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| 1 | Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients显示文摘Objective: The purposes of this study were to identify risk factors for cervical lymph node metastasis and to examine the association between BRAF^(V600E) status and clinical features in papillary thyroid microcarcinoma(PTMC).Methods: A total of 1,587 patients with PTMC, treated in Tianjin Medical University Cancer Institute and Hospital from January2011 to March 2013, underwent retrospective analysis. We reviewed and analyzed factors including clinical results, pathology records, ultrasound results, and BRAF^(V600E) status.Results: Multivariate logistic regression analyses demonstrated that gender(male) [odds ratio(OR) = 1.845, P = 0.000], age(< 45 years)(OR = 1.606, P = 0.000), tumor size(> 6 mm)(OR = 2.137, P = 0.000), bilateralism(OR = 2.011, P = 0.000) and extrathyroidal extension(OR = 1.555, P = 0.001) served as independent predictors of central lymph node metastasis(CLNM).Moreover, CLNM(OR = 29.354, P = 0.000) served as an independent predictor of lateral lymph node metastasis(LLNM). Among patients with a solitary primary tumor, those with tumor location in the lower third of the thyroid lobe or the isthmus were more likely to experience CLNM(P < 0.05). Univariate analyses indicated that CLNM, LLNM, extrathyroidal extension, and multifocality were not significantly associated with BRAF^(V600E) mutation.Conclusions: The present study suggested that prophylactic neck dissection of the central compartment should be considered in patients with PTMC, particularly in men with tumor size greater than 6 mm, age less than 45 years, extrathyroidal extension, and tumor bilaterality. Among patients with PTMC, BRAF^(V600E) mutation is not significantly associated with prognostic factors. For a better understanding of surgical management of PTMC and the risk factors, we recommend multicenter research and long-term follow-up. | Xiangqian Zheng Chen Peng Ming Gao Jingtai Zhi Xiukun Hou Jingzhu Zhao Xi Wei Jiadong Chi Dapeng Li Biyun Qian | 2019 | Cancer Biology & Medicine2019，16，1： | 54 |
| 2 | Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus显示文摘BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion.Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis;however,this method is invasive and prone to clinical sampling error.In order to address these issues,we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.AIM To investigate serum N-glycan profiling related to HBV-induced liver fibrosis and verify multiparameter diagnostic models related to serum N-glycan changes.METHODS N-glycan profiles from the sera of 432 HBV-infected patients with liver fibrosis were analyzed.Significant changed N-glycan levels (peaks)(P <0.05) in differentfibrosis stages were selected in the modeling group,and multiparameter diagnostic models were established based on changed N-glycan levels by logistic regression analysis.The receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy of N-glycans models.These models were then compared with the aspartate aminotransferase to platelet ratio index (APRI),fibrosis index based on the four factors (FIB-4),glutamyltranspeptidase platelet albumin index (S index),GlycoCirrho-test,and GlycoFibro-test.Furthermore,we combined multiparameter diagnostic models with alanine aminotransferase (ALT) and platelet (PLT) tests and compared their diagnostic power.In addition,the diagnostic accuracy of N-glycan models was also verified in the validation group of patients.RESULTS Multiparameter diagnostic models constructed based on N-glycan peak 1,3,4and 8 could distinguish between different stages of liver fibrosis.The area under ROC curves (AUROCs) of Model A and Model B were 0.890 and 0.752,respectively differentiating fibrosis F0-F1 from F2-F4,and F0-F2 from F3-F4,and surpassing other serum panels.However,AUROC (0.747) in Model C used for the diagnosis of F4 from F0-F3 was lower than AUROC (0.795) in FIB-4.In combination with ALT and PLT,the multiparameter models showed better diagnostic power (AUROC=0.912,0.829,0.885,respectively) when compared with other models.In the validation group,the AUROCs of the three combined models (0.929,0.858,and 0.867,respectively) were still satisfactory.We also applied the combined models to distinguish adjacent fibrosis stages of 432patients (F0-F1/F2/F3/F4),and the AUROCs were 0.917,0.720 and 0.785.CONCLUSION Multiparameter models based on serum N-glycans are effective supplementary markers to distinguish between adjacent fibrosis stages of patients caused by HBV,especially in combination with ALT and PLT. | Xi Cao Qing-Hua Shang Xiao-Ling Chi Wei Zhang Huan-Ming Xiao Mi-Mi Sun Gang Chen Yong An Chun-Lei Lv Lin Wang Yue-Min Nan Cui-Ying Chen Zong-Nan Tan Xue-En Liu Hui Zhuang | 2020 | World Journal of Gastroenterology2020，26，10： | 12 |
| 3 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 4 | A spatial-explicit dynamic vegetation model that couples carbon,water,and nitrogen processes for arid and semiarid ecosystems显示文摘Arid and semiarid ecosystems,or dryland,are important to global biogeochemical cycles.Dryland's community structure and vegetation dynamics as well as biogeochemical cycles are sensitive to changes in climate and atmospheric composition.Vegetation dynamic models has been applied in global change studies,but the complex interactions among the carbon(C),water,and nitrogen(N) cycles have not been adequately addressed in the current models.In this study,a process-based vegetation dynamic model was developed to study the responses of dryland ecosystems to environmental changes,emphasizing on the interactions among the C,water,and N processes.To address the interactions between the C and water processes,it not only considers the effects of annual precipitation on vegetation distribution and soil moisture on organic matter(SOM) decomposition,but also explicitly models root competition for water and the water compensation processes.To address the interactions between C and N processes,it models the soil inorganic mater processes,such as N mineralization/immobilization,denitrification/nitrification,and N leaching,as well as the root competition for soil N.The model was parameterized for major plant functional types and evaluated against field observations. | Chi ZHANG ChaoFan LI Xi CHEN GePing LUO LongHui LI XiaoYu LI Yan YAN Hua SHAO | 2013 | Journal of Arid Land2013，5，1： | 8 |
| 5 | Relationship between settlements and topographical factors:An example from Sichuan Province,China显示文摘Terrain can influence the spatial distribution of settlements. Studies on the terrain characteristics of settlements can help to understand the effects of the environment on human activities. This paper provides a quantitative analysis of the relationship between settlements and topographical factors. A statistically significant sample of residential locations and ASTER GDEM V2 were used to investigate terrain traits and settlements distributions. We selected eight topographical factors and introduced a practical concept, distributive entropy, into assessing the aggregation extent of the settlements' spatial distribution. The study showed that topography varies within the study area, and distributive entropy indicates that settlements have distinctive distribution tendency in statistic approach. According to the results of this study, mountain inhabitants prefer to settle in valleys. Additionally, with distributive entropy, residential suitability was divided to three levels: suitable, normal, and unsuited. The results showed that suitable area is small in Sichuan Province, accounting for 8.2%~29.9%; however, unsuited area is large, accounting for 33%~63.3%. | XI Chang-bai QIAN Tian-lu CHI Yao CHEN Jie WANG Jie-chen | 2018 | Journal of Mountain Science2018，15，9： | 8 |
| 6 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 7 | Prophylaxis of hepatitis B recurrence in post-liver transplantation patients with lamivudine-resistant YMDD mutant显示文摘大多数经常使用了的背景为肝炎 B 的移植以后的复发的治疗病毒(HBV ) 感染是 lamivudine,但是这药由于 YMDD 与高抵抗率被联系变异。在初步的报告, adefovir dipivoxil (副词) 被显示了对 HBV 的 lamivudine 抵抗的紧张举办活动。然而,在在肝移植(副) 以后的 HBV 感染的治疗的临床的经验仍然不是完全清楚的。这研究被瞄准从2004年3月与在 LT.Methods 前变异的 YMDD 在病人评估副词正肝炎 B 免疫球蛋白( HBIG )的预防功效到2006年3月,有长期的肝炎 B 的 16 个病人把lamivudine抵抗的 YMDD 异种在肝移植以前检测了并且对接枝再感染作为预防在副以后与副词正另外的肌内的 HBIG 接受了治疗。为肝功能,浆液 HBsAg, anti-HBs (HBIG ) , HBeAg, anti-HBc, anti-HBe, HBV-DNA,和 creatinine 的测试是估计的肝前或肝以后的 transplantation.Results 肝以后的移植是的这些病人的中部的后续 19.4 个月。十五个病人幸存,一个病人死于 hepatocellular 癌(HCC ) 的复发。有重要差别(10.98% 对 2.26% , P0.05 ) 处于在有在有 HBV-DNA 的 106 copies/ml 和那些上的 HBV-DNA 的病人之间的 YMDD 变异的率不到 106 copies/ml。十五个病人(93.8%)在 4 个星期有无法发现的 HBV-DNA 并且 1 (6.3%)在在副以后的 6 个月,没有肝炎 B 复发被 HBsAg 的坚持的测试检测, HBeAg ,并且 HBV-DNA 和与副词联系的浆液 creatinine 水平的没有增加在任何与肌内的 HBIG 相结合的 patients.Conclusion 副词被观察能有效地在副以后与从 HBV 复发变异的移植前 YMDD 阻止病人。 | ZHANG Qi CAI Chang-jie LU Ming-qiang LI Xi JIANG Nan JIANG Hua XU Chi LI Hua WANG Gen-shu YI Shu-hong ZHANG Jian ZHANG Jun-feng YI Hui-min ZHANG Ying-cai CHEN Gui-hua | 2007 | Chinese Medical Journal2007，，16： | 5 |
| 8 | Rb Protein is Essential to the Senescence-Associated Heterochromatic Foci Formation Induced by HMGA2 in Primary WI38 Cells显示文摘细胞的老朽是提供一个障碍给肿瘤的转变的房间周期拘捕的一张不可逆的表格。Rb (Retinoblastoma ) 小径的正直为为衰老的状态的稳定性提供一个分子的基础的联系老朽的 heterochromatin foci (SAHF ) 的形成是必要的。令人惊讶地,尽管高活动性组 A2 蛋白质(HMGA2 ) 能支持 tumorigenesis 并且在肿瘤房间禁止 Rb 功能, HMGA2 的高级表示是足够的在主要房间导致 SAHF 形成。决定 Rb 蛋白质是否在导致 HMGA2 的 SAHF 形成是必要的因此变得重要。在这研究,我们由 HMGA2,典型衰老的标记在被看见的宫外的表示建立了细胞的老朽和 SAHF 汇编 WI38 房间模型,包括 p53, p21 和 p16 的著名 upregulation,并且提高了 SA -- 和 E2F 目标基因的 downregulation 染色的牛乳糖。我们然后证明 Rb 小径禁止者 E7 蛋白质能部分在 WI38 房间在 HMGA2 表示以后废除 SAHF 形成的能力,显示 Rb 是为导致 HMGA2 的 SAHF 形成的一个关键因素。然而, Rb 弄空完全没救 HMGA2 导致的房间生长拘捕,建议 Rb 不是为在 WI38 房间的导致 HMGA2 的老朽的一条独占的小径。 | Xi Shi Baoqing Tian Lingxia Liu Yanyan Gao Chi Ma Namusamba Mwichie Wenlong Ma Liping Han Baiqu Huang Jun Lu Yu Zhang | 2013 | Journal of Genetics and Genomics2013，40，8： | 4 |
| 9 | Transumbilical enterostomy for Hirschsprung’s disease with a two-stage laparoscopy-assisted pull-through procedure显示文摘BACKGROUND A one-stage laparoscopic operation has recently been considered a favorable option for the management of patients with Hirschsprung's disease(HD)due to its superior cosmetic results.One-stage transanal endorectal pull-through for the treatment of rectosigmoid HD has been widely used in newborns without complications.However,enterostomy is required in some HD cases for enterocolitis and dilated colon.Our transumbilical enterostomy(TUE)and twostage laparoscopy-assisted anorectoplasty were effective and achieved a similar cosmetic effect to one-stage laparoscopy on the abdominal wall in patients with anorectal malformation,but the effect in patients with HD is unclear.AIM To evaluate the safety,efficacy and cosmetic results of TUE in two-stage laparoscopy-assisted pull-through for HD.METHODS From June 2013 to June 2018,53 patients(40 boys,13 girls;mean age at enterostomy:5.5±2.2 mo)who underwent enterostomy and two-stage laparoscopy-assisted pull-through for HD with stoma closure were reviewed at our institution.Two enterostomy approaches were used:TUE in 24 patients,and conventional abdominal enterostomy(CAE)in 29 patients.Eleven patients with rectosigmoid HD had severe preoperative enterocolitis or a dilated colon.26 patients had long-segment HD,and 16 patients had total colonic aganglionosis(TCA).The patients with left-sided HD underwent the two-stage laparoscopic Soave procedure,and the patients with right-sided HD and TCA underwent the laparoscopic Duhamel procedure.Demographics,enterostomy operative time,complications and cosmetic results were respectively evaluated.RESULTS There were no differences between the groups with respect to gender,age at enterostomy,weight and clinical type(P>0.05).No conversion to open technique was required.Two patients experienced episodes of stomal mucosal prolapse in the TUE group and 1 patient in the CAE group(8.33%vs 3.45%,P>0.05).No parastomal hernia was observed in either of the two groups.Wound infection at the stoma was seen in 1 case in the TUE group,and 2 cases in the CAE group(4.17%vs 6.90%,P>0.05).No obstruction was noted in any of the patients in the TUE group,whereas obstruction was found in 1 patient in the CAE group.Enterocolitis was observed in 3 and 5 patients in the TUE and CAE group,respectively(12.50%vs 17.24%,P>0.05).There was no significant difference between the TUE group and CAE group in terms of the incidence of soiling and constipation(P>0.05).The cosmetic result using the scar score in the TUE group was better than that in the CAE group(6.83±0.96 vs 13.32±1.57,P<0.05).CONCLUSION TUE is a safe and feasible method for the treatment of HD,and the staged enterostomy and two-stage laparoscopy-assisted pull-through achieved a similar cosmetic effect to the one-stage laparoscopic procedure. | Pei-Pei Xu Xiao-Pan Chang Xi Zhang Shui-Qing Chi Guo-Qing Cao Shuai Li De-Hua Yang Xiang-Yang Li Shao-Tao Tang | 2019 | World Journal of Gastroenterology2019，25，46： | 3 |
| 10 | Enhanced optical Kerr nonlinearity of MoS2 on silicon waveguides显示文摘A quasi-two-dimensional layer of MoS2 was placed on top of a silicon optical waveguide to form a MoS2–silicon hybrid structure. Chirped pulse self-phase modulation measurements were carried out to determine the optica Kerr nonlinearity of the structure. The observed increase in the spectral broadening of the optical pulses in the MoS2–silicon waveguide compared with the silicon waveguides indicated that the third-order nonlinear effect in MoS2 is about 2 orders of magnitude larger than that in silicon. The measurements show that MoS2 has an effective optical Kerr coefficient of about 1.1 × 10-16m2∕W. This work reveals the potential application of MoS2 to enhance the nonlinearity of hybrid silicon optical devices. | Linghai Liu Ke Xu Xi Wan Jianbin Xu Chi Yan Wong Hon Ki Tsang | 2015 | Photonics Research2015，3，5： | 3 |
| 11 | De novo identification and quantification of single amino-acid variants in human brain显示文摘单个氨基酸的变体(SAV ) 的察觉通常取决于单个核苷酸的多型性(SNP ) 数据库。这里,我们描述发现在 proteome 的 SAV 铺平 SNP 数据的独立人士的一个新奇方法。用定序算法的集体基于 spectrometry 的 de novo,肽候选人被识别并且与理论蛋白质数据库到相比在配对策略下面产生 SAV,它被数据库研究到控制跟随假发现率。在人的大脑纸巾,我们能充满信心地识别知道并且有多样的起源的新奇蛋白质变体。与 DNA/RNA 定序结合了,我们证实 SAV 源于 DNA 变化,拼接的 RNA 选择,和未知 post-transcriptional 机制。而且,在人的大脑纸巾的定量分析揭示 SAV 的几织物特定的微分表情。这条途径提供新奇存取给蛋白质变体的高产量的察觉,它可以为临床的 biomarker 发现和机械学的研究提供潜力。 | Zhi-Duan Su Quan-Hu Sheng Qing-Run Li Hao Chi Xi Jiang ZhengYan Ning Fu Si-Min He Philipp Khaitovich Jia-Rui Wu Rong Zeng | 2014 | Journal of Molecular Cell Biology2014，8，5： | 2 |
| 12 | Solar cycle dependence of the seasonal variation of auroral hemispheric power显示文摘Although much has been done on the hemispheric asymmetry (or seasonal variations) of auroral hemispheric power (HP), the dependence of HP hemispheric asymmetry on solar cycle has not yet been studied. We have analyzed data during 1979-2010 and investigated the dependence of HP hemispheric asymmetry/seasonal variation for the whole solar cycle. Here we show that (1) the hemispheric asymmetry of HP is positively correlated to the value of solar F10.7 with some time delay; (2) it is closely related to the coupling function between the solar wind and magnetosphere; and (3) the winter hemisphere receives more auroral power than the summer hemisphere for Kp ~0 to 6. The statistic results can be partly understood in the framework of the ionospheric conductivity feedback model. The similarity and differences between our results and previous results are discussed in the paper. | ZHENG Ling FU SuiYan ZONG QuiGang PARKS George WANG Chi CHEN Xi | 2013 | Chinese Science Bulletin2013，58，4： | 2 |
| 13 | Probe vehicle population and sample size for arterial speed estimation显示文摘 | Ruey Long Cheu Chi Xi Der-Hong Lee | 2002 | Computer-Aided Civil and Infrastructure Engineering2002，17，： | 1 |
| 14 | Berberine ra- diosensitizes human nasopharyngeal carcinoma by suppress- ing hypoxia-inducible factor-lot expression 显示文摘 | ZHANG CHI YANG XI ZHANG QU | 2014 | Acta Oto- Laryngologica2014，134，2： | 1 |
| 15 | The Influence of orthopotic paraspinal muscle-pediculated bone flaps on posterior spinal fusion in a ca- nine model 显示文摘 | Xi C Li Y Chi Z | 2011 | Spine ( Phila Pa 1976 )2011，36，1： | 1 |
| 16 | An Investigation on Precipitation Behaviour of Cu-Rich Phase in Super304H Heat-Resistant Steel by Three Dimensional Atom Probe显示文摘 | Chi Cheng Yu Dong Jian Xin Liu Wen Qing Xie Xi Shan | 2010 | Materials Science Forum2010，，654： | 1 |
| 17 | Combustion and inorganic bromine emission of waste printed circuit boards in a high temperature furnace 显示文摘 | Ming jiang Ni Han xi Xiao Yong Chi | 2012 | Waste Management2012，32，3： | 1 |
| 18 | High energy and high brightness laser compton backscattering gamma-ray source at IHEP显示文摘Based on the LINAC of BEPCII, a high-polarized, high bightness, energy-tunable, monoenergetic laser compton backscattering (LCS)gamma-ray source is under construction at IHEP. The gamma-ray energy range is from 1 MeV to 111 MeV. It is a powerful and hopeful researchplatform to reveal the underlying physics of the nuclear, the basic particles and the vacuum or to check the exist basic physical models, quantumelectrodynamic (QED) theories. In the platform, a 1.064 mm Nd:YAG laser system and a 10.6 mm CO_(2) laser system are employed. All the triggersignals to the laser system and the electron control system are from the only reference clock at the very beginning of the LINAC to make sure thetemporal synchronization. Two optical transition radiation (OTR) targets and two charged-couple devices (CCD) are used to monitor and to alignthe electron beam and the laser beam. With the LCS gamma-ray source, it is proposed to experimentally check the gamma-ray calibrations, thephoton-nuclear physics, nuclear astrophysics and some basic QED phenomena. | Guang-Peng An Yun-Long Chi Yong-Le Dang Guang-Yong Fu Bing Guo Yong-Sheng Huang Chuang-Ye He Xiang-Cheng Kong Xiao-Fei Lan Jia-Cai Li Fu-Long Liu Jin-Shui Shi Xian-Jing Sun Yi Wang Jian-Li Wang Lin Wang Yuan-Yuan Wei Gang Wu Guang-Lei Xu Xiao-Feng Xi Guo-Jun Yang Chun-Lei Zhang Zhuo Zhang Zhi-Peng Zheng Xiao-Ding Zhang Shao-Ping Zhang | 2018 | Matter and Radiation at Extremes2018，3，4： | 1 |
| 19 | The influence of ortbotopic paraspinalmuscle- pediculated bone flaps on posterior spinal fusion in a canine model显示文摘 | Xi CY Li YJ- Chi ZY | 2011 | Spine2011，36，1： | 1 |
| 20 | Real-time 3D shape inspection system of automotive parts based on structured light pattern 显示文摘 | Xu Jing Xi Ning Zhang Chi | 2011 | Optics & Laser Technology2011，43，1： | 1 |
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