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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Two-way coupled fluid structure interaction simulation of a propeller turbine显示文摘 | H Schmucker F Flemming S Coulson | 2010 | IOP Conference Series: Earth and Environmental Science2010，，1： | 2 |
| 3 | Colonization of grassland by sown species: dispersal versus microsite limitation in responses to management显示文摘 | Coulson S J Bullock J M & Stevenson M J | 2001 | Journal of Applied Ecology2001，38，： | 1 |
| 4 | Spatial cueing in time-space synesthetes:An event-related brain potential study显示文摘 | Teuscher U Brang D Ramachandran V.S Coulson S | | 0，，01： | 1 |
| 5 | Complete sequence of bovine mitochondrial DNA conserved features of the mammalian mitochondrial genome 显示文摘 | Anderson S de Bruijn MH Coulson AR | 1982 | J Mol Biol1982，156，4： | 1 |
| 6 | Residential Investment,Non-residential Investment and GDP显示文摘 | Coulson N E Kim M S | 2000 | Real Estate Economics2000，28，2： | 1 |
| 7 | Effect of pressure on processes modelling the Maillard reaction显示文摘 | Isaacs N S Coulson M | 1996 | Journal of Physical Organic Chemistry1996，，9： | 1 |
| 8 | Histopathology of Cryptococcosis and other Fungal Infections in patients with AIDS显示文摘 | Shibuya K Coulson W E Wollman J S | 2001 | In J Infect Dis2001，5，： | 1 |
| 9 | Note on the method of molecular orbitMs显示文摘 | Coulson C A Rushbrooke G S | 1940 | Mathematical Proceedings of the Cambridge Philosophical Society1940，36，2： | 1 |
| 10 | Integrins a2hl and a4bl can mediate SAll rotavirus attachment and entry into cells显示文摘 | Hewish M J Takada Y Coulson B S | 2000 | J Virol2000，74，1： | 1 |
| 11 | DNA sequencing with chain-terminating inhibitors显示文摘 | Sanger F Nicklen S Coulson AR | 1977 | Proc Natl Acad Sci USA1977，74，12： | 1 |
| 12 | Blending and coded meaning, literaland figurative meaning in cognitive semantics 显示文摘 | COULSON S OAKLEY T | 2005 | Journal ofPragmatics2005，，37： | 1 |
| 13 | Super-repellent composite fluoropolymer surfaces显示文摘 | COULSON S R WOODWARD I BADYAL J P S | 2000 | J Phys Chem B2000，104，： | 1 |
| 14 | Complete sequence of bovine mitochondrial DNA:Conserved features of the mammalian mitochondrial genome显示文摘 | Anderson S de Bruijn M H L Coulson A R | 1982 | J Mol Biol1982，156，： | 1 |
| 15 | U-Pb zircon,geochemical and Sr-Nd-Hf isotopic constraints on the age and origin of Early Palaeozoic Ⅰ-type granite from the Tengchong-Baoshan Block,western Yunnan province,SW China显示文摘 | Liu S Hu R Z Gao S Feng C X Huang Z L Lai S C Yuan H L Liu X M Coulson I M Feng G Y Wang T and Qi Y Q | | 0，，： | 1 |
| 16 | Residential Investment, Non -resi- dential Investment and GDP 显示文摘 | Coulson N K Kim M S | 2000 | Real Estate Economics2000，28，2： | 1 |
| 17 | Typing of Human Rotavirus VP4 by an Enzyme Immunoassay Using Monoclonal Antibodies显示文摘 | Coulson B S | 1993 | J Clin Microbiol1993，31，： | 1 |
| 18 | DNA sequencing with chain terminating inhibitors显示文摘 | Sanger F Nicklen S Coulson AR | 1977 | Proc Natl Acad Sci USA1977，74，12： | 1 |
| 19 | Activation and clinical significance of the unolded protein response in breast cancer显示文摘 | SCRIVEN P COULSON S HAINES R | | 0，，10： | 1 |
| 20 | Expect the unexpected:Event-related brain response of morphosyntatic violations显示文摘 | Coulson S J.King M.Kutas | | 0，，： | 1 |
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