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| 1 | New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review显示文摘In this paper review we describe benefits and disadvantages of the established methods of cartilage regeneration that seem to have a better long-term effectiveness.We illustrated the anatomical aspect of the knee joint cartilage, the current state of cartilage tissue engineering, through mesenchymal stem cells and biomaterials,and in conclusion we provide a short overview on the rehabilitation after articular cartilage repair procedures.Adult articular cartilage has low capacity to repair itself,and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, result-ing in significant pain and disability. Numerous efforts have been made to develop tissue-engineered grafts or patches to repair focal chondral and osteochondral defects, and to date several researchers aim to implement clinical application of cell-based therapies for cartilage repair. A literature review was conducted on PubM ed, Scopus and Google Scholar using appropriate keywords, examining the current literature on the wellknown tissue engineering methods for the treatment of knee osteoarthritis. | Giuseppe Musumeci Paola Castrogiovanni Rosalia Leonardi Francesca Maria Trovato Marta Anna Szychlinska Angelo Di Giunta Carla Loreto Sergio Castorina | 2014 | World Journal of Orthopedics2014，5，2： | 10 |
| 2 | Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer?显示文摘Aging is the most prominent risk factor contributing to the development of neurodegenerative disorders. In the United States, over 35 million of elderly people suffer from age-related diseases. Aging impairs the self-repair ability of neuronal cells, which undergo progressive deterioration.Once initiated, this process hampers the already limited regenerative power of the central nervous system, making the search for new therapeutic strategies particularly difficult in elderly affected patients. So far, mesenchymal stem cells have proven to be a viable option to ameliorate certain aspects of neurodegeneration, as they possess high proliferative rate and differentiate in vitro into multiple lineages. However, accumulating data have demonstrated that during longterm culture, mesenchymal stem cells undergo spontaneous transformation. Transformed mesenchymal stem cells show typical features of senescence, including the progressive shortening of telomers, which results in cell loss and, as a consequence, hampered regenerative potential. These evidences, in line with those observed in mesenchymal stem cells isolated from old donors, suggest that senescence may represent a limit to mesenchymal stem cells exploitation in therapy, prompting scholars to either find alternative sources of pluripotent cells or to arrest the age-related transformation. In the present review, we summarize findings from recent literature, and critically discuss some of the major hurdles encountered in the search of appropriate sources of mesenchymal stem cells, as well as benefits arising from their use in neurodegenerative diseases. Finally, we provide some insights that may aid in the development of strategies to arrest or, at least, delay the aging of mesenchymal stem cells to improve their therapeutic potential. | Alessandro Castorina Marta Anna Szychlinska Rubina Marzagalli Giuseppe Musumeci | 2015 | Neural Regeneration Research2015，10，6： | 8 |
| 3 | Dopamine: an immune transmitter显示文摘The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson’s disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson’s disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies. | Sarah Thomas Broome Krystal Louangaphay Kevin AKeay Gian Marco Leggio Giuseppe Musumeci Alessandro Castorina | 2020 | Neural Regeneration Research2020，15，12： | 5 |
| 4 | Critical endpoint and inverse magnetic catalysis for finite temperature and density quark matter in a magnetic background显示文摘 | M. Ruggieri L. Oliva P. Castorina R. Gatto V. Greco | 2014 | Physics Letters B2014，，： | 2 |
| 5 | Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus显示文摘 | Castorina A DAmico AG Scuderi S etal | 2013 | Neurosci2013，250，： | 1 |
| 6 | Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling,vimentin-positive cells and cell death显示文摘 | Loreto C Musumeci G Castorina A | | 0，，02： | 1 |
| 7 | High dynamic range imaging for digital still camera: an overview 显示文摘 | BATTIATO S CASTORINA A MANCUSO M M | 2003 | Journal of Electronic Imaging2003，12，3： | 1 |
| 8 | Effect of polymer co-ating on ammonium nitrate substrate显示文摘 | Castorina T C Smetana A F | 1974 | Journal of Applied Polymer Science1974，18，5： | 1 |
| 9 | Tackling dipeptidyl peptidase Ⅳ in neurological disorders显示文摘Dipeptidyl peptidase Ⅳ(DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1(GLP-1), pituitary adenylate cyclase-activating polypeptide(PACAP) and glucose-dependent insulinotropic peptide(GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inhibition of DPP-IV enzyme activity is considered as an attractive treatment option for diabetic patients. Nonetheless, increasing studies support the idea that DPP-IV might also be involved in the development of neurological disorders with a neuroinflammatory component, potentially through its non-incretin activities on immune cells. In this review article, we aim at highlighting recent literature describing the therapeutic value of DPP-IV inhibitors for the treatment of such neurological conditions. Finally, we will illustrate some of the promising results obtained using berberine, a plant extract with potent inhibitory activity on DPP-IV. | Ghaith Al-Badri Gian Marco Leggio Giuseppe Musumeci Rubina Marzagalli Filippo Drago Alessandro Castorina | 2018 | Neural Regeneration Research2018，13，1： | 1 |
| 10 | REE and Nd-isotope evidence for the origin of siderite from the Jebel Awam deposit (Central Morocco)显示文摘 | F. Castorina U. Masi | 2008 | Ore Geology Reviews2008，，3： | 1 |
| 11 | A High Sensitivity ConditioningCircuit for Capacitive Sensors Including Stray Effects Com-pensation and Dummy Sensors Approach 显示文摘 | BAGLIO S’CASTORINA S | 2004 | Instrumenta-tion and Measurement Technology Conference2004，，： | 1 |
| 12 | Crush syndrome显示文摘 | Scapellato S Maria S Castorina G | 2007 | Minerva Chir2007，62，4： | 1 |
| 13 | Exposures of children to organophosphate pesticides and their potential adverse health effects显示文摘 | ESKENAZI B BRADMAN A CASTORINA R | 1999 | Environmental Health Perspectives1999，107，3： | 1 |
| 14 | Carbaryl and naphthalene exposures among a pregnant latina popula- tion living in an agricultural area显示文摘 | Castorina R Harnly ME Eskenazi B | 2008 | Epidemiology2008，19，6： | 1 |
| 15 | Early effects of aluminum zhloride on beta-secretase mRNA expression in a neuronal model of β- amyloid toxicity显示文摘 | Castorina A Tiralongo A Giunta S | 2010 | Cell Biol Toxicol2010，26，： | 1 |
| 16 | Trisomy 4 leading to duplication of a mutated KIT allele in acute myeloid leukemia with mast cell involvement 显示文摘 | Beghini A Ripamonti CB Castorina P | 2000 | Cancer Genet Cytogenet2000，119，1： | 1 |
| 17 | Strontium isotope evidence for the origin of barite from four mineralisations of the Moroccan Meseta显示文摘 | F. Castorina E. Di Biasio U. Masi L. Tolomeo | 1999 | Journal of African Earth Sciences1999，，3： | 1 |
| 18 | Carbon-14 tracer studies of the nitrolysis of hexamethylenetetramine 显示文摘 | Castorina T C Holohan F S Graybush R J | 1960 | J Am Chem Soc1960，82，： | 1 |
| 19 | Nitrogen-15 tracer of the nitrolysis of hexamethylenetetramine 显示文摘 | Castorina T C Autera J R | 1965 | J Am Chem Soc1965，4，3： | 1 |
| 20 | Modeling and design of novel photo-thermo- mechanical microactuators显示文摘 | Baglio S Castorina S Fortuna L | 2002 | Sensors and Actutors A2002，101，： | 1 |
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