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| 1 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 2 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 3 | A botanical medicine dragon’s blood exhibited clinical antithrombosis efficacy similar to low molecular weight heparin显示文摘Deep vein thrombosis(DVT)is a common complication following traumatic fracture with a 0.5%–1%annual incidence.Low molecular weight heparin(LMWH)is the most commonly used anticoagulation drug for DVT prevention,but treatment with LMWH is invasive.Our aim is to compare the antithrombotic effect of dragon’s blood,an oral botanical anticoagulant medicine approved by the Chinese FDA,with LMWH in patients undergoing hip fracture surgery and to explore the molecular mechanisms of anticoagulation treatment.Our study recruited patients and divided them into LMWH and dragon’s blood treatment group.Coagulation index tests,Doppler ultrasound and mRNA sequencing were performed before and after anticoagulation therapy.There was no significant difference in postoperative DVT incidence between the two groups(23.1%versus 15.4%,P=0.694).D-dimer(D-D)and fibrinogen degradation product(FDP)showed significant reductions in both groups after anticoagulation treatments.We identified SLC4A1,PROS1,PRKAR2B and seven other genes as being differentially expressed during anticoagulation therapy in both groups.Genes correlated with coagulation indexes were also identified.Dragon’s blood and LMWH showed similar effects on DVT and produced similar gene expression changes in patients undergoing hip fracture surgery,indicating that dragon’s blood is a more convenient antithrombosis medicine(oral)than LMWH(hypodermic injection). | Jiangbin Liang Song Mei Xiangyu Qiao Wei Pan Yan Zhao Shaohui Shi Yaling Zhai Haizhao Wen Guoping Wu Chengyu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 4 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47hxovbbcquk6qq6x50.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 5 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 6 | Habitat suitability of Scapharca subcrenata (Lischke) inthe shallow water of the Xiaoheishan Island显示文摘The habitat suitability index(HSI) model was used to identify potential sites for sustainable restoration of ark shell, Scapharca subcrenata(Lischke), in the shallow water of Xiaoheishan Island, using a geographic information system framework. The seven input variables of the HSI model were sediment composition, water temperature, salinity, dissolved oxygen, water depth, p H, and ammonia. A non-linear suitability function for each variable factor was used to transform the value into a normalized quality index ranging from 0(nonsuitability) to 1(best suitability). In present study, the analysis of habitat suitability was conducted for four seasons respectively. The majority of the study area has a high HSI value(>0.6) year round, which implies a strong suitability for restoration, with the optimal habitat located on the eastern side of the island.Correspondence analysis indicated that water temperature was the main factor causing seasonal variation,while sediment composition and water depth were the two major reasons for the differences in sites. The results of this work could provide support for restoration decision making through identification of potential sites for sustainable establishment of S. subcrenata. | ZHOU Jian SONG Jingjing BM Qianling LIU Chengyue ZHANG Zhipeng TANG Haitian | 2016 | Acta Oceanologica Sinica2016，35，12： | 2 |
| 7 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 8 | Seminar on Sino-German Economic Development显示文摘SeminaronSino-GermanEconomicDevelopmentBySongChengyuOnthebasisoflongtermcooperatin,theChineseAssociationforinternationalUnder... | By Song Chengyu | 1997 | International Understanding1997，，2： | 1 |
| 9 | Carbon Dots-in-Zeolite via In-Situ Solvent-Free Thermal Crystallization:Achieving High-Efficiency and Ultralong Afterglow Dual Emission显示文摘Organic afterglow materials are highly desirable for optoelectronic applications,but they usually suffer from complex preparation process,low quantum efficiency,and short lifetime due to the ultrafast deactivation of the highly active excited states involved.Here,we succeeded in achieving solventfree thermal syntheses of high-efficiency afterglow CDs@zeolite composite materials by simply grinding the solid raw materials of zeolite and precursor CDs at room temperature,followed by thermal crystallization.This method afforded maximum embedding of CDs into growing zeolite crystals,as well as strong host–guest interaction to surpass the nonradiative transition of CDs,thus producing composite materials with ultralong dual emission of thermally activated delayed fluorescence and room temperature phosphorescence with a record high lifetime of 1.7 and 2.1 s,respectively,and the quantum yield of 90.7%.Furthermore,in a preliminary experiment,we applied the composite materials in alternatingcurrent light-emitting diode supplementary lighting,which exhibited a promising potential in optoelectronic applications. | Hongyue Zhang Kaikai Liu Jiancong Liu Bolun Wang Chengyu Li Wei Song Jiyang Li Ling Huang Jihong Yu | 2020 | CCS Chemistry2020，2，3： | 1 |
| 10 | Oral administration of the herbal oligonucleotide XKC-sRNA-h3 prevents angiotensinⅡ-induced hypertension in mice显示文摘Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeutic agents for various diseases.In the present study,we aimed to demonstrate that a herbal small RNA(s RNA),XKC-sRNA-h3(B55710460,F221.I000082.B11),exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme(ACE)in mice.When compared with captopril,oral administration of the sphingosine(d18:1)-XKC-s RNA-h3 bencaosome more effectively prevented angiotensin II-induced hypertensive cardiac damage and alleviated kidney injury in mice.Such findings indicated that XKC-sRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension. | Kegong Tang Xiaona Wang Yu Zhao Xiaobei Li Zhenyu Jiang Song Mei Mingrui Chen Yiming Ma Xinyi Du Xiangyu Qiao Na Sun Jiaqi Liu Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 11 | Analysis of non-coding small RNA similarity/sharing between plant and animal genomes显示文摘Dear Editor,During the construction and analysis of the Bencao(herbal)small RNA(s RNA)Atlas,the fact that many s RNAs from the human genome are present in the Bencao(herbal)database attracted our attention(Cao et al.,2023).The Bencao Atlas contains millions of s RNAs from hundreds of plants used in traditional Chinese Medicines(TCMs). | Fengming Huang Xiangyu Qiao Song Mei Cong Zhang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 12 | Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72显示文摘Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics. | Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 13 | Comprehensive study of a versatile polyol synthesis approach for cathode materials for Li-ion batteries显示文摘This work reports a comprehensive study of a novel polyol method that can successfully synthesize layered LiNi0.4Mn0.4Co0.2O2,spinel LiNi0.5Mn1.5O4,and olivine LiCoPO4 cathode materials.When properly designed,polyol method offers many advantages such as low cost,ease of use,and proven scalability for industrial applications.Most importantly,the unique properties of polyol solvent allow for greater morphology control as shown by all the resulting materials exhibiting monodispersed nanoparticles morphology.This morphology contributes to improved lithium ion transport due to short diffusion lengths.Polyol-synthesized LiNi0.4Mn0.4Co0.2O2 delivers a reversible capacity of 101 and 82 mAh.g-1 using high current rate of 5C and 10C,respectively.It also displays surprisingly high surface structure stability after chargedischarge processes.Each step of the reaction was investigated to understand the underlying polyol synthesis mechanism.A combination of in situ and ex situ studies reveal the structural and chemical transformation of Ni-Co alloy nanocrystals overwrapped by a Mn-and Li-embedded organic matrix to a sedes of intermediate phases,and then eventually to the desired layered oxide phase with a homogeneous distribution of Ni,Co,and Mn.We envisage that this type of analysis will promote the development of optimized synthesis protocols by establishing links between experimental factors and important structural and chemical properties of the desired product.The insights can open a new direction of research to synthesize high-performance intercalation compounds by allowing unprecedented control of intermediate phases using experimental parameters. | Hyeseung Chung Antonin Grenier Ricky Huang Xuefeng Wang Zachary Lebens-Higgins Jean-Marie Doux Shawn Sallis Chengyu Song Peter Ercius Karena Chapman Louis F.J.Piper Hyung-Man Cho Minghao Zhang Ying Shirley Meng | 2019 | Nano Research2019，12，9： | 0 |
| 14 | Environmental Protection In Germany显示文摘EnvironmentalProtectionInGermanybySongChengyuInvitedbytheStuttgartBranchoftheGerman-SinoFriendshipAssociation,adelegationofth... | Song Chengyu | 1997 | International Understanding1997，，1： | 0 |
| 15 | Volume Changes of Some Superconductive Oxides in Sintering Process显示文摘The volume changes(ΔV)of YECO,BSCCO and Y-substituted BSCCO superconductors in sintering process were measured and investigated.A comparison of volume change between these oxides indicates that the volume change is related with structural change and crystallizing dynamics. | CHE Guangcan SONG Chengyu CHEN Xiaolong LI Hua XIONG Jiwu ZHAO Zhongxian | 1992 | Chinese Physics Letters1992，9，1： | 0 |
| 16 | Herbal small RNAs in patients with COVID-19 linked to reduced DEG expression显示文摘In China,more than 80%of patients with coronavirus disease 2019(COVID-19)received traditional Chinese medicine(TCM)as a treatment and their clinical efficacy have been reported.However,the underlying molecular mechanism remains unclear.Previous studies have identified herbal small RNAs(s RNAs)as novel functional components.In this study,a cohort of 22patients with COVID-19 treated with Toujie Quwen(TQ)granules was analyzed.We observed thousands of herbal small RNAs that entered the blood cells of patients after the consumption of TQ granules.In response to this treatment,the reduced differentially expressed genes(DEGs)were highly correlated with the predicted target genes of the most prevalent herbal s RNAs detected in the blood.Moreover,the predicted target genes of the top 30 s RNAs from each of the 245 TCMs in the Bencao s RNA Atlas overlapped with 337 upregulated DEGs in patients with mild COVID-19,and 33 TCMs,with more than 50%overlapping genes were identified as effective TCMs.These predicted target genes of top 30 s RNAs from Juhong,Gualoupi and Foshou were confirmed experimentally.Our results not only elucidated a novel molecular mechanism of TCM potential clinical efficacy for COVID-19 patients,but also provided 33 effective COVID-19 TCMs for prescription optimization. | Xiangyu Qiao Fengming Huang Xiaohu Shi Xingyu Deng Cong Zhang Song Mei Zhiqing Wang Congzhao Zhou Chengyu Jiang Xinghua Tan | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 17 | Automatic classification of rural building characteristics using deep learning methods on oblique photography显示文摘Rural building is important to the well-being of rural residents,leading to a significant need to carry out extensive surveys and retrofits of many rural buildings.On-site surveys by expert surveyors are currently the main approach,but this traditional method is often expensive and laborious,especially for large-scale survey tasks.Therefore,this study explores an alternative workflow based on deep learning(DL)methods to apply automatic classification of rural building characteristics.Taking four villages in Jizhou District of Tianjin,China as research samples,we tested selected convolutional neural network(CNN)architectures through the establishment of the training database containing 3258 labeled images,under the performance metrics of accuracy,recall and F1 score.The results showed that ResNet50 is the CNN architecture with the best performance,with the comprehensive consideration of overall metrics.Taking accuracy as the performance metric to test the generalization ability of ResNet50,the prediction results for seven building characteristic indicators from low to high are as follows:building function(0.827);building style(0.863);building quality(0.871);building age(0.880);building structure(0.891);abandoned or not(0.959);the number of storeys(0.995).Due to simplicity,accuracy and effectiveness,this workflow is transferable and cost-effective to investigate large-scale villages. | Chengyu Meng Yuwei Song Jiaqi Ji Ziyu Jia Zhengxu Zhou Peng Gao Sunxiangyu Liu | 2022 | Building Simulation2022，15，6： | 0 |
| 18 | Structural and microstructural transformations in Bi_2Sr_2Ca_(1-x)Y_xCu_2O_(8+y) system显示文摘SINCE the discovery of high-Tc superconductors, experiments have revealed that the phase diagrams of La2-xSrxCuO4 and YBa2Cu3O6+x resemble each other. The antiferromagnetic phase is commonly situated in the vicinity of the superconductive phase. In Bi-2212 sys- | SONG Chengyu, WEN Shulin and CHE Guangcan1. Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China 2. State Key Laboratory of Supercon-ductivity, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China | 1997 | Chinese Science Bulletin1997，42，3： | 0 |
| 19 | Symposium on Prospects for European Unification显示文摘SymposiumonProspectsforEuropeanUnificationSongChengyuSymposiumonProspectsforEuropeanUnification,jointlysponsoredbytheChineseA... | Song Chengyu | 1995 | International Understanding1995，，2： | 0 |
| 20 | Experience in Ruhr显示文摘ExperienceinRuhrSongChengyuRuhrGebiet,locatedinNordrheinWestfalenLandofGermany,isfamousforitsadvancedironandsteelandcoalindus... | Song Chengyu | 1995 | International Understanding1995，，4： | 0 |
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