrich Dalmo Moreira Roberto Sasdelli Ibraim M. Pinto Claudio Cirenza Angelo Amato Vincenzo Paola | 2010 | Journal of Interventional Cardiac Electrophysiology2010，，2： | 1 |
| 8 | Different Patterns of Recurrence in Gastric Cancer Depending on Lauren’s Histological Type: Longitudinal Study显示文摘 | Daniele Marrelli Franco Roviello Giovanni de Manzoni Paolo Morgagni Alberto Di Leo Luca Saragoni Alfonso De Stefano Secondo Folli Claudio Cordiano Enrico Pinto | 2002 | World Journal of Surgery2002，，9： | 1 |
| 9 | Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk显示文摘 | Davide Grassi Livia Ferri Giovambattista Desideri Paolo Di Giosia Paola Cheli Rita Del Pinto Giuliana Properzi Claudio Ferri | 2013 | Current Pharmaceutical Design2013，，13： | 1 |
| 10 | Clinically-Staged T3N0 Rectal Cancer: Is Preoperative Chemoradiotherapy the Optimal Treatment?显示文摘 | Raffaele Lombardi Dajana Cuicchi Carmine Pinto Francesca Fabio Bruno Iacopino Stefano Neri Maria Lucia Tardio Claudio Ceccarelli Ferdinando Lecce Giampaolo Ugolini Sara Pini Piergiorgio Tullio Mario Taffurelli Francesco Minni Andrea Martoni Bruno Cola | 2010 | Annals of Surgical Oncology2010，，3： | 1 |
| 11 | Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis显示文摘 | Rita Del Pinto Davide Pietropaoli Apoorva K. Chandar Claudio Ferri Fabio Cominelli | 2015 | Inflammatory Bowel Diseases2015，，11： | 1 |
| 12 | Role of the phase angle in the prognosis of the cirrhotic patient:15 years of follow-up显示文摘BACKGROUND In 2019,cirrhosis accounted for 2.4%of global deaths.The projection for 2030 is an increase in this index.In recent years,hospitalization costs have escalated by 36%for compensated cirrhosis and 24%for decompensated cirrhosis.Therefore,it is necessary to identify a tool capable of predicting the mortality of these patients according to their clinical condition and consequently extending their survival time.Different studies have shown that the phase angle(PA)can be a feasible method in clinical practice,with the potential to guide assertive patient management in the therapeutic of chronic liver disease.AIM To evaluate the prognostic role of PA in cirrhotic patients over a 15-year followup period.METHODS Retrospective cohort study with 129 cirrhotic patients of both sexes over 18 years old.Diagnosis of cirrhosis by liver biopsy.The first year of data collection was 2007,and data regarding outcomes was collected in 2023.Data were gathered from medical records,such as esophageal varices(EV),EV bleeding,ascites,spontaneous bacterial peritonitis(SBP),encephalopathy,laboratory findings and PA.The cut-off value for the PA was 5.4°,a value described in 2012 by Fernandes et al for 129 patients evaluated in this study and the cut-off points for the Brazilian population presented in percentiles(P),as described by Mattiello et al.The mortality was assessed using the PA percentile through Kaplan-Meier curves and multivariate binary logistic regression models.RESULTS Patients were divided into two groups according to the PA 5.4th(PA>5.4°,n=40;PA≤5.4°,n=89)PA percentile( | Letícia Pereira Pinto Claudio Augusto Marroni Juliana Czermainski Maria Luiza Fernandes Dahlem Randhall B Carteri Sabrina Alves Fernandes | 2023 | World Journal of Methodology2023，13，4： | 0 |
| 13 | Design and Implementation of a Digital PID Temperature Controller for Neonatal Incubator ESVIN显示文摘 | Jose Amadeo Daivalos Pinto Edwin Avila Cordova Claudio Bruno Castillon Levano | 2015 | Journal of Mechanics Engineering and Automation2015，5，3： | 0 |
| 14 | 79&PARK住宅区显示文摘位于G?rdet国家公园边缘,Kullen有意识地塑造了一个尊重且适应环境的形式,并展现出与众不同的社区和壮丽的景色。为直接回应周围环境,建筑的西北和东南角高起至临近周边的高度;而距离公园最远、且本是视野最不好的东北角被拉高以使其拥有公园和港口最壮阔的景色。建筑西南角延伸至最远处的G?rdet国家公园;为了在建筑和自然之间创造一个人性化的柔和边缘,西南角被尽可能地压低. | H■gni Laksáfoss Agata Wozniczka Agne Tamasauskaite Alberto Herzog Borko Nikolic Christin Svensson Claudio Moretti Dominic Black Eva Seo-Andersen Frederik Wegener Gabrielle Nadeau Jacob Lykkefold Aaen Jaime Peiro Suso Jan Magasanik Jesper Boye Andersen Jonas Aars■Larsen Julian Andres Ocampo Salazar Karl Johan Nyqvist Karol Bogdan Borkowski Katarina Mácková Katrine Juul Kristoffer Negendahl Lucian Racovitan Maria Teresa Fernandez Rojo Max Gabriel Pinto Min Ter Lim Narisara Ladawal Schr■der Romea Muryn Ryohei Koike Sergiu Calacean Song He Taylor McNally-Anderson Terrence Chew Thomas Sebastian Krall Tiago Sá Tobias Vall■S■rensen Tore Banke Laurian Ghinitoiu 朱翰林(译) | 2019 | 城市环境设计2019，0，2： | 0 |
| 15 | Conceptualizations, Principles, Guidelines, and Models and Teaching Practice Present in Teacher Training显示文摘 | Claudio Pinto Nunes | 2015 | US-China Education Review(A)2015，5，8： | 0 |
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