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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | Minimum perimeter polygons of digitized silhouettes显示文摘 | Sklansky J Chazin R L Hansen B J | 1972 | IEEE Trans Computer1972，21，3： | 1 |
| 3 | Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells显示文摘 | Pietras R J Fendly B M Chazin V R | 1994 | Oncogene1994，9，7： | 1 |
| 4 | Structures of EF-hand Ca2+-binding proteins:diversity in the organization,packing and response to Ca2+binding显示文摘 | NELSON M R CHAZIN W J | 1998 | Biometals1998，11，4： | 1 |
| 5 | Minimum perimeter polygons of digitized silhouettes 显示文摘 | Sklansky J Chazin R L Hansen B J | 1972 | IEEE Trans Comput C1972，21，26： | 1 |
| 6 | Activation of UbcH5c Ub is the result of a shift in interdomain motions of the conjugate bound to U - box E3 ligase FAB显示文摘 | SOSS S E KLEV/T R E CHAZIN W J | 2013 | Biochemistry2013，52，17： | 1 |
| 7 | Regulation of S 100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity 显示文摘 | Nakatani Y Yamazaki M Chazin W J | 2005 | J Mediators Inflamm2005，2005，5： | 1 |
| 8 | The mode of action of centrin:binding of Ca2+ and a peptide fragment of Kar1p to the C-terminal domain显示文摘 | Hu H Sheehan J H and Chazin W J | 2004 | J Biol Chem2004，279，50： | 1 |
| 9 | Her-2/neu expression in node-negative breast cancer:direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease显示文摘 | Press M F Pike M C Chazin V R | 1993 | Cancer Res1993，53，20： | 1 |
| 10 | Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells显示文摘 | Van Meir EG Polverini PJ Chazin VR | 1994 | Nature Genet1994，8，： | 1 |
| 11 | Target selectivity in EF-hand calcium binding proteins显示文摘 | BHATTACHARYA S BUNICK C G CHAZIN W J | 2004 | Biochim Biophys Acta2004，1742，13： | 1 |
| 12 | Target selectivity in EF-band calcium binding proteins 显示文摘 | Bhattacharya S Bunick C G Chazin W J | 2004 | Biochim Biophys Acta2004，1742，1： | 1 |
| 13 | Effects of calcium binding on the side-chain methyl dynamics of calbindin D9k: a ^2H NMRrelaxationstudy显示文摘 | Johnson E Chazin W J Rance M | 2006 | J MolBiol2006，357，4： | 1 |
| 14 | Evaluation of the fracture resistance of reattached incisal fragments using different materials and techniques显示文摘 | Chazine M Sedda M Ounsi HF | 2011 | Dent Traumatol2011，27，1： | 1 |
| 15 | Structural Basis for Ligand Recognition and Activation of RAGE显示文摘 | Michael Koch Seth Chitayat Brian M. Dattilo Andre Schiefner Joachim Diez Walter J. Chazin Günter Fritz | 2010 | Structure2010，，10： | 1 |
| 16 | Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease 显示文摘 | PRESS M F PIKE M C CHAZIN V R | 1993 | Cancer Res1993，53，20： | 1 |
| 17 | Minimum perimeter polygonal of digitized silhouettes显示文摘 | Sklansky J Chazin R L Hansen B J | 1972 | IEEE Transactions on Computers1972，21，3： | 1 |
| 18 | Target selectivity in EF-hand calcium binding proteins 显示文摘 | Bhattacharya S Bunick C G Chazin W J | 2004 | Biochim Biophys Acta2004，1742，13： | 1 |
| 19 | Antibody to HER-2/nen receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells显示文摘 | Fendly BM Chazin VR | 1994 | Oneogene1994，9，7： | 1 |
| 20 | Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells显示文摘 | Pietras R J Fendly BM Chazin VR | 1994 | Oncogene1994，9，7： | 1 |
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