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13篇 您的检索式:作者名="Chua TM"
    题名 作者 年代 出处 被引量
1Rabeprazole vs esomeprazole in non-erosive gastro-esophageal reflux disease: A randomized, double-blind study in urban Asia显示文摘AIM:Gastro-esophageal reflux disease (GERD) is becoming increasingly common in Asia. Data on the efficacy of proton pump inhibitors in patients with non-erosive GERD (NERD)in Asia is lacking. This double-blind study compared the efficacy and safety of rabeprazole with esomeprazole in relief of symptoms in patients with NERD.METHODS: One hundred and thirty-four patients with reflux symptoms of NERD and normal endoscopy were randomized to receive rabeprazole 10 mg or esomeprazole 20 mg once daily for 4 wk. Symptoms were recorded in a diary and changes in severity of symptoms noted.RESULTS: At 4 wk of treatment, rabeprazole 10 mg and esomeprazole 20 mg were comparable with regards to the primary endpoint of time to achieve 24-h symptomfree interval for heartburn 8.5 d vs9 d and regurgitation 6 d vs 7.5 d. Rabeprazole and esomeprazole were also similarly efficacious in term of patient's global evaluation with 96% of patients on rabeprazole and 87.9% of patients on esomeprazole, reporting that symptoms improved(P=NS). Satisfactory relief of day- and night-time symptoms was achieved in 98% of patients receiving rabeprazole and 81.4% of patients receiving esomeprazole. Adverse events were comparable in both groups (P = NS).CONCLUSION: Rabeprazole 10 mg has a similar efficacy and safety profile in Asians with NERD as esomeprazole 20 mg. Further study is necessary to investigate whether the small differences between the two drugs seen in this study are related to the improved pharmacodynamicpro perties of rabeprazole. Both drugs were well tolerated.KM Fock EK Teo TL Ang TS Chua TM Ng YL Tan 2005World Journal of Gastroenterology2005,11,20:8
2Performance evaluation of five detection tests for influenza antigen with various avian sampies显示文摘Chua TH Ellis TM Wong CW 2007Avian Dis2007,51,1:1
3Numerical study of biocentrifugal blood pump with straight impeller blade profiles显示文摘Song GL Chua LP Lim TM 0,,02:1
4Performance evaluation of five detection tests for avian influenza antigen with various avian samples显示文摘Chua TH Ellis TM Wong C W 2007Avian Dis2007,51,1:1
5Direct intrauterine fetal therapy in a case of bronchopulmonary sequestration associated with non-immune hydrops fetalis显示文摘Anandakumar C Biswas A Chua TM 1999Ultrasound Obstet Gynecol1999,13,4:1
6Numerical simulation of an axial blood pump显示文摘Chua LP Su B Lim TM 2007Artif Organs2007,31,7:1
7Epinephrine injection therapy versus a combination of epinephrine injection and endoscopic hemoclip in the treatment Gastroenterol, 2005,11 : 1044 of bleeding ulcers 显示文摘Chua TS Fock KM Ng TM 2005World J2005,1047,:1
8Evaluation of the impeller shroud performance of an axial flow ventricular assist device using computational fluid dynamics 显示文摘Su Boyang Chua LP Lim TM 2010Artif Organs2010,34,9:1
9Numerical study of bio-centrifugal blood pump with straight impeller blade profiles显示文摘Song GL Chua LP Lim TM 2009Artificial Organs2009,34,2:1
10Ventilator-associated pneumonia:gearing towards shorter-course therapy显示文摘Chua Tde J File TM Jr 0,,02:1
11Helicobacter pylori eradication varsus prokinetics in the treatment of functional dyspepsia: a randomized, double-blind study显示文摘Ang TL Fock KM Teo EK Chan YH Ng TM Chua TS 2006J Gastroenterol2006,41,7:1
12Circulating tumour cells and the epithelial mesenchymal transition in colorec- tal cancer显示文摘Lim SH Becker TM Chua W 2014J Clin Pathol2014,67,10:1
13Numerical study of a complete anastomosis model for the coronary artery bypass 显示文摘Chua LP Zhang JM Zhou TM 2005Heat and Mass Tranf2005,32,3:1
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