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| 1 | Treatment of hepatocellular carcinoma in patients with portal vein tumor thrombosis: Beyond the known frontiers显示文摘Hepatocellular carcinoma is one of the most frequent malignant tumors worldwide:Portal vein tumor thrombosis(PVTT)occurs in about 35%-50%of patients and represents a strong negative prognostic factor,due to the increased risk of tumor spread into the bloodstream,leading to a high recurrence risk.For this reason,it is a contraindication to liver transplantation and in several prognostic scores sorafenib represents its standard of care,due to its antiangiogenetic action,although it can grant only a poor prolongation of life expectancy.Recent scientific evidences lead to consider PVTT as a complex anatomical and clinical condition,including a wide range of patients with different prognosis and new treatment possibilities according to the degree of portal system involvement,tumor biological aggressiveness,complications caused by portal hypertension,patient’s clinical features and tolerance to antineoplastic treatments.The median survival has been reported to range between 2.7 and 4 mo in absence of therapy,but it can vary from 5 mo to 5 years,thus depicting an extremely variable scenario.For this reason,it is extremely important to focus on the most adequate strategy to be applied to each group of PVTT patients. | Lucia Cerrito Brigida Eleonora Annicchiarico Roberto Iezzi Antonio Gasbarrini Maurizio Pompili Francesca Romana Ponziani | 2019 | World Journal of Gastroenterology2019，25，31： | 21 |
| 2 | Emerging actionable targets to treat therapyresistant colorectal cancers显示文摘In the last two decades major improvements have been reached in the early diagnosis of colorectal cancer(CRC)and,besides chemotherapy,an ampler choice of therapeutic approaches is now available,including targeted and immunotherapy.Despite that,CRC remains a“big killer”mainly due to the development of resistance to therapies,especially when the disease is diagnosed after it is already metastatic.At the same time,our knowledge of the mechanisms underlying resistance has been rapidly expanding which allows the development of novel therapeutic options in order to overcome it.As far as resistance to chemotherapy is concerned,several contributors have been identified such as:intake/efflux systems upregulation;alterations in the DNA damage response,due to defect in the DNA checkpoint and repair systems;dysregulation of the expression of apoptotic/anti-apoptotic members of the BCL2 family;overexpression of oncogenic kinases;the presence of cancer stem cells;and the composition of the tumoral microenvironment and that of the gut microbiota.Interestingly,several mechanisms are also involved in the resistance to targeted and/or immunotherapy.For example,overexpression and/or hyperactivation and/or amplification of oncogenic kinases can sustain resistance to targeted therapy whereas the composition of the gut microbiota,as well as that of the tumoral niche,and defects in DNA repair systems are crucial for determining the response to immunotherapy.In this review we will make an overview of the main resistance mechanisms identified so far and of the new therapeutic approaches to overcome it. | Emanuela Grassilli Maria Grazia Cerrito | 2022 | Cancer Drug Resistance2022，5，1： | 2 |
| 3 | Elastography as a predictor of liver cirrhosis complications after hepatitis C virus eradication in the era of direct-acting antivirals显示文摘Chronic inflammation due to hepatitis C virus(HCV)infection leads to liver fibrosis and rearrangement of liver tissue,which is responsible for the development of portal hypertension(PH)and hepatocellular carcinoma(HCC).The advent of direct-acting antiviral drugs has revolutionized the natural history of HCV infection,providing an overall eradication rate of over 90%.Despite a significant decrease after sustained virological response(SVR),the rate of HCC and liver-related complications is not completely eliminated in patients with advanced liver disease.Although the reasons are still unclear,cirrhosis itself has a residual risk for the development of HCC and other PH-related complications.Ultrasound elastography is a recently developed non-invasive technique for the assessment of liver fibrosis.Following the achievement of SVR,liver stiffness(LS)usually decreases,as a consequence of reduced inflammation and,possibly,fibrosis.Recent studies emphasized the application of LS assessment in the management of patients with SVR in order to define the risk for developing the complications of chronic liver disease(functional decompensation,gastrointestinal bleeding,HCC)and to optimize long-term prognostic outcomes in clinical practice. | Lucia Cerrito Maria Elena Ainora Alberto Nicoletti Matteo Garcovich Laura Riccardi Maurizio Pompili Antonio Gasbarrini Maria Assunta Zocco | 2021 | World Journal of Hepatology2021，13，11： | 1 |
| 4 | Sperm-mediated gene transfer显示文摘 | Lavitrano M Busnelli M Cerrito M G | 2005 | Reprod Fertil Dev2005，18，2： | 1 |
| 5 | Supraventricular tachycardia in infants: epidemiology and clinical management 显示文摘 | Calabr5 MP Cerrito M Luzza F | 2008 | Curr Pharm Des2008，14，8： | 1 |
| 6 | Supraventricular tachycardia in infants: Epidemiology and clinical management 显示文摘 | Calabrb MP Cerrito M Luzza F | 2008 | Curr Pharm Des2008，14，8： | 1 |
| 7 | Symmetry of ground reaction forces and muscle activity in asymptomatic subjects during walking, sit-to-stand, and stand-to-sit tasks 显示文摘 | Burnett DR Campbell-Kyureghyan NH Cerrito PB | 2011 | J Electromyogr Kinesiol2011，21，4： | 1 |
| 8 | Practical guidelines for optimal gamma probe detection of sentinel lymph nodes in breast cancer: Results of a multi-institutional study显示文摘 | Robert C.G. Martin Michael J. Edwards Sandra L. Wong Todd M. Tuttle David J. Carlson C.Matthew Brown R.Dirk Noyes Rebecca L. Glaser Donald J. Vennekotter Peter S. Turk Peter S. Tate Armando Sardi Patricia B. Cerrito Kelly M. McMasters for the University o | 2000 | Surgery2000，，： | 1 |
| 9 | Spermmediated gene transfer显示文摘 | Lavitrano M Busnelli M Cerrito M G | 2006 | Reprod Fertil Dev2006，18，： | 1 |
| 10 | EGF-induced activation of AKT resuhs roTOR-dependent p70S6 kinase phospholylation and inhibition of HC11 cell lactogenic differentiation 显示文摘 | Galbaugh T Cerrito MG Jose CC Cutler ML | 2006 | BMC Cell Biol2006，7，34： | 1 |
| 11 | Angiotensin-converting enzyme inhibition modulates high-glucose-induced extracellular matrix changes in mouse glomerular epithelial cells显示文摘 | Morano S Cipriani R Cerrito MG | 2003 | Nephron Exp Nephrol2003，95，1： | 1 |
| 12 | Resection of the metatarsal head for diabetic foot ulcers显示文摘 | WIEMAN T J MERCKE Y K CERRITO PB | 1998 | Am J Surg1998，176，5： | 1 |
| 13 | EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenie differentiation显示文摘 | CERRITO M G JOSE C C | 2006 | BMC Cell Biol2006，7，： | 1 |
| 14 | Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma显示文摘AIM To characterize the survival of cirrhotic patients with Barcelona Clinic Liver Cancer(BCLC) stage C hepatocellular carcinoma(HCC) and to ascertain the factors predicting the achievement of disease control(DC).METHODS The cirrhotic patients with BCLC stage C HCC evaluated by the Hepatocatt multidisciplinary group were subjected to the investigation. Demographic, clinical and tumor features, along with the best tumor response and overall survival were recorded. RESULTS One hundred and ten BCLC stage C patients were included in the analysis; the median overall survival was 13.4 mo(95%CI: 10.6-17.0). Only alphafetoprotein(AFP) serum level > 200 ng/m L and DC could independently predict survival but in a time dependent manner, the former was significantly associated with increased risk of mortality within the first 6 mo of follow-up(HR = 5.073, 95%CI: 2.159-11.916, P = 0.0002), whereas the latter showed a protective effect against death after one year(HR = 0.110, 95%CI: 0.038-0.314, P < 0.0001). Only patients showing microvascular invasion and/or extrahepatic spread recorded lower chances of achieving DC(OR = 0.263, 95%CI: 0.111-0.622, P = 0.002).CONCLUSION The BCLC stage C HCC includes a wide heterogeneous group of cirrhotic patients suitable for potentially curative treatments. The reverse and time dependent effect of AFP serum level and DC on patients' survival confers them as useful predictive tools for treatment management and clinical decisions. | Francesca Romana Ponziani Irene Spinelli Emanuele Rinninella Lucia Cerrito Antonio Saviano Alfonso Wolfango Avolio Michele Basso Luca Miele Laura Riccardi Maria Assunta Zocco Brigida Eleonora Annicchiarico Matteo Garcovich Marco Biolato Giuseppe Marrone Anna Maria De Gaetano Roberto Iezzi Felice Giuliante Fabio Maria Vecchio Salvatore Agnes Giovanni Addolorato Massimo Siciliano Gian Lodovico Rapaccini Antonio Grieco Antonio Gasbarrini Maurizio Pompili | 2017 | World Journal of Hepatology2017，9，36： | 1 |
| 15 | Supraventricular tachy?cardia in infants: epidemiology and clinical management显示文摘 | CALABRO MP CERRITO M LUZZA F | 2008 | Curr Pharm Des2008，14，8： | 1 |
| 16 | Chronic hypoxia and brain mtDNA deletions显示文摘 | Zullo S J Cerritos A Merril C R | 1999 | Arch Biochem Biophys1999，366，2： | 1 |
| 17 | Sperm Mediated Gene Transfer 显示文摘 | Lavitrano M Busnelli M Cerrito M G | 2006 | Reprod Fertil Dev2006，，18： | 1 |
| 18 | Sperm mediated gene transfer显示文摘 | Lavitrano M Busnelli M Cerrito MG | 2006 | Reprod Fertil Dev2006，18，12： | 1 |
| 19 | Heme oxygen- ase-1 inhibition prevents intimal hyperplasia enhancing ni- tric oxide-dependent apoptosis of vascular smooth muscle cells显示文摘 | Cerrito MG Scagliarini A Froio A | 2011 | Biol Pharm Bull2011，34，8： | 1 |
| 20 | Spermmediated gene transfer显示文摘 | Lavitrano M Busnelli M Cerrito M G | 2006 | Reprod Fertil Dev2006，18，12： | 1 |
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