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| 1 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Transient receptor potential (TRPC) channels in human sperm:expression,cellular localization and involvement in the regulation of flagellar motility显示文摘 | Castellano LE Trevif(n)o CL Rodríguez D | | 0，，1： | 1 |
| 3 | Expression and differential cell distribution of low-threshold Ca^2 + channels in mammalian male germ ceils and sperm 显示文摘 | Trevino CL Felix R Castellano LE | 2004 | FEBS Lett2004，563，13： | 1 |
| 4 | Expression and differential cell distribution of low-threshold Ca2+ channels in mammalian male germ cells and sperm显示文摘 | Trevi(n)o CL Felix R Castellano LE | | 0，，1： | 1 |
| 5 | Transient receptor potential(TRPC) channels in human sperm: expression, cellular localization and involvement in the regulation of flagellar motility显示文摘 | Castellano LE Trevino CL Rodriguez D | 2003 | FEBS Lett2003，541，13： | 1 |
| 6 | Expression and differential cell distribution of low-threshold Ca^2+ channels in mammalian male germ cells and sperm显示文摘 | Trevino CL Felix R Castellano LE | 2004 | FEBS Lett2004，563，13： | 1 |
| 7 | CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells显示文摘 | Roni H.G. Wright Giancarlo Castellano Jaume Bonet Francois Le Dily Jofre Font-Mateu Cecilia Ballaré A. Silvina Nacht Daniel Soronellas Baldo Oliva Miguel Beato | 2012 | Genes & Development2012，，17： | 1 |
| 8 | Transient receptor potential (TRPC) channels in human sperm: expression, cellular localization and involvement in the regulation of flagellar motility 显示文摘 | Castellano LE Trevino CL Rodriguez D | 2003 | FEBS Lett2003，541，13： | 1 |
| 9 | Expression and differential cell distribution of low-threshold Ca2+ channels in mammalian male germ cells and sperm显示文摘 | Trevino CL Felix R Castellano LE | 2004 | FEBS2004，563，： | 1 |
| 10 | The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder显示文摘Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic approaches.To address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was launched.The REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from DIRECT.In this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD project.Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional lat-eralization.These well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven research.Following these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve sensitivity.Functional images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis boundaries.In addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are underway.Through these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized neuromodulation targets,while building an open repository for the scientific community. | Xiao Chen Bin Lu Hui-Xian Li Xue-Ying Li Yu-Wei Wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen Wei Chen Yu-Qi Cheng Shi-Xian Cui Zhao-Yu Deng Yi-Ru Fang Qi-Yong Gong Wen-Bin Guo Zheng-Jia-Yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-Fan Liao Yan-Song Liu Zhe-Ning Liu Jian-Ping Lu Qing-Hua Luo Hua-Qing Meng Dai-Hui Peng Jiang Qiu Yue-Di Shen Tian-Mei Si Yan-Qing Tang Chuan-Yue Wang Fei Wang Hua-Ning Wang Kai Wang Xiang Wang Ying Wang Zi-Han Wang Xiao-Ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu Hong Yang Jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang Wei Zhang Zhi-Jun Zhang Jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan | 2022 | Psychoradiology2022，2，1： | 1 |
| 11 | Expression and differential cell distribution of low-threshold Ca2+ channels in mammalian male germ cells ard sperm显示文摘 | Trevino CL Felix R Castellano LE | 2004 | FEBS Lett2004，563，13： | 1 |
| 12 | Expression and differential cell distribution of low-threshold Ca (2 +) channels in mammalian male germ cells and sperm显示文摘 | Trevino CL Felix R Castellano LE | 2004 | FEBS Lett2004，563，13： | 1 |
| 13 | Transient receptor potential (TRPC) channels in human sperm:expression,cellular localization and involvement in the regulation of flagellar motility显示文摘 | Castellano LE Trevino CL Rodriguez D | 2003 | FEBS Lett2003，541，13： | 1 |
| 14 | Expression and differential cell distribution of low-threshold Ca2+ channels in mammalian male germ cells and sperm显示文摘 | Trevino CL Felix R Castellano LE | 2004 | FEBS Lett2004，563，13： | 1 |
| 15 | Expression and differential cell distribution of low2threshold Ca2 + channels in mammalian male germ cells and sperm 显示文摘 | Trevino CL Felix R Castellano LE | 2004 | FEBS Left2004，563，123： | 1 |
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