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| 1 | Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease显示文摘Glucosamine and chondroitin sulfate are molecules involved in the formation of articular cartilage and are frequently used for symptom relief in patients with arthrosis.These molecules are well tolerated with scarce secondary effects.Very few cases of possible hepatotoxicity due to these substances have been described.The aim of this paper is to report the frequency of presumed glucosamine hepatotoxicity in patients with liver disease.A questionnaire was given to 151 consecutive patients with chronic liver disease of different etiology(mean age 59 years,56.9%women)attended in an outpatient clinic with the aim of evaluating the frequency of consumption of these drugs and determine whether their use coincided with a worsening in liver function test results.Twenty-three patients(15.2%)recognized having taken products containing glucosamine or chondroitin sulfate previously or at the time of the questionnaire.Review of the clinical records and liver function tests identified 2 patients presenting an elevation in aminotransferase values temporarily associated with glucosamine treatment;one of the cases simultaneously presented a skin rash attributed to the drug.Review of these two patients and the cases described in the literature suggest toxicity of glucosamine and chondroitin sulfate.The clinical spectrum is variable,and the mechanism of toxicity is not clear but may involve reactions of hypersensitivity.The consumption of products containing glucosamine and/or chondroitin sulfate is frequent among patients with chronic liver diseases and should be taken into account on the appearance of alterations in liver function tests not explained by the underlying disease. | Cristian Cerda Miguel Bruguera Albert Parés | 2013 | World Journal of Gastroenterology2013，19，32： | 2 |
| 2 | Stress and fold localization in thin e lastic membranes 显示文摘 | Pocivavsek L Dellsy R Kern A Johnson S Lin B Lee KY C Cerda E | 2008 | Science2008，320，： | 1 |
| 3 | Volatile composition of aged wine in used barrels of French oak and of American oak显示文摘 | CERDA'N T G RODRIGUEZ MOZAZ S ANCIN AZPILICUETA C | 2002 | Food Res hat2002，35，7： | 1 |
| 4 | Influence of oxygen radical injury on DNA methylation显示文摘 | Cerda S Weitzman S A | 1997 | Mutation Research-reviews In Mutation Research1997，386，： | 1 |
| 5 | Ursodeoxycholic acid inhibits Ras mutations,wild-type Ras activation,and cyclooxygenase-2 expression in colon cancer显示文摘 | Khare S Cerda S Wali RK | 2003 | Cancer Research2003，63，13： | 1 |
| 6 | Ursdeixycholic acid inhibits ras mutations,wild-type ras activation,and cyclooxygenase-2 expression in colon cancer显示文摘 | Khare S Cerda S Wali RK | 2003 | Cancer Res2003，63，13： | 1 |
| 7 | Spectrophotometric determinationof chloride in waters using a multisyringe flow injection system显示文摘 | MAYA F ESTELA J S CERDA V | 2008 | Talanta2008，74，5： | 1 |
| 8 | A distribution company energy acquisition market model with integration of distributed generation and load curtailment options显示文摘 | Palma-Behnke R Cerda J L A Vargas L S | 2005 | IEEE Transactions on Power Systems2005，20，4： | 1 |
| 9 | Evaluation of the endoscopic response to argon plasma coagulation in patients with chronic radiation proctopathy 显示文摘 | Latorre Sanchez M Sempere Garcfa-Argilelles J Barcelo Cerda S | 2008 | Rev Esp Enferm Dig2008，100，10： | 1 |
| 10 | Quantitative analysis of allele imbalance supports atypical ductal hyperplasia lesions as direct breast cancer precursors 显示文摘 | Larson P S Morenas A Cerda S R | 2006 | J Pathol2006，209，3： | 1 |
| 11 | Synthesis of CoFe2O4nanoparticles embedded in a silica matrix by the citrate precursor technique显示文摘 | GARCIA CERDA L A MONTEMAYOR S M | 2005 | J Magn Magn Mater2005，294，： | 1 |
| 12 | Ursodeoxycholic acid inhibits ras mutations,wild-type ras activation,and cyclooxygenase-2 expression in colon cancer显示文摘 | Khare S Cerda S Wali RK | 2003 | Cancer Res2003，63，13： | 1 |
| 13 | A study of partial replacement of fish meal with sunflower meal on growth, amino acid retention, and body composition of sharpsnout seabream, diplodus puntazzo ( Actinopterygii : perciformes : sparidae ) 显示文摘 | Merida S N Cerda M J Lloreens S M | 2011 | Acta Ichthyologica Et Piscatoria2011，41，1： | 1 |
| 14 | Orbital angular momentum of a high-order Bessel light beam: Special issue on atoms and angular momentum of light显示文摘 | VOLKE-SEPULVEDA K GARCES-CHoVEZ V CHOVEZ- CERDA S | 2002 | J Opt B: Quantum Semiclass2002，4，： | 1 |
| 15 | EGFR antagonist Iressa inhibits ERK activation, colonic crypt cell proliferation and ACF growth in mouse azoxymethane model of colon cancer显示文摘 | LITTLE N MUSTAFI R CERDA S | 2005 | Gastroenterology2005，128，： | 1 |
| 16 | Leukot- riene B4 and 8 - isoprostane in exhaled breath condensate of children with episodic and persistent asthma 显示文摘 | Caballero Balanza S Martorell Aragones A Cerda Mir JC | 2010 | J Invest Allergol Clin Immunol2010，20，3： | 1 |
| 17 | Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic ''metastases'' in vivo 显示文摘 | Broitman SA Wilkinson J 4th Cerda S | 1996 | Adv Exp Med Biol1996，401，： | 1 |
| 18 | Constitutive heterochromatin polymorphisms in human chromosomes identified by whole comparative genomic hybridization显示文摘 | Dávila-Rodríguez MI Cortés Gutiérrez EI Cerda Flores RM | 2011 | Eur J Histochem2011，55，3： | 1 |
| 19 | The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolized into bioavailable,but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microora of healthy humans显示文摘 | CERDA B ESPIN J C PARRA S | 2004 | Eur J Nutr2004，43，4： | 1 |
| 20 | A variational approach of nonlinear dissipative pulse propagation显示文摘 | Cerda S C Cavalcanti S B Hiekmann J M | 1998 | Eur Phys J D1998，1，3： | 1 |
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