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| 1 | Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection显示文摘Chemokines produced in the liver during hepatitis C virus(HCV) infection induce migration of activated T cells from the periphery to infected parenchyma.The milieu of chemokines secreted by infected hepatocytes is predominantly associated with the T-helper cell/Tc1 T cell(Th1/Tc1) response.These chemokines consist of CCL3(macrophage inflammatory protein-1α;MIP-1α),CCL4(MIP-1β),CCL5(regulated on activation normal T cell expressed and secreted;RANTES),CXCL10(interferon-γ-inducible protein-10;IP-10),CXCL11(interferon-inducible T-cell α chemoattractant;I-TAC),and CXCL9(monokine induced by interferon γ;Mig) and they recruit T cells expressing either CCR5 or CXCR3 chemokine receptors.Intrahepatic and peripheral blood levels of these chemokines are increased during chronic hepatitis C.The interaction between chemokines and their receptors is essential in recruiting HCV-specific T cells to control the infection.When the adaptive immune response fails in this task,non-specific T cells without the capacity to control the infection are also recruited to the liver,and these are ultimately responsible for the persistent hepatic damage.The modulation of chemokine receptor expression and chemokine secretion could be a viral escape mechanism to avoid specific T cell migration to the liver during the early phase of infection,and to maintain liver viability during the chronic phase,by impairing non-specific T cell migration.Some chemokines and their receptors correlate with liver damage,and CXCL10(IP-10) and CXCR3 levels have shown a clinical utility as predictors of treatment response outcome.The regulation of chemokines and their receptors could be a future potential therapeutic target to decrease liver inflammation and to increase specific T cell migration to the infected liver. | Juan R Larrubia Selma Benito-Martínez Miryam Calvino Eduardo Sanz-de-Villalobos Trinidad Parra-Cid | 2008 | World Journal of Gastroenterology2008，14，47： | 13 |
| 2 | Comparison of ischemia - modified albumin levels in patients undergoing percutaneous coronary interven- tion for unstable angina pectoris with versus without coronary collater- als显示文摘 | Garrido IP Roy D Calvino R | 2004 | Am J Cardiol2004，93，1： | 1 |
| 3 | Comparison of ischemia-modified albumin levels in patients undergoing precutaneous coronary interven- tion for unstable angina pectoris with versus without coronary collater- als 显示文摘 | Garrido IP Roy K Calvino R | 2004 | Am J Cardiol2004，93，1： | 1 |
| 4 | Effects of balloon occlusion during percutaneous coronary intervention on circulating ischemia modified albumin and transmyocardial lactate extraction 显示文摘 | Sinha MK Vazquez JM Calvino R | 2006 | Heart2006，92，12： | 1 |
| 5 | Comparison of ischemia modified albumin levels in patients undergoing percutaneons coronany intervention for unstable angina pectoris with versus coronary collaterals显示文摘 | GARRIDO I P ROY D CALVINO R | 2004 | Am J Cardiol2004，93，： | 1 |
| 6 | The role of CCR5/ CXCR3 expressing CD8^+ cells in liver damage and viral control during persistent hepatitis C virus infection显示文摘 | Larruhia J R Calvino M Benito S | 2007 | J Hepatol2007，47，： | 1 |
| 7 | Plasma immunoactive endothelin concentration correlates with severity of coronary artery disease in patients with stable angina pectoris anf normal ventricular function显示文摘 | Elliott PM Calvino R | 1996 | J Am Coll Cardio1996，28，： | 1 |
| 8 | Comparison of ischemia-modified albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without eornnary collaterals显示文摘 | Garrido IP Roy D Calvino R | 2004 | Am J Cardiol2004，93，1： | 1 |
| 9 | Comparison of ischemia modified albumin levels in patients undergoing pertcutaneous coroary intervention for unstable angina peetoris with versus without coronary collaterals pectoris with versus without coronary collaterals 显示文摘 | Garrido IP Roy D Calvino R | 2004 | Am J Cardiol2004，93，1： | 1 |
| 10 | Comparison of ischemia-modified albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals显示文摘 | Garrido IP Roy D Calvino R | 2004 | Am J Cardiol2004，93，4： | 1 |
| 11 | Plasma immunoactive endothelin concentration correlates with severity of coronary artery disease in patients with stable angina pectoris and normal ventricular function显示文摘 | Salmone OA Elliotte PM Calvino R | 1996 | J Am Coll Cardiol1996，28，1： | 1 |
| 12 | Comparison of ischemia modified albumin levels in patients undergoing pereutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals pectoffs with versus without coronary collateals显示文摘 | Garrido IP Roy D Calvino R | 2004 | Am J Cardiol2004，93，1： | 1 |
| 13 | Comparison of ischemia-modified albumin levels in patients undergoing precutaneous coronary intervenetion for unstable angina pectoris with versus without coronary collaterals显示文摘 | Garrido IP Roy K Calvino R | 2004 | Am J Cardiol2004，93，1： | 1 |
| 14 | Comparison of two dimensional echocardiography and pulsed doppler tissue imaging during dobutamine-atropine stress testing detect coronary artery disease显示文摘 | Peteiro J Monserrat L Fabregas R Manuel J Calvino R Castro A | 2001 | Echocardiography2001，18，4： | 1 |
| 15 | Effects of balloon occlusion during percutaneous coronary intervention on circulating Ischemia Modified Albumin and transmyocardial lactate extraction显示文摘 | Sinha MK Vazquez JM Calvino R | 2006 | Heart2006，92，12： | 1 |
| 16 | Transradial approach to coronary angiography and angioplasty,initial experience and learning curve显示文摘 | Salgade Femande J Calvino Santos R Vazqucz Rodriguez JM | 2003 | Rev Esp Cardiol2003，56，1： | 1 |
| 17 | The role of CCRS/CXCR3 expressing CD8 + cells in liver damage and viral control during persistent hepatitis C virus infection显示文摘 | LARRUBIA J R CALVINO M BENITO S | 2007 | J Hepatol2007，47，5： | 1 |
| 18 | Comparison of ischemiamodified albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals显示文摘 | Garrido I P Roy D Calvino R | 2004 | Am J Cardiol2004，93，1： | 1 |
| 19 | Contrast-induced nephropathy and acute renal failure following urgent cardiac catheterization:incidence,risk factors and prognosis显示文摘 | Bouxas Mosquera A Vazquez Rodriguez J M Calvino Santos R | | 0，，10： | 1 |
| 20 | Ion interaction reagent reversed-phase high-performance liquid chromatography determination of anti-tuberculosis drugs and metabolites in biological fluids 显示文摘 | Gennaro M C Calvino R Abrigo C | 2001 | J Chromatogr B Biomed Sci Appl2001，754，2： | 1 |
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