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| 1 | Alcoholism: A systemic proinflammatory condition显示文摘Excessive ethanol consumption affects virtually any organ,both by indirect and direct mechanisms.Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of alcoholism.These cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria,which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut permeability.Reactive oxygen species(ROS)that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of ethanol.The effects of this increased cytokine secretion and ROS generation lie far beyond liver damage.In addition to the classic consequences of endotoxemia associated with liver cirrhosis that weredescribed several decades ago,important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain,bone,muscle,heart,lung,gonads,peripheral nerve,and pancreas.These effects are even seen in alcoholics without significant liver disease.Therefore,alcoholism can be viewed as an inflammatory condition,a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent disease.In this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver. | Emilio González-Reimers Francisco Santolaria-Fernández María Candelaria Martín-González Camino María Fernández-Rodríguez Geraldine Quintero-Platt | 2014 | World Journal of Gastroenterology2014，20，40： | 12 |
| 2 | Leptin signaling and cancer chemoresistance:Perspectives显示文摘Obesity is a major health problem and currently is endemic around the world. Obesity is a risk factor for several different types of cancer, significantly promoting cancer incidence, progression, poor prognosis and resistance to anti-cancer therapies. The study of this resistance is critical as development of chemoresistance is a serious drawback for the successful and effective drug-based treatments of cancer. There is increasing evidence that augmented adiposity can impact on chemotherapeutic treatment of cancer and the development of resistance to these treatments, particularly through one of its signature mediators, the adipokine leptin. Leptin is a pro-inflammatory, pro-angiogenic and pro-tumorigenic adipokine that has been implicated in many cancers promoting processes such as angiogenesis, metastasis, tumorigenesis and survival/resistance to apoptosis. Several possible mechanisms that could potentially be developed by cancer cells to elicit drug resistance have been suggested in the literature. Here, we summarize and discuss the current state of the literature on the role of obesity and leptin on chemoresistance, particularly as it relates to breast and pancreatic cancers. We focus on the role of leptin and its significance in possibly driving these proposed chemoresistance mechanisms, and examine its effects on cancer cell survival signals and expansion of the cancer stem cell sub-populations. | Pierre V Candelaria Antonio Rampoldi Adriana Harbuzariu Ruben R Gonzalez-Perez | 2017 | World Journal of Clinical Oncology2017，8，2： | 6 |
| 3 | Thrombin activation and liver inflammation in advanced hepatitis C virus infection显示文摘Hepatitis C virus(HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles. Increased thrombin formation may activate hepatic stellate cells and promote liver fibrosis. In addition, ischemic changes derived from vascular occlusion by microthrombi favor the so called parenchymal extinction, a process that promotes collapse of hepatocytes and the formation of gross fibrous tracts. These reasons may explain why advanced HCV infection may evolve more rapidly to end-stage liver disease than other forms of cirrhosis. | Emilio González-Reimers Geraldine Quintero-Platt Candelaria Martín-González Onán Pérez-Hernández Lucía Romero-Acevedo Francisco Santolaria-Fernández | 2016 | World Journal of Gastroenterology2016，22，18： | 5 |
| 4 | Bioreduction of nitrate in groundwater using a pilot-scale hydrogen-based membrane biofilm reactor显示文摘A long-term pilot-scale H_(2)-based membrane biofilm reactor(MBfR)was tested for removal of nitrate from actual groundwater.A key feature of this secondgeneration pilot MBfR is that it employed lower cost polyester hollow fibers and still achieved high loading rate.The steady-state maximum nitrate surface loading at which the effluent nitrate and nitrite concentrations were below the Maximum Contaminant Level(MCL)was at least 5.9 g·N·(m^(2)·d)^(–1),which corresponds to a maximum volumetric loading of at least 7.7 kg·N·(m^(3)·d)^(–1).The steady-state maximum nitrate surface area loading was higher than the highest nitrate surface loading reported in the firstgeneration MBfRs using composite fibers(2.6 g·N·(m^(2)·d)^(–1)).This work also evaluated the H_(2)-utilization efficiency in MBfR.The measured H_(2)supply rate was only slightly higher than the stoichiometric H_(2)-utilization rate.Thus,H_(2)utilization was controlled by diffusion and was close to 100%efficiency,as long as biofilm accumulated on the polyester-fiber surface and the fibers had no leaks. | Youneng TANG Michal ZIV-EL Chen ZHOU Jung Hun SHIN Chang Hoon AHN Kerry MEYER Daniel CANDELARIA David FRIESE Ryan OVERSTREET Rick SCOTT Bruce ERITTMANN | 2010 | Frontiers of Environmental Science & Engineering2010，4，3： | 4 |
| 5 | Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis显示文摘AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) infection.METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.CONCLUSION: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines. | emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández | 2016 | World Journal of Hepatology2016，8，1： | 2 |
| 6 | DC ring-bus microgrid fault protection and identification of fault location显示文摘 | Park J D Candelaria J Ma L | 2013 | IEEE Trans on Power Delivery2013，28，4： | 1 |
| 7 | Perception of self-selected running speed is influenced by the treadmill but not footwear显示文摘 | KONG P W CANDELARIA N G TOMAKA J | 2009 | Sports Biom2009，8，1： | 1 |
| 8 | Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors 显示文摘 | DUENAS-GONZALEZ A CANDELARIA M PEREZ- PLASCENCIA C | 2008 | Cancer Treat Rev2008，34，3： | 1 |
| 9 | Agent Based Simulation for Social Systems: From Modeling to Implementation显示文摘 | Sansores Candelaria Juan Pavon | 2006 | Current Topics in Artificial Intelligence2006，4177，： | 1 |
| 10 | Valproic acid as epigenetic cancer drug:preclinical,clinical and transcriptional effects on solid tumors显示文摘 | Duenas-Gonzalez A Candelaria M Perez-Plascencia C | 2008 | Cancer Treat Rev2008，34，3： | 1 |
| 11 | Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus 显示文摘 | Gustafson JE Candelaria PV Fisher SA | 1999 | Antimicrob Agents Chemother1999，43，： | 1 |
| 12 | Lack in efficacy for imatinib mesylate as second- line treatment of recurrent or metastatic cervical cancer expressing platelet-derived growth factor receptor alpha显示文摘 | Candelaria M Arias-Bonfill D Chvez-Blanco A | 2009 | Int J Gynecol Cancer2009，19，9： | 1 |
| 13 | Valproic acid as epigenetic cancer drug:preclinical,clinical and transcriptional effects on solid tumors显示文摘 | Duenas-Gonzalez A Candelaria M Perez-Plascencia C | 2008 | Cancer Treat Rev2008，34，3： | 1 |
| 14 | Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors 显示文摘 | Duenas-Gonzalez A Candelaria M Perez-Plascencia C | 2008 | Cancer Treat Rev2008，34，3： | 1 |
| 15 | The prognostic signifi- cance of leukocytosis in cervical cancer 显示文摘 | Garcia-Arias A Cetina L Candelaria M | 2007 | Int J Gynecol Cancer2007，17，2： | 1 |
| 16 | A phase Ⅱ study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors显示文摘 | Candelaria M Gallardo RD Arce C | 2007 | Annals of Oncology2007，18，9： | 1 |
| 17 | Maternal perceptions of toddler body size: accuracy and satisfaction' differ by toddler weight status显示文摘 | Hager ER Candelaria M Latta LW | 2012 | Arch Pediatr Adolesc Med2012，166，5： | 1 |
| 18 | Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors 显示文摘 | Duenas-Gonzalez A Candelaria M Perez-Plascencia C | 2008 | Cancer Treat Rev2008，34，3： | 1 |
| 19 | Fault detection and isolation in low-voltage dc-bus microgrid system显示文摘 | PARK J D CANDELARIA J | 2013 | IEEE Transactions on Power Delivery2013，28，2： | 1 |
| 20 | DC ring-bus microgrid fault protection and identification of fault location 显示文摘 | PARK J D CANDELARIA J MA L | 2013 | IEEE Transactions on Power Delivery2013，28，4： | 1 |
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