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| 1 | Visualizing DC morphology and T cell motility to characterize DC-T cell encounters in mouse lymph nodes under mTOR inhibition显示文摘Mammalian target of rapamycin(mTOR),a serine/threonine kinase orchestrating cellular metabolism,is a crucial immune system regulator.However,it remains unclear how mTOR regulates dendritic cell(DC) function in vivo,especially DC-T cell encounters,a critical step for initiating adaptive immune responses.We dynamically visualized DC-T contacts in mouse lymph node using confocal microscopy and established an encounter model to characterize the effect of mTOR inhibition on DC-T cell encounters using DC morphology.Quantitative data showed mTOR inhibition via rapamycin altered DC shape,with an increased form factor(30.17%) and decreased cellular surface area(20.36%) and perimeter(22.43%),which were associated with Cdc42 protein downregulation(52.71%).Additionally,DCs adopted a similar morphological change with Cdc42 inhibition via ZCL278 as that observed with mTOR inhibition.These morphologically altered DCs displayed low encounter rates with T cells.Time-lapse imaging data of T cell motility supported the simulated result of the encounter model,where antigen-specific T cells appeared to reduce arrest in the lymph nodes of rapamycin-pretreated mice relative to the untreated group.Therefore,mTOR inhibition altered DC morphology in vivo and decreased the DC-T cell encounter rate,as well as Cdc42 inhibition.By establishing an encounter model,our study provides an intuitive approach for the early prediction of DC function through morphological quantification of form factor and area. | Qiaoya Lin Zheng Liu Meijie Luo Hao Zheng Sha Qiao Chenlu Han Deqiang Deng Zhan Fan Yafang Lu Zhihong Zhang Qingming Luo | 2019 | Science China(Life Sciences)2019，62，9： | 2 |
| 2 | Spin-coating derived LSM-SDC films with uniform pore structure显示文摘 | Fei Ye Zhicheng Wang Wenjian Weng Kui Cheng Chenlu Song Piyi Du Ge Shen Gaorong Han | 2007 | Thin Solid Films2007，，16： | 1 |
| 3 | Environment and COVID-19 incidence: A critical review显示文摘The coronavirus disease 2019(COVID-19)pandemic is an unprecedented worldwide health crisis.Many previous research studies have found and investigated its links with one or some natural or human environmental factors.However,a review on the relationship between COVID-19 incidence and both the natural and human environment is still lacking.This review summarizes the inter-correlation between COVID-19 incidence and environmental factors.Based on keyword searching,we reviewed 100 relevant peer-reviewed articles and other research literature published since January 2020.This review is focused on three main findings.One,we found that individual environmental factors have impacts on COVID-19 incidence,but with spatial heterogeneity and uncertainty.Two,environmental factors exert interactive effects on COVID-19 incidence.In particular,the interactions of natural factors can affect COVID-19 transmission in micro-and macro-ways by impacting SARS-CoV-2 survival,as well as human mobility and behaviors.Three,the impact of COVID-19 incidence on the environment lies in the fact that COVID-19-induced lockdowns caused air quality improvement,wildlife shifts and socio-economic depression.The additional value of this review is that we recommend future research perspectives and adaptation strategies regarding the interactions of the environment and COVID-19.Future research should be extended to cover both the effects of the environment on the COVID-19 pandemic and COVID-19-induced impacts on the environment.Future adaptation strategies should focus on sustainable environmental and public policy responses. | Jiatong Han Jie Yin Xiaoxu Wu Danyang Wang Chenlu Li | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 4 | A review of complications of polyacrylamide hydrogel injection显示文摘Once a popular injectable filler,polyacrylamide hydrogel(PAAG)has been banned in China since 2006 due to its unclear safety and long-term complications.However,it is still being used worldwide because of its huge commercial profit,leading to emerging complications and an urgent need for standardized clinical management.This review aimed to assess the properties,safety,and complications of PAAG and treatment strategies for its removal. | Chenlu Xiong Youbai Chen Yujian Xu Weiqian Jiang Xiangye Yin Dongsheng Chen Xiaojing Gong Tian He Yang An Yan Han | 2023 | Chinese Journal Of Plastic and Reconstructive Surgery2023，5，2： | 0 |
| 5 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
| 6 | Three-dimensional structure of liver vessels and spatial distribution of hepatic immune cells显示文摘As the largest internal organ of the human body,the liver has an extremely complex vascularnetwork and multiple types of immune cells.It plays an important role in blood circulation,material metabolism,and immune response.Optical imaging is an effective tool for studying finevascular structure and immunocyte distribution of the liver.Here,we provide an overview of thestructure and composition of liver vessels,the threedimensional(3D)imaging of the liver,andthe spatial distribution and immune function of various cell components of the liver.Especially,we emphasize the 3D imaging methods for visualizing fine structure in the liver.Finally,wesummarize and prospect the development of 3D imaging of liver vesels and immune cells. | Mengli Xu Zheng Liu Xinlin Li Xinru Wang Xuenan Yuan Chenlu Han Zhihong Zhang | 2023 | Journal of Innovative Optical Health Sciences2023，16，3： | 0 |
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