|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetic epidemiology of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disorder characterized by presence of abdominal pain or discomfort associated with altered bowel habits. It has three main subtypes- constipation predominant IBS(C-IBS),diarrhea predominant IBS(D-IBS) and IBS with mixed featuresof both diarrhea as well as constipation(M-IBS). Its pathophysiology and underlying mechanisms remain elusive. It is traditionally believed that IBS is a result of multiple factors including hypersensitivity of the bowel,altered bowel motility,inflammation and stress. Initial studies have shown familial aggregation of IBS suggesting shared genetic or environmental factors. Twin studies of IBS from different parts of world have shown higher concordance rates among monozygotic twins than dizygotic twins,and thus suggesting a genetic component to this disorder. Multiple studies have tried to link single-nucleotide polymorphisms(SNPs) to IBS but there is little evidence that these SNPs are functional. Various molecules have been studied and investigated by the researchers. Serotonin,a known neurotransmitter and a local hormone in the enteric nervous system,has been most extensively explored. At this time,the underlying gene pathways,genes and functional variants linked with IBS remain unknown and the promise of genetically-determined risk prediction and personalize medicine remain unfulfilled. However,molecular biological technologies continue to evolve rapidly and genetic investigations offer much promise in the intervention,treatment and prevention of IBS. | Jasbir Makker Sridhar Chilimuri Jonathan N Bella | 2015 | World Journal of Gastroenterology2015，21，40： | 20 |
| 2 | Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases:A prospective cohort study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and type-2 diabetes mellitus(T2DM)have an intricate bidirectional relationship.Individuals with T2DM,not only have a higher prevalence of non-alcoholic steatosis,but also carry a higher risk of progression to nonalcoholic steatohepatitis.Experts still differ in their recommendations of screening for NAFLD among patients with T2DM.AIM To study the prevalence of NAFLD and advanced fibrosis among our patient population with T2DM.METHODS During the study period(November 2018 to January 2020),59 adult patients with T2DM and 26 non-diabetic control group individuals were recruited prospectively.Patients with known significant liver disease and alcohol use were excluded.Demographic data and lab parameters were recorded.Liver elastography was performed in all patients.RESULTS In the study group comprised of patients with T2DM and normal alanine aminotransferase levels(mean 17.8±7 U/L),81%had hepatic steatosis as diagnosed by elastography.Advanced hepatic fibrosis(stage F3 or F4)was present in 12%of patients with T2DM as compared to none in the control group.Patients with T2DM also had higher number of individuals with grade 3 steatosis[45.8%vs 11.5%,(P<0.00001)and metabolic syndrome(84.7%vs 11.5%,P<0.00001)].CONCLUSION A significant number of patients with T2DM,despite having normal transaminase levels,have NAFLD,grade 3 steatosis and advanced hepatic fibrosis as measured by liver elastography. | Jasbir Makker Hassan Tariq Kishore Kumar Madhavi Ravi Danial Haris Shaikh Vivien Leung Umar Hayat Muhammad T Hassan Harish Patel Suresh Nayudu Sridhar Chilimuri | 2021 | World Journal of Gastroenterology2021，27，6： | 2 |
| 3 | Vitamin D deficiency is associated with mortality in the medical intensive care unit显示文摘 | Venkatram S Chilimuri S Adrish M | 2011 | Crit Care2011，15，6： | 1 |
| 4 | Vitamin D deficiency is associated with mortality in the medical intensive care unit显示文摘 | Venkatram S Chilimuri S Adrish M | 2011 | Crit Care2011，15，6： | 1 |
| 5 | Significance of Bowel Wall Thickening on Computed Tomography Scan: Higher Risk of Pathology Among African Americans Compared to Hispanics显示文摘 | Patel Pikeshkumar Widjaja David Blum Steve Glandt Mariela Akella Jagadish Chilimuri Sridhar Balar Bhavna | 2009 | Journal of the National Medical Association2009，，4： | 1 |
| 6 | Genetic epidemiology of irrita- ble bowel syndrome 显示文摘 | Makker J Chilimuri S Bella J N | 2015 | World J Gastroenterol2015，21，11： | 1 |
| 7 | Vitamin D deficiency is associated with mortality in the medicalintensive care unit显示文摘 | VENKATRAM S CHILIMURI S ADRISH M | 2011 | Crit Care2011，15，6： | 1 |
| 8 | Vitamin D deficiency is associated with mortality in the medical intensive care unit显示文摘 | Venkatram S Chilimuri S Adrish M | 2011 | Crit Care2011，15，6： | 1 |
| 9 | Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality显示文摘BACKGROUND There is little evidence about the association of pre-existing hepatitis C infection(HCV)with outcomes in patients with coronavirus disease 2019(COVID-19).AIM To assess the prevalence of history of HCV among patients with COVID-19 and to study the relationship of in-hospital mortality in relation with other predictors of poor outcomes in the presence or absence of COVID-19 induced acute liver injury.METHODS In a retrospective single-center study design,1193 patients with COVID-19 infection were studied.Patients were then classified into those with and without a history of HCV,50(4.1%)and 1157(95.9%)respectively.RESULTS Multivariate cox-regression models showed that age,HCV,D-Dimer,and ferritin were the only predictors of in-hospital mortality.Acute liver injury and fibrosis score(Fib-4 score)were not different between both groups.Multivariate coxregression model for liver profile revealed that aspartate aminotransferase/alanine aminotransferase ratio,Fib-4 score,and HCV were predictors of inhospital mortality.After propensity score matching HCV was the only predictor of mortality in the multivariate cox-regression model.A model including HCV was found to add predictive value to clinical and laboratory parameters.CONCLUSION In patients with COVID-19,history of HCV infection leads to an accentuated severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virulence,irrespective of baseline comorbidities,admission laboratory variables,or COVID-19-induced liver injury,which may be related to extrahepatic effects of HCV leading to enhanced ACE-2/TMPRSS mechanisms of SARS-CoV-2 viral entry,baseline cytokine-mediated pro-inflammation,and endothelial dysfunction. | Diana Ronderos Alaa Mabrouk Salem Omar Hafsa Abbas Jasbir Makker Ahmed Baiomi Haozhe Sun Nikhitha Mantri Yongsun Choi Ked Fortuzi Dongmin Shin Harish Patel Sridhar Chilimuri | 2021 | World Journal of Clinical Cases2021，9，29： | 1 |
| 10 | Vitamin I) deficiency is associated with mortality in the medical intensive care unit显示文摘 | Venkatram S Chilimuri S Adrish M el al | 2011 | Crit Care2011，15，： | 1 |
| 11 | 北极狐的秘密花园显示文摘漫长而黑暗的北极冬季,天空和地面逐渐模糊,陷入了似乎没有尽头的极夜中。洞外寒风凛冽,气温下降到零下两位数,毛还没长齐的小北极狐会被轻易夺走体温。银装素裹的世界里,捕食者虎视眈眈,随时会对不经世事的冒失鬼痛下杀手。 | 高原长蛸 Anders Angerbjorn(图) Sridhar Chilimuri(图) Daniel(图) Vadim Balakin(图) | 2019 | 奇趣百科(动物故事)2019，0，12： | 0 |
| 12 | Cytomegalovirus related fatal duodenal diverticular bleeding: Case report and literature review显示文摘Involvement of gastrointestinal tract by cytomegalovirus(CMV) is common. CMV infections mainly run their course without any clinical signs in immunocompetent hosts. In contrast, CMV can cause severe infections with serious consequences in a immunocompromised state typically associated with organ transplants, highly immunosuppressive cancer chemotherapy, advanced HIV infection or treatment with corticosteroids. The incidence and severity of these manifestations of CMV is directly proportional with the degree of cellular immune dysfunction, i.e., CD8+ Cytotoxic T-cell response. Clinical manifestations of CMV can become apparent in different situations including reactivation of CMV from latency, primary infection in a seronegative host, or exposure of a seropositive host to a new strain of CMV. As the clinical signs of CMV in immunodeficient patients are usually sparse, physicians should be highly vigilant about CMV infection, a treatable condition that otherwise is associated with significant mortality. Here we report a rare case of severe gastrointestinal CMV infection with sustained immunodeficiency secondary to treatment with steroids manifesting as fatal duodenal diverticular bleeding. | Jasbir Makker Bharat Bajantri Sailaja Sakam Sridhar Chilimuri | 2016 | World Journal of Gastroenterology2016，22，31： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员