| 1 | Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition显示文摘The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis,homeostasis and function.Vascular endothelial growth factor-a(VEGFA)has been commonly recognized as a pro-angiogenic factor in vertebrate developmental,physiological and pathological conditions for decades.Here we report a novel finding that genetic ablation of CDP-diacylglycerol synthetase-2(CDS2),a metabolic enzyme that controls phosphoinositide recycling,switches the output of VEGFA signaling from promoting angiogenesis to unexpectedly inducing vessel regression.Live imaging analysis uncovered the presence of reverse migration of the angiogenic endothelium in cds2 mutant zebrafish upon VEGFA stimulation,and endothelium regression also occurred in postnatal retina and implanted tumor models in mice.In tumor models,CDS2 deficiency enhanced the level of tumorsecreted VEGFA,which in-turn trapped tumors into a VEGFA-induced vessel regression situation,leading to suppression of tumor growth.Mechanistically,VEGFA stimulation reduced phosphatidylinositol(4,5)-bisphosphate(PIP2)availability in the absence of CDS2-controlled-phosphoinositide metabolism,subsequently causing phosphatidylinositol(3,4,5)-triphosphate(PIP3)deficiency and F0X01 activation to trigger regression of CDS2-null endothelium.Thus,our data indicate that the effect of VEGFA on vasculature is context-dependent and can be converted from angiogenesis to vascular regression. | Wencao Zhao Le Cao Hanru Ying Wenjuan Zhang Dantong Li Xiaolong Ziiu Wenzhi Xue Shuang Wu Mengye Cao Cong Fu Haonan Qi Yimei Hao Yun-Chi Tang Jun Qin Tao PZhong Xiaoxi Lin Luyang Yu Xuri Li Lin Li Dianqing Wu Weijun Pan | 2019 | Cell Research2019，29，11： | 9 |
| 2 | Community characteristics of macrobenthos in the Huanghe(Yellow River) Estuary during water and sediment discharge regulation显示文摘The community characteristics of macrobenthos in the Huanghe(Yellow River) Estuary is influenced by a combination of natural and anthropogenic factors. Here, we investigated short-term changes(1-month) in macrobenthic community structure in response to water and sediment discharge regulation(WSDR) in 2011.Specifically, we sampled the macrobenthos at 18 sampling stations situated at four distances(5, 10, 20, and 40 km)from the mouth of the Huanghe Estuary before(mid-June), during(early-July), and after(mid-July) WSDR. The results showed that a total of 73, 72, and 85 species were collected before, during, and after WSDR, respectively.Then, 13, 1, and 16 dominant species were detected at this three periods. Four phyla were primarily detected at all three periods(Annelida, Mollusca, Arthropoda, and Echinodermata). However, while Mollusca and Annelida were the most important phyla in our study, Echinodermata and Annelida were the most important phyla in 1982,demonstrating major changes to community structure over a 3-decadal period. All stations were of high quality BOPA index before WSDR, whereas two and three stations were of reduced quality BOPA index during and after WSDR, respectively. The results of ABC curves showed that had incurred disturbed conditions after human activities WSDR. Most important of all, multivariate analyses and RDA analysis indicated that the structure of the macrobenthic community was closely linked to environment factors, including that organic content factor caused the distribution of macrobenthic community mostly during WSDR, while water depth after WSDR affected the macro benthos community structure seriously, and during WSDR, the environment factor influencing it was not single, including organic content, sulfide content, Hg and As. These differences may have been due to changes in water transparency negatively impacting the growth and development of macrobenthos, due to specific lifehistory requirements. Our results demonstrate that anthropogenic activity is having both long-term(3 decadal)and short term(1-month) impacts on the structure of the macrobenthic community of the Huanghe Estuary. In conclusion, human activities WSDR influence the habitat environment of macro benthos, including the water temperature, nutrients, bioturbation, and so on. Therefore, we suggest the necessity to strengthen regulations of land-derived organic pollutant input to maintain the ecological balance of the Huanghe Estuary. | REN Zhonghua LI Fan WEI Jiali LI Shaowen LV Zhenbo GAO Yanjie CONG Xuri | 2016 | Acta Oceanologica Sinica2016，35，8： | 2 |
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