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| 1 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 2 | Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas显示文摘 | Eliana Amato Marco dal Molin Andrea Mafficini Jun Yu Giuseppe Malleo Borislav Rusev Matteo Fassan Davide Antonello Yoshihiko Sadakari Paola Castelli Giuseppe Zamboni Anirban Maitra Roberto Salvia Ralph H Hruban Claudio Bassi Paola Capelli Rita T Lawlor Mi | 2014 | J. Pathol2014，，3： | 2 |
| 3 | MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer显示文摘 | Nicola Valeri Chiara Braconi Pierluigi Gasparini Claudio Murgia Andrea Lampis Viola Paulus-Hock Jonathan R. Hart Lynn Ueno Sergei I. Grivennikov Francesca Lovat Alessio Paone Luciano Cascione Khlea M. Sumani Angelo Veronese Muller Fabbri Stefania Carasi H | 2014 | Cancer Cell2014，，： | 2 |
| 4 | Caspase - 2 can trigger cytochrome c release and apoptosis from the nucleus显示文摘 | Gabriela P Clare H Claudio S | 2002 | J Biol Chem2002，277，15： | 1 |
| 5 | Variational inequalities for φ-pseudocontractive mappings显示文摘 | Claudio H Morales | | 0，，02： | 1 |
| 6 | Asymptotic periodicity for some evolution equations in Banach spaces显示文摘 | Agarwal R P Cuevas Claudio Soto H El-Gebeily M | | 0，，05： | 1 |
| 7 | A molecular compendium of genes expressed in multiple myeloma 显示文摘 | Claudio JO Masih-Khan E Tang H | 2002 | Blood2002，100，： | 1 |
| 8 | Heterogeneous and homogeneous catalytic ozonation of benzothiazole promoted by activated carbon:Kinetic approach显示文摘 | Héctor V Claudio A Z | 2006 | Chemosphere2006，65，： | 1 |
| 9 | Web-based security cost analysis in electricity markets 显示文摘 | CHEN H CLAUDIO A C AJIT S | 2005 | IEEE Transactions on Power Systems2005，20，2： | 1 |
| 10 | Implant -retained mandibular overdentures with immediate loading: A prospective study of ITI implants 显示文摘 | Claudio G Wemer H Matteo C | 2000 | lnt J Oral Maxillofac Implants2000，15，3： | 1 |
| 11 | Cardiaorenal syndrome显示文摘 | CLAUDIO R MIKKO H ANDREW A | 2008 | J Am Coll Cardiol2008，52，： | 1 |
| 12 | Polyurethane/polyethersulphone composite hollow fibers produced by simult-aneouss pinning of two polymer solutions显示文摘 | Luciana T D Cristina C P Claudio H etal | 2008 | J Membr Sci2008，311，： | 1 |
| 13 | Vaccine-associated paralytic poliomyelitis in Brazil,1989-1995显示文摘 | Lucia H Claudio J | 2000 | Pan Am J Public Health2000，7，4： | 1 |
| 14 | Glycerol acetals as anti- freezing additives for biodiesel显示文摘 | Paulo H R Valter L C Claudio J A | 2010 | Bioresource technology2010，101，15： | 1 |
| 15 | Chronic inflammation andsusceptibility to bacterial infections in mice lacking the polypeptide (p) 105 precursor (NF-κB) but expressing p50显示文摘 | lshikawa H Claudio E Dambach D | | 0，，8： | 1 |
| 16 | Role of hepatitis B virus in development of hepatocellular carcinoma:Focus on covalently closed circular DNA显示文摘Chronic infection with hepatitis B virus(HBV)remains a major global health problem,especially in developing countries.It may lead to prolonged liver damage,fibrosis,cirrhosis,and hepatocellular carcinoma.Persistent chronic HBV infection is related to host immune response and the stability of the covalently closed circular DNA(cccDNA)in human hepatocytes.In addition to being essential for viral transcription and replication,cccDNA is also suspected to play a role in persistent HBV infections or hepatitis relapses since cccDNA is very stable in non-dividing human hepatocytes.Understanding the pathogenicity and oncogenicity of HBV components would be essential in the development of new diagnostic tools and treatment strategies.This review summarizes the role and molecular mechanisms of HBV cccDNA in hepatocyte transformation and hepatocarcinogenesis and current efforts to its detection and targeting. | Claryssa Bianca Elizabeth Sidhartha Claudio Tiribelli Korri Elvanita El-Khobar Caecilia H C Sukowati | 2022 | World Journal of Hepatology2022，14，5： | 1 |
| 17 | Implant-retained mandi bular overdentures with immediate loading: A prospective study of ITI implants显示文摘 | Claudio G Werner H Matteo C | 2000 | Int J Oral Maxillofac Implants2000，15，： | 1 |
| 18 | Is Aeolian Risk as Significant as Other Environmental Risks?显示文摘 | Augusti G Claudio B Niemann H J | 2001 | Reliability Engineering and System Safety2001，74，3： | 1 |
| 19 | Comparison of performance indices for detection of proximity to voltage collapse显示文摘 | Claudio A Canizares Antonio C Z Desouza Victor H Quintana | 1996 | IEEE Trans on Power Systems1996，11，3： | 1 |
| 20 | Structural analysis of metal hydride-based hybrid hydrogen storage systems显示文摘 | CLAUDIO C BRUCE J H DONALDL A | 2012 | International Journal of Hydrogen Energy2012，37，14： | 1 |
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