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| 1 | 【原创论文】德国东西部睾丸癌后发生第二原发癌的风险关注对侧睾丸癌显示文摘上世纪70年代起以顺铂为基础的化疗使睾丸癌的存活率显著提高。然而,化疗和放疗具有潜在的致癌性。本研究的目的是评估德国睾丸癌存活者患第二原发癌(包括原发组织学类型精原细胞瘤和非精原细胞瘤)的风险。我们确认了德国东部地区(1961-1989年和1996-2008年)癌症登记的16990例睾丸癌和德国西部地区萨尔州(1970.2008年)癌症登记的1401例睾丸癌。我们用标准化发病率(SIRs)和95%N信区间(95%CI)估计第二原发癌的风险。我们将估计的年标准化发病率绘制成图以显示趋势。德国东部1961.1989年观察到301例第二原发癌(SIR:1.9;95%CI:1.7-2.1),1996—2008年观察到159例第二原发癌(SIR:1.7:95%CI:1.4~2.0)。两地癌症登记的对侧睾丸癌增加(SIR:萨尔6.0,德国东部13.9)。与其它地区相比,德国东部精原细胞瘤的SIR增加更为显著。数据分析显示对侧睾丸癌的SIR有稳定的趋势。大多数其它癌症(包括组织学特异性肿瘤)的SIRs的估计精度低,可能与样本量较小有关。睾丸癌患者患第二原发癌尤其是对侧睾丸癌的风险增加,因此应进行严密随访。 | Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 2 | Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients显示文摘AIM: To study whether the glucocorticoid receptor (GR/ NR3C1) gene haplotypes influence the steroid therapy outcome in inflammatory bowel disease (IBD). METHODS: We sequenced all coding exons and flanking intronic sequences of the NR3C1 gene in 181 IBD patients, determined the single nucleotide polymorphisms, and predicted the NR3C1 haplotypes. Furthermore, we investigated whether certain NR3C1 haplotypes are significantly associated with steroid therapy outcomes. RESULTS: We detected 13 NR3C1 variants, which led to the formation of 17 different haplotypes with a certainty of > 95% in 173 individuals. The three most commonly occurring haplotypes were included in the association analysis of the influence of haplotype on steroid therapy outcome or IBD activity. None of the NR3C1 haplotypes showed statistically signifi cant association with glucocorticoid therapy success. CONCLUSION: NR3C1 haplotypes are not related to steroid therapy outcome. | Jessica Mwinyi Christa Wenger Jyrki J Eloranta Gerd A Kullak-Ublick | 2010 | World Journal of Gastroenterology2010，16，31： | 2 |
| 3 | LRP and senile plaques in Alzheimer's disease:colocalization with apolipoprotein E and with activated astrocytes显示文摘 | Katrin A Ayae K Christa MW | 2002 | Molecular Brain Research2002，104，： | 1 |
| 4 | Zinc during and in convalescence from diarrhea has no DemoNs-trAble effect on subsequent morbidity and anthropometric status among infants 《6 mo of age显示文摘 | Christa L Fischer Walker Zulfiqar A Bhutta Nita Bhandari | 2007 | American Journal of Clinical Nutrition2007，85，3： | 1 |
| 5 | The effect of ultraviolet radiation on the vertical distribution and mor- tality of estuarine zooplankton显示文摘 | Christa L S Stephen M B and Sean R A | 2000 | J Plankton Res2000，22，12： | 1 |
| 6 | Occurrence and sorption behavior of sulfonamides,macrolides,and trimethoprim in activated sludge treatment显示文摘 | Gobel A Thomsen A Christa S | 2005 | Environmental Science and Technology2005，39，： | 1 |
| 7 | Using remotely-sensed estimates of soil moisture to infer soil texture and hydraulic properties across a semi-arid watershed 显示文摘 | JOSEPH A SANTANELLO J CHRISTA D | 2007 | Remote Sensing of Environment2007，110，1： | 1 |
| 8 | , Occurrence and Sorption Behavior of Sulfonamides, Macrolides, and Trimethoprim in Activated Sludge Treatment 显示文摘 | Gobel A Thomsen A Christa S | 2005 | Environmental Science and Technology2005，39，： | 1 |
| 9 | The effect of ultraviolet radiation on the vertical distribution and mortality of estuarine zooplankton显示文摘 | Christa L S Stephen M B Sean R A | 2000 | J Plankton Res2000，22，12： | 1 |
| 10 | Enhanced expression of 14-3-3 protein in reactive astrocytes in Creutzfeldt-Jakob disease brains显示文摘 | Yasuhiro K Ichiro A Christa J | 2004 | Acta Neurophthol2004，108，： | 1 |
| 11 | Rapid light curves: a new fluorescence method to assess the state of the photosynthetic apparatus 显示文摘 | CHRISTA C WHITE A J | 1999 | Pho tosynth Res1999，59，： | 1 |
| 12 | Occurrence and sorption behavior of sulfonamides, macrolides and trime- thoprim in activated sludge treatment显示文摘 | Gobel A Thomsen A Christa S | 2005 | Environmental Sci-ence and Technology2005，39，： | 1 |
| 13 | Estimation of the number of infectious measles viruses in live virus vaccines using quantitative real-time PCR显示文摘 | Johanna A C Schalk Christa van den Elzen | 2004 | J Virol Methods2004，117，2： | 1 |
| 14 | Occurrence and sorption behavior of sulfonamides,macrolides,and trimethoprim in activated sludge treatment显示文摘 | Gobel A Thomsen A Christa S | 2005 | Environmental Science and Technology2005，39，： | 1 |
| 15 | Effects of mechanical factors on the fracture healing process显示文摘 | Heigele Christa A | 1998 | Clini Orthopaed1998，355，： | 1 |
| 16 | Individual recognition and memory in lobster dominance显示文摘 | CHRISTA K JELLE A | 1998 | Animal behaviour1998，56，6： | 1 |
| 17 | Metabolic footprint of diabetes:a multiplatform metabolomics study in an epidemiological setting显示文摘 | KARSTEN SUHRE CHRISTA MEISINGER D(O)RING A | 2010 | PLoS One2010，，11： | 1 |
| 18 | Rapid light curves: a new fluorescence method to assess the state of the photosynthetic apparatus 显示文摘 | WHITE A J CHRISTA C | 1999 | Photosynthesis Research1999，59，： | 1 |
| 19 | A new technique of continuous interscalene nerve block 显示文摘 | Borezaart A P Joe F Christa D | 1999 | Can J Anesth1999，46，： | 1 |
| 20 | Bank Liquidity Crea- tion显示文摘 | Berger A N Christa H S B | 2009 | Review of Financial Studies2009，22，9： | 1 |
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