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| 1 | 常规脂蛋白检测和载脂蛋白在心血管病预测中的比较显示文摘总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。 | Welsh C Celis-Morales CA Brown R Mackay DF Lewsey J Mark PB Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund PS Gill J MR Pell JP Sattar N Welsh P 刘青(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，27，7： | 10 |
| 2 | Management of hepatitis C in patients with chronic kidney disease显示文摘Hepatitis C virus(HCV) infection is highly prevalent among chronic kidney disease(CKD) subjects under hemodialysis and in kidney transplantation(KT) recipients, being an important cause of morbidity and mortality in these patients. The vast majority of HCV chronic infections in the hemodialysis setting are currently attributable to nosocomial transmission. Acute and chronic hepatitis C exhibits distinct clinical and laboratorial features, which can impact on managementand treatment decisions. In hemodialysis subjects, acute infections are usually asymptomatic and anicteric; since spontaneous viral clearance is very uncommon in this context, acute infections should be treated as soon as possible. In KT recipients, the occurrence of acute hepatitis C can have a more severe course, with a rapid progression of liver fibrosis. In these patients, it is recommended to use pegylated interferon(PEG-IFN) in combination with ribavirin, with doses adjusted according to estimated glomerular filtration rate. There is no evidence suggesting that chronic hepatitis C exhibits a more aggressive course in CKD subjects under conservative management. In these subjects, indication of treatment with PEG-IFN plus ribavirin relies on the CKD stage, rate of progression of renal dysfunction and the possibility of a preemptive transplant. HCV infection has been associated with both liver disease-related deaths and cardiovascular mortality in hemodialysis patients. Among those individuals, low HCV viral loads and the phenomenon of intermittent HCV viremia are often observed, and sequential HCV RNA monitoring is needed. Despite the poor tolerability and suboptimal efficacy of antiviral therapy in CKD patients, many patients can achieve sustained virological response, which improve patient and graft outcomes. Hepatitis C eradication before KT theoretically improves survival and reduces the occurrence of chronic graft nephropathy, de novo glomerulonephritis and post-transplant diabetes mellitus. | Roberto J Carvalho-Filho Ana Cristina CA Feldner Antonio Eduardo B Silva Maria Lucia G Ferraz | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 3 | 钾通道J亚家族成员5基因嵌合导致双侧肾上腺皮质增生进而引起的早期原发性醛固酮增多症显示文摘钾通道J亚家族成员5(potassium voltage-gated channel subfamily J member 5,KCNJ5)的体细胞变异最易导致原发性醛固酮增多症(primary aldosteronism,PA),有部分患者因KCNJ5钾通道基因的生殖细胞突变而患该病[家族性醛固酮增多症Ⅲ型(familial hyperaldosteronismⅢ,FH-Ⅲ)]。方法:1998年,美国国立卫生研究院临床中心发现一名11岁的白人男孩,患有早期严重高血压。 | Maria AG Suzuki M Berthon A Kamilaris C Demidowich A Lack J Zilbermint M Hannah-Shmouni F Faucz FR Stratakis CA 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 4 | Mucins MUC1, MUC2, MUC5AC and MUC6 expressin in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma显示文摘 | Pinto-de-Sousa J David L Reis CA | 2002 | Virchows Arch2002，440，3： | 2 |
| 5 | Blue-on-yellow perimetry can predict the development of glaucomatous visual field loss 显示文摘 | Johnson CA Adams A J Gasson E J | 1993 | ArchOphthalmol1993，111，： | 2 |
| 6 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 7 | 体位性低血压的危险因素:老年男女存在差异显示文摘体位性低血压(orthostatic hypotension,OH)一般发生在站立后调节血压水平的机制发生变化以后。目前尚不清楚不同性别间OH的发生率和危险因素有何不同。本文旨在调查老年人OH患病率和危险因素的性别差异。方法:纳入来自委内瑞拉马拉开波老龄化研究的882名参与者。从仰卧位到站立位3 min后,收缩压持续下降≥20和(或)舒张压持续下降≥10 mm Hg(1 mm Hg=0.133 kPa)定义为OH。考虑到性别的交互作用和性别分层,研究者采用多因素Logistic回归模型评估男、女OH危险因素的相关性。 | Méndez AS Melgarejo JD Mena LJ Chávez CA González AC Boggia J Terwilliger JD Lee JH Maestre GE 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 8 | 生长兔日粮中棕榈仁粕的营养价值显示文摘为确定饲料中的棕榈仁粕(PKM)对生长兔的营养价值,在试验1中,选用新西兰×加州50日龄生长兔20只来确定PKM的能量、粗蛋白、纤维和脂肪消化率。通过不同方法对其营养价值进行评估,试验分为对照组(基础日粮)和试验组(在基础日粮中添加PKM200g.kg-1)。PKM的能量、粗蛋白、乙醚提取物和中性洗涤纤维的消化率分别为0.549(±0.056,SE)、0.541(±0.069)、0.850(±0.048)和0.430(±0.101),可消化的能量为10.9±1.03MJ.kg-1DM;试验2中,412只生长兔被随机分配在2个试验日粮组来衡量其增长性能。试验结果表明,与对照组相比,PKM日粮组对饲料及可消化能量的摄入无显著差异,但平均日增重(P=0.003)和饲料效率(P<0.001)略有下降(约5%),死亡率和软粪便中产气荚膜梭菌数量都不受日粮类型的影响。说明棕榈仁粕可以作为生长兔的纤维、蛋白质和脂肪来源,其可以替代其他日粮中大量的纤维成分,并且对生产性能没有不利影响。 | Carrión S De Blas J C Méndez J Caídas A García-Rebollar P | 2012 | 饲料博览2012，，2： | 2 |
| 9 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 10 | Real time quantitativePCR显示文摘 | Heid CA Stevens J Livak K J | | 0，，： | 2 |
| 11 | Review of Epidemiological evidence of health effects of particulate air pollution显示文摘 | Pope CA Doekery DW Sehwarz J | 1995 | Inhalation Toxicology1995，7，1： | 1 |
| 12 | Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology显示文摘 | Mohan VP Scanga CA Yu K Scott HM Tanaka KE Tsang E Tsai MM Flynn JL Chan J | 2001 | Infect Immune2001，69，3： | 1 |
| 13 | Evaluation of colposcopic accuracy in diagnosis of cervical neoplasia显示文摘 | Srisomboon J Tangchaitrong CA Bhusawang Y | 1996 | J Med Assoc Thai1996，79，： | 1 |
| 14 | BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals显示文摘 | Jette CA Flanagan AM Ryan J | 2008 | Cell Death Differ2008，15，6： | 1 |
| 15 | Effectiveness of a modified mother - infant transaction program on outcomes for preterm infants from 3 to 24 months of age 显示文摘 | Newnham CA Milgrom J Skoutefis H | 2009 | Infant Behav Dev2009，32，1： | 1 |
| 16 | Serological response to Cryptosporidium parvum in adult cattle from the Andean region of Colombia显示文摘 | Vergara-Castiblanco CA Quilez-Cinca J Freire-Santos F | 2001 | Parasitol Res2001，87，6： | 1 |
| 17 | Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis显示文摘 | Schedel J Seemayer CA Pap T | 2004 | Gene Ther2004，11，13： | 1 |
| 18 | Competition in vivo between a cytopathic variant and a wild-type duck hepatitis B virus显示文摘 | Lenhoff RJ Luscombe CA Summers J | 1998 | Virology1998，251，： | 1 |
| 19 | Review of strain rate effects for concrete in tension显示文摘 | Malvar L J Ross CA | 1998 | ACI Matreials Journal1998，95，6： | 1 |
| 20 | Plasmatic level of neuroinflammatory markers predict the extent of diffusionweighted image lesions in hyperacute stroke显示文摘 | Montaner J Rovira A Molina CA | 2003 | J Cereb Blood Flow Metab2003，23，： | 1 |
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