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		题名	作者	年代	出处	被引量
	1	Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy显示文摘AIM: To evaluate the implication of substitutions in the hepatitis C virus (HCV) non-structural 5A (NS5A) protein in the resistance of HCV during mono-interferon (IFN) or combined IFN-ribavirin (IFN-R) therapy. Although NS5A has been reported to interact with the HCV RNA- dependent RNA polymerase, NS5B, as well as with many cellular proteins, the function of NS5A in the life cycle of HCV remains unclear. METHODS: HCV quasispecies were studied by clon- ing and sequencing of sequential isolates from patients infected by HCV genotype 1b. Patients were treated by IFN-α2b for 3 mo followed by IFN-α2b alone or com- bined IFN-R therapy for 9 additional months. Patients were categorized intro two groups based on their re- sponse to the treatments: 7 with sustained virological re- sponse (SVR) (quasispecies = 150) and 3 non-respond- ers (NR) to IFN-R (quasispecies = 106). RESULTS: Prior to treatment, SVR patients displayed a lower complexity of quasispecies than NR patients. Most patients had a decrease in the complexity of quasispe- cies during therapy. Analysis of amino acids substitu- tions showed that the degree of the complexity of the interferon sensitivity-determining region (ISDR) and the V3 domain of NS5A protein was able to discriminate thetwo groups of patients. Moreover, SVR patients displayed more variability in the NS5A region than NR patients. CONCLUSION: These results suggest that detailed mo- lecular analysis of the NS5A region may be important for understanding its function in IFN response during HCV 1b infection.	Pascal Veillon Christopher Payan Hélène Le Guillou-Guillemette Catherine Gaudy Franoise Lunel	2007	World Journal of Gastroenterology2007，13，8：	9
	2	Intraductal papillary or mucinous tumors (IPMT) of the pancreas: Report of a case series and review of the literature显示文摘	Christophe Zamora JoseJosé Sahel Dora Garcia Cantu Laurent Heyries Jean Paul Bernard Christophe Bastid Marie José Payan Igor Sielezneff Luigi Familiari Bernard Sastre Marc Barthet	2001	The American Journal of Gastroenterology2001，，5：	1
	3	Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea: The IVANHOE study显示文摘	Arnaud Gagneur Emmanuel Nowak Thomas Lemaitre Jean-Francois Segura Nadège Delaperrière Lydie Abalea Elise Poulhazan Anne Jossens Lucie Auzanneau Adissa Tran Christopher Payan Nadine Jay Loic de Parscau Emmanuel Oger	2011	Vaccine2011，，21：	1

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