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| 1 | 肿瘤坏死因子及其受体在鼠失血性休克引起的急性肺损伤中的作用显示文摘目的 探讨失血性休克引起的急性肺损伤与肿瘤坏死因子 α(TNF α)在肺组织表达的相关性。方法 通过心腔穿刺对C5 7小鼠采取 30 %全血容量复制失血性休克模型。肺组织TNF α表达采用酶联免疫吸附法方法进行测定。肺组织中性粒细胞 (PMN)浸润采用数字荧光显微镜免疫荧光技术进行检测。肺微血管通透性 (肺水肿 )采用伊文氏蓝方法进行测定。结果 ( 1)虽然失血性休克仅引起肺组织TNF α水平轻度和短暂的升高 ,且肺组织中性粒细胞 (PMN)浸润时相上早于TNF α水平的升高。但在TNF基因剔除 (KO)小鼠 ,失血性休克引起的肺组织PMN浸润和肺损伤明显轻于C5 7野生型小鼠 ;( 2 )给予失血前TNFKO小鼠低水平的重组TNF α即可导致失血性休克引起肺组织PMN浸润和急性肺损伤 ;( 3)失血性休克引起的肺组织PMN浸润和急性肺损伤在p5 5TNF受体KO动物显著减轻 ,而在p75TNFKO动物则不产生影响。结论 肺组织低水平TNF α足以介导失血性休克引起的PMN浸润和急性肺损伤 ;p5 5TNF受体在失血性休克引起的肺部急性炎症反应中起主导作用。 | 宋勇 施毅 Alden H Harken Xianzhong Meng Christopher D Raeburn | 2003 | 中华医学杂志2003，83，8： | 12 |
| 2 | Obstructive sleep apnea syndrome and fatty liver: Association or causal link?显示文摘Obstructive sleep apnea (OSA) is a complex disorder that consists of upper airway obstruction, chronic intermittent hypoxia and sleep fragmentation. OSA is well known to be associated with hypoxia, insulin resistance and glucose intolerance, and these factors can occur in the presence or absence of obesity and metabolic syndrome. Although it is well established that insulin resistance, glucose intolerance and obesity occur frequently with non-alcoholic fatty liver disease (NAFLD), it is now becoming apparent that hypoxia might also be important in the development of NAFLD, and it is recognized that there is increased risk of NAFLD with OSA. This review discusses the association between OSA, NAFLD and cardiovascular disease, and describes the potential role of hypoxia in the development of NAFLD with OSA. | Mohamed H Ahmed Christopher D Byrne | 2010 | World Journal of Gastroenterology2010，16，34： | 7 |
| 3 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019，25，26： | 3 |
| 4 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 5 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 6 | Using simula- tion to inteIpret a discrete time survival model in a complex biological system: fertility and lameness in dairy cows显示文摘 | Christopher D H Jonathan N H Martin J G | 2014 | Plos 0ne2014，9，8： | 1 |
| 7 | Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer’s Disease显示文摘 | Masaaki Takahashi Sylvain Doré Christopher D Ferris Taisuke Tomita Akira Sawa Herman Wolosker David R Borchelt Takeshi Iwatsubo Seong-Hun Kim Gopal Thinakaran Sangram S Sisodia Solomon H Snyder | 2000 | Neuron2000，，2： | 1 |
| 8 | Analysis of the anticoccidial drug,halofuginone,in chicken feed using gas-liquid chromatography and high-performance liquid chromatography显示文摘 | Anderson A Christopher D H Woodhouse R N | 1979 | Journal of Chromatography1979，168，： | 1 |
| 9 | 3-D mapping of regional soil hydraulic characteristics through establishment of pedo-transter functions显示文摘 | Mei D Hui H Christoph N | 2012 | Disaster Advances2012，5，4： | 1 |
| 10 | Connell integrate the effects of climate change across entire systems that predicting ecosystem shifts requires new approaches显示文摘 | Bayden D R Christopher D G H Thomas W | | 0，，10： | 1 |
| 11 | 查看详情显示文摘 | Christopher A S Rasmus H Arfa R.M Warwick B D Gillian M S Royston G Alan J D | | 0，，01： | 1 |
| 12 | Membrane fouling reduction by backpulsing and surface modification显示文摘 | Ma H M Christopher N B Robert H D | 2000 | Journal of Membr Sci2000，173，： | 1 |
| 13 | Correlation of enhanced thrombospondin - 1 expression, TGF - β signalling and proteinuria in human type - 2 diabetic nephropathy 显示文摘 | Bemd H Christoph D Birgit H | 2008 | Nephrol Dial Transplant2008，23，12： | 1 |
| 14 | A methodology for manufacturing process signature analysis显示文摘 | Eppinger Steven D Huber Christopher D Pham Van H | 1995 | Journal of Manufacturing Systems1995，14，1： | 1 |
| 15 | Chemi cal recycling of carbon fibre composites using alcohols under subcritical and supercritical conditions显示文摘 | RAUL P H JUAN G S CHRISTOPHER D | 2008 | Journal of Super- critical Fluids2008，46，： | 1 |
| 16 | Microencapsulation of Tamoxifen : Application to Cotton Fabric显示文摘 | MAZ H YU D G CHRISTOPHER J | 2009 | Colloids Surf B Biointerfaces2009，69，1： | 1 |
| 17 | Synthesis of Highly Ordered,Three-Dimensional,Macroporous Structures of Amorphous or Crystalline Inorganic Oxides,Phosphates,and Hybrid Composites显示文摘 | Brian T H Christopher F B Thang D | 2004 | Chem Mater2004，16，11： | 1 |
| 18 | Multi scale modeling of grouted sand behavior显示文摘 | Pierre Yves H Ching S C Christophe D | | 0，，： | 1 |
| 19 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 20 | Loss of INI 1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma显示文摘 | Jason H L Paola D C Christopher F D M | 2009 | Am J Surg Pathol2009，33，4： | 1 |
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