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| 1 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 2 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 3 | Modulation of protein release from chitosan-alginate microcapsules using the pHsensitive polymer hydroxypropyl methyl cellulose acetate succinate 显示文摘 | Okhamafe AO Amsden B Chu W | 1996 | J Microencapsul1996，13，5： | 2 |
| 4 | Faraday current sensor that uses a triangular-shaped bulk-optic sensing element 显示文摘 | CHU B C B NING Y N JACKSON D A | 1992 | Opt Lett1992，17，16： | 2 |
| 5 | Observations on changes in ultrasonically treated waste-activated sludge显示文摘 | Chu C P Chang B V Liao G S | 2001 | Wat Res2001，35，4： | 1 |
| 6 | Paraoxonase-1 defciency in mice predisposes to vascular inflammation,oxidative stress,and thrombogenicity in the absence of hyperlipidemia显示文摘 | Ng DS Chu T Esposito B | 2008 | Cardiovasc Pathol2008，17，4： | 1 |
| 7 | Photodegradation of 2,2',5,5'-tetrachlorobiphenyl in hexane 显示文摘 | Miao X S Chu S G Xu X B | 1996 | Bull Environ Contam Toxicol1996，72，4： | 1 |
| 8 | Downregulation and abromal expression of E-cadherin and β-catenin in nasopharyngeal carcinoma:close association with advanced disease stage and lymph node metastasis显示文摘 | Zheng Z Pan J Chu B | 1999 | Hum Pathol1999，30，4： | 1 |
| 9 | Stick-slip-separation analysis and non-linear stiffness and damping characterization of friction contact shaving variable normal load 显示文摘 | Yang B D Chu M L Menq C H | 1998 | Journal of Sound and Vibration1998，210，4： | 1 |
| 10 | Anodic dissolution of spongy titanium in ethanol solution for preparation of nano-sized Tio2 powder显示文摘 | Zhou X F Chu D B Lin C J | 2002 | Electrochim Acta2002，47，： | 1 |
| 11 | Mercury stack emissions from U S electric power plants显示文摘 | Chu P Porcella D B | 1995 | Water Air and Soil Pollution1995，80，： | 1 |
| 12 | Assoeiation between carotidplaque characteristics and subsequent ischemic cerebrovascular events:a pro- spective assessment with MRI-initial results显示文摘 | Takaya N Yuan C Chu B | 2006 | Stroke2006，37，3： | 1 |
| 13 | Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-anal- ysis 显示文摘 | Chu S G Becker R C Berger P B | 2010 | J Thromb Haemost2010，8，1： | 1 |
| 14 | Functional electrospun nanofibrous scaffolds for biomedical applications显示文摘 | Liang D Hsiao BS Chu B | 2007 | Adv Drug Deliv Rev2007，59，14： | 1 |
| 15 | Superconductor and Magnet Levitation Devices 显示文摘 | Ma K B Postrekhin Y V Chu W K | 2003 | Review of Seientif-ie Instruments2003，74，12： | 1 |
| 16 | Sid- erophore uptake in bacteria and the battle for iron with the host; a bird's eye view 显示文摘 | Chu B C Garcia-Herrero A Johanson T H | 2010 | Biornetals2010，23，： | 1 |
| 17 | Biomechanical design of the Berkeley lower Extremity Exoskeleton (BLEEX) 显示文摘 | ZOSS A B KAZEROONI H CHU Andrew | 2006 | IEEE/ASME Trans on Mechatronics2006，11，2： | 1 |
| 18 | Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells 显示文摘 | Chu VT Weber T Wefers B | 2015 | Nat Biotechnol2015，33，5： | 1 |
| 19 | Electric- field control of local ferromagnetism using a magnetoelec- tric multiferroic 显示文摘 | Chu Y H Martin L W Holeomb M B | 2008 | Nature Materials2008，7，6： | 1 |
| 20 | Ass~iation between carotid pl- aque characteristics and subsequent ischemic cerebrovasc~ar events:A prospective assessment with MRI-im'tial ~ts显示文摘 | Takaya N Yuan C Chu B ~ al | 2006 | St- rake2006，37，： | 1 |
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