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| 1 | Comparison of central corneal thickness measurements with three new optical devices and a standard ultrasonic pachymeter显示文摘AIM:To compare the RTVue spectral optical coherence tomography(SD-OCT),Sirius Scheimpflug-Placido topographer,Lenstar optical low coherence reflectometry(OLCR)and ultrasound pachymetry(USP)devices in terms of their agreement and repeatability of measuring central corneal thickness(CCT).METHODS:In this prospective study,50 eyes of 50patients were included.Three repeated measures were obtained using SD-OCT,Scheimpflug-Placido topographer and USP and five measurements were determined with the OLCR.Bland-Altman plots were used to assess agreement among the instruments,and 95%limits of agreement(LoA)for each comparison were calculated.Intra-examiner repeatability was assessed using intraclass correlation coefficients(ICCs).RESULTS:The mean CCT by SD-OCT,ScheimpflugPlacido topographer,OLCR,and USP were 525.90±34.08μm,525.92±34.10μm,530.30±35.62μm,and543.50±37.11μm respectively.All 4 modalities of CCT measurements correlated closely with each other,with Pearson correlation coefficients ranging from 0.977 to0.995.The mean differences(and upper/lower LoA)for CCT measurements were-0.05±6.77μm(13.3/-13.3)between SD-OCT and Scheimpflug-Placido topographer,4.38±3.79μm(11.8/-3.1)between OLCR and SD-OCT,4.38±6.03μm(16.2/-7.5)between OLCR and ScheimpflugPlacido topographer,13.20±6.46μm(25.9/0.5)between USP and OLCR,17.59±6.76μm(30.8/4.3)between USP and SD-OCT,and 17.58±8.13μm(33.5/1.6)between USP and Scheimpflug-Placido topographer.Intra-examiner repeatability was excellent for all devices with ICCs>0.98.CONCLUSION:For most practical purposes,CCT measurements with the RTVue,Sirius and Lenstar can be used interchangeably.Although highly correlated,CCTmeasurement differences between USP and these 3optical instruments can be significant depending on the clinical situation. | Hasan Ali Bayhan Seray Aslan Bayhan Iz.zet Can | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 8 |
| 2 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
| 3 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 4 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 5 | Synthesis, characterization and cytotoxicity of novel modified poly[(maleic anhydride)‐ co ‐(vinyl acetate)]/noradrenaline conjugate显示文摘 | Gulderen Karakus Zubeyde Akin Polat Ali Fazil Yenidunya Haci Bayram Zengin Can Bulent Karakus | 2012 | Polym. Int2012，，3： | 1 |
| 6 | Multilocular cystic nephroma: an unusual localization显示文摘 | Ali Riza Kural Can ?bek Gülsen ?zbay Ali Ulvi ?nder | 1998 | Urology1998，，5： | 1 |
| 7 | Modification oflTO surface using aromatic small molecules with carboxylic acid groups for OLEDapplication 显示文摘 | Ali Kemal Havare Mustafa Can Serafettin Demic | 2011 | Synthetic Metals2011，2122，161： | 1 |
| 8 | Artificial neural networks based on memristive devices显示文摘The advent of memristive devices and the continuing research and development in the field of neuromorphic computing show great potential as an alternative to traditional von Neumann computing and bring us ever closer to realizing a true 'thinking machine'. Novel neural network architectures and algorithms inspired by the brain are becoming more and more attractive to keep up with computing needs,relying on intrinsic parallelism and reduced power consumption to outperform more conventional computing methods. This article provides an overview of various neural networks with an emphasis on networks based on memristive emerging devices, with the advantages of memristor neural networks compared with pure complementary metal oxide semiconductor(CMOS) implementations. A general description of neural networks is presented, followed by a survey of prominent CMOS networks, and finally networks implemented using emerging memristive devices are discussed, along with the motivation for developing memristor based networks and the computational potential these networks possess. | Vignesh RAVICHANDRAN Can LI Ali BANAGOZAR J.Joshua YANG Qiangfei XIA | 2018 | Science China(Information Sciences)2018，61，6： | 1 |
| 9 | The relative distribution of membranous and cytoplasmic Met is a prognostic indicator in stage Ⅰ and Ⅱ colon ancer 显示文摘 | Fiona Ginty Sudeshna Adak Ali Can | 2008 | Clin Cancer Res2008，14，12： | 1 |
| 10 | A novel iso-scallop tool-pathgeneration for efficient five-axis machining of free-formsurfaces 显示文摘 | Ahmet Can Ali Uniivar | 2010 | Int J Adv Manuf Technol2010，51，： | 1 |
| 11 | An experimental investigation of tool wear in electric discharge machining显示文摘 | Ali Ozgedik Can Cogun | 2006 | The International Journal of Advanced Manufacturing Technology2006，27，6： | 1 |
| 12 | Gastrointestinal perforation due to incarcerated Meckel's diverticulum in right femoral canal显示文摘Meckel's diverticulum is a very common congenital anomaly of the gastrointestinal tract but many cases remain asymptomatic and are diagnosed incidentally during laparoscopic or other surgical procedures. Cases of femoral hernia involving Meckel's diverticulum are rare, with less than 50 cases reported in the literature since Littre published the first description of this coincident condition over 300 years ago. While all true 'Littre's hernias' contain a Meckel's diverticulum, the involved anatomical sites are various, the most common being the inner groin(inguinal), the outer groin(femoral), and the belly button(umbilical). Complications of Littre's hernias include incarceration, strangulation, necrosis, and perforation. Herein, we describe a case of Littre's hernia that involved an incarcerated Meckel's diverticulum in a femoral hernia that was diagnosed upon investigation of symptomology manifesting from perforation and was successfully managed by surgical resection with stapler devices. | Yusuf Yagmur Sami Akbulut Mehmet Ali Can | 2014 | World Journal of Clinical Cases2014，2，6： | 1 |
| 13 | Five-axis tool path generation for 3D curves created by projection on B-spline surfaces 显示文摘 | Can Ahmet ttntivar Ali | 2010 | The International Journal of Advanced Manufacturing Tech- nology2010，49，12： | 1 |
| 14 | A novel iso-scallop tool-path generation for efficient five-axis machining of free-form surfaces显示文摘 | Ahmet Can Ali ünüvar | 2010 | The International Journal of Advanced Manufacturing Technology2010，，9： | 1 |
| 15 | A novel iso-scallop too-path gen- eration for efficient five-axis machining of free-form surfaces显示文摘 | Ahmet Can & Ali 13ntivar | 2010 | Int J Adv Manuf Technol2010，，51： | 1 |
| 16 | A Feature Based,Robust,Hierarchical Algorithm for Registering Pairs of Images of the Curved Human Retina显示文摘 | Can Ali Stewert C V Roysam B | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，3： | 1 |
| 17 | Small Bowel Intussusception due to Metastasized Sarcomatoid Carcinoma of the Lung: A Rare Cause of Intestinal Obstruction in Adults显示文摘 | Ali Guner Sava? Karyagar Ayten Livaoglu Can Kece Uzer Kucuktulu A. Cho S. S. Daradkeh I. K. Komenaka F. Marchal G. Melloni | 2012 | Case Reports in Surgery2012，，： | 1 |
| 18 | Drospirenone‐Containing Oral Contraceptives and Risk of Adverse Outcomes After Myocardial Infarction显示文摘 | Can Yucel Karabay Gonenc Kocabay Vecih Oduncu Arzu Kalayci Ahmet Guler Ali Karag?z Ozkan Candan Ozcan Basaran Regayip Zehir Ak?n ?zgi Ali Metin Esen Cevat K?rma | 2013 | Cathet. Cardiovasc. Intervent2013，，： | 1 |
| 19 | Effect of variable friction coefficient on sheet metal drawing 显示文摘 | Haluk Darendeliler Metin Akktik Can Ali Yticesoy | 2002 | Tribology International2002，，2： | 1 |
| 20 | Investigation of the genotype distribution of hepatitis C virus among Turkish population in Turkey and various European countries显示文摘 | Vedat Turhan Nurittin Ardic Can Polat Eyigun Ismail Yasar Avci Ali Sengul Alaaddin Pahsa | 2005 | Chinese Medical Journal2005，，16： | 1 |
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