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| 1 | Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions显示文摘Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated disease.This stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor biology.Currently,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease control.This approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative measures.The optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain undefined.Given the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify patients.This classification will allow us to select the most appropriate therapeutic strategy on an individualized basis.In the future,the molecular or microRNA profiles will likely improve the treatment selection process.The objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and surgery.We also discuss areas of controversy and future directions. | Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro | 2019 | World Journal of Clinical Oncology2019，10，10： | 5 |
| 2 | Balloon angioplasty for native coarctation in children:immediate and medium-term results显示文摘 | Cerro D Aurora FR Benito F | 2005 | Rev Esp Cardiol2005，58，： | 1 |
| 3 | Interpersonal Aggression and the Type A Coronary-Prone Behavior Pattern:A Theoretical Distinction and Practical Implications显示文摘 | Strube M J Turner D W Cerro D Stevens J & Hinchey F | 1984 | Journal of Personality and Social Psychology1984，47，： | 1 |
| 4 | Chem Eng显示文摘 | Boeys C del Cerro M C Pyle D L | 1987 | (65): 218-2231987，，65： | 1 |
| 5 | Cerro Negro bitumen degradation by a consortium of marine benthic microorganisms 显示文摘 | POTTER T L CERRO D B | 2001 | Environmental Science & Technology2001，35，1： | 1 |
| 6 | Negro bitumen degradation by a consortium of marine benthic microorganisms 显示文摘 | Potter T L Cerro D B | 2001 | Environ Sci Technol2001，35，： | 1 |
| 7 | Neither intraocular grafts of retinal cell homogenates nor live non-retinal neurons produce behavioral recovery in rats with light - damaged retinas 显示文摘 | Del Cerro M DiLoreto D Lazar E | 1995 | Cell Transplant1995，，： | 1 |
| 8 | Percutaneous closure of atrial septal defect with the Amplatz device: initial result and mid -term follow -up显示文摘 | J Del Cerro Marin M Rubio Vidal D | 2001 | Rev Esp Cardiol2001，54，10： | 1 |
| 9 | Simultaneous detection of Aeromonas salrnonicida, Flavobacterium psychrophilum ,and Yersinia ruckeri, three major fish pathogens,by multiplex PCR显示文摘 | Cerro D A Marquez I Guijarro J A | 2002 | Applied and Environ- mental Microbiology2002，68，10： | 1 |
| 10 | Neither intraocular grafts of retinal cell homogenates nor live non-retinal neurons produce behavioral recovery in rats with light-damaged retinas 显示文摘 | DEL CERRO M DILORETO D COX C | 1995 | Cell Transplant1995，4，1： | 1 |
| 11 | Negro bitumen degradation by a consortium of marine benthic microorganisms显示文摘 | Potter T L Cerro D B | 2001 | Environ Sci Technol2001，35，： | 1 |
| 12 | Add-on therapy with subcutaneous treprostinil forrefractory pediatric pulmonary hypertension显示文摘 | Levy M Celermajer DS Bourges-Petit E Del Cerro MJ BajolleF Bonnet D | 2011 | J Pediatr2011，158，4： | 1 |
| 13 | Simultaneous detection ofAeromonas salmonicida, Flavobacterium psychrophilum, and Yersinia ruckeri, three major fish pathogens, by multiplex PCR显示文摘 | Cerro A D Marquez 1 Guijarro J A | 2002 | Appled and Environmental Microbiology2002，68，10： | 1 |
| 14 | Percutaneous cloure of atrial septal defect with the Amplatzer device: initial result and mid-term follow - up 显示文摘 | J Del Cerro Matin M Rubio Vidal D | 2001 | Rev Esp Candid2001，54，10： | 1 |
| 15 | DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation显示文摘BACKGROUND Oxidative damage of DNA and RNA has been associated with mortality of patients with different diseases.However,there is no published data on the potential use of DNA and RNA oxidative damage to predict the prognosis of patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).AIM To determine whether patients with increased DNA and RNA oxidative damage prior to LT for HCC have a poor LT prognosis.METHODS Patients with HCC who underwent LT were included in this observational and retrospective study.Serum levels of all three oxidized guanine species(OGS)were measured prior to LT since guanine is the nucleobase that forms DNA and RNA most prone to oxidation.LT mortality at 1 year was the end-point study.RESULTS Surviving patients(n=101)showed lower serum OGS levels(P=0.01)and lower age of the liver donor(P=0.03)than non-surviving patients(n=13).An association between serum OGS levels prior to LT and 1-year LT(odds ratio=2.079;95%confidence interval=1.356-3.189;P=0.001)was found in the logistic regression analysis.CONCLUSION The main new finding was that high serum OGS concentration prior to LT was associated with the mortality 1 year after LT in HCC patients. | Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio González María M Martín Alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera | 2022 | World Journal of Hepatology2022，14，6： | 0 |
| 16 | Patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations显示文摘BACKGROUND Fas ligand(FasL)is one ligand that activates extrinsic apoptosis pathway.High expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).No high blood concentrations of soluble FasL(sFasL)have been found in patients with acute LT rejection;however,the samples size of those studies was small.AIM To determine whether patients with hepatocellular carcinoma(HCC)that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample size.METHODS Patients underwent LT due to HCC were included in this retrospective study.Serum sFasL levels prior to LT were measured and one-year LT mortality was registered.RESULTS Non-surviving patients(n=14)showed higher serum sFasL levels[477(269-496)vs 85(44-382)pg/mL;P<0.001]than surviving patients(n=113).Serum sFasL levels(pg/mL)were associated with mortality(OR=1.006;95%CI=1.003-1.010;P=0.001)independently of age of LT donor in the logistic regression analysis.CONCLUSION We report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive. | Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio González María M Martín Alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera | 2023 | World Journal of Clinical Cases2023，11，8： | 0 |
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