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您的检索式：作者名="Chengyu Ku"
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| 1 | Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX显示文摘在 BCL-2 家庭蛋白质之间的相互作用决定房间的命运生活或死。他们怎么与对方一起交往调整 apoptosis,作为一个未解决的中央问题留下。到目前为止, antiapoptotic BCL-2 蛋白质被认为微弱地与 BAX 交往,但是这个相互作用的生理的意义是含糊的。此处,我们证明 recombinant BCL-2 和 BCL-w 与 3 包含域的肽从 BAX 导出的 BCL-2 相同(BH ) potently 交往,分别地展出 15 和 23 nM 的分离常数。为这个强壮的相互作用澄清基础,我们与跨越它的 BH3 领域的 BAX 肽决定了 BCL-2 的建筑群的三维的结构。它表明他们在正规 BH3 领域以外扩大并且包含了三 nonconserved 的相互作用控告了 BAX 的残余。新奇 BAX 变体,包含这三残余的丙氨酸替换,极大地为 BCL-2 和 BCL-w 损害了亲密关系,但是与野类型的 BAX 另外难区分。极其, BAX 变体的 apoptotic 活动不能被 BCL-2 和 BCL-w 制止,指观察紧密的相互作用为调整 BAX 激活是批评的。我们包括地也确定了与三 BCL-2 亚科蛋白质的有约束力的亲密关系。一起,数据表演由于为 BCL-2 , BCL-w 和 A1 的 BAX 的高亲密关系,并且为 BCL-XL , MCL-1 和 A1 的 BAK ,仅仅一个子集BH3仅仅蛋白质,通常包括的 BIM ,出价和美洲狮,能从 antiapoptotic BCL-2 蛋白质被期望到免费 BAX 或 BAK 得到 apoptosis 。 | Bonsu Ku Chengyu Liang Jae U Jung Byung-Ha Oh | 2011 | Cell Research2011，21，4： | 9 |
| 2 | A Novel Spacetime Collocation Meshless Method for Solving Two- Dimensional Backward Heat Conduction Problems显示文摘In this article,a meshless method using the spacetime collocation for solving the two-dimensional backward heat conduction problem(BHCP)is proposed.The spacetime collocation meshless method(SCMM)is to derive the general solutions as the basis functions for the two-dimensional transient heat equation using the separation of variables.Numerical solutions of the heat conduction problem are expressed as a series using the addition theorem.Because the basis functions are the general solutions of the governing equation,the boundary points may be collocated on the spacetime boundary of the domain.The proposed method is verified by conducting several heat conduction problems.We also carry out numerical applications to compare the SCMM with other meshless methods.The results show that the SCMM is accurate and efficient.Furthermore,it is found that the recovered boundary data on inaccessible boundary can be obtained with high accuracy even though the over specified data are provided only at a 1/6 portion of the spacetime boundary. | Chihyu Liu Chengyu Ku Jingen Xiao Weichung Yeih | 2019 | Computer Modeling in Engineering & Sciences2019，，1： | 1 |
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