|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 3 | Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA dama~induced by the kidney carcinogen KBrO3显示文摘 | CADENAS S BARJA G | 1999 | Free Rasic Biol Med1999，26，1112： | 1 |
| 4 | Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis显示文摘 | Boyd C S Cadenas E | 2002 | Jour- nal of Biological Chemistry2002，383，34： | 1 |
| 5 | The impact of disease activity on the quality of life,mental health status,and family dysfunction in colombian patients with rheumatoid arthritis显示文摘 | CADENA J VINACCIA S P(E)REZ A | 2003 | J Clin Rheumatol2003，9，3： | 1 |
| 6 | Resistance exer- cise increases AMPK activity and reduces 4E - BP1 phos- phorylation and protein synthesis in human skeletal mus- cle 显示文摘 | Dreyer H C Fujita S Cadenas J G | 2006 | J Physiol2006，576，2： | 1 |
| 7 | Calprotectin:a novel biomarker for the diagnosis of pleural effu- sion 显示文摘 | Sdnchez-Otero N Blanco-Prieto S Paez dela Cadena M | 2012 | Br J Cancer2012，107，11： | 1 |
| 8 | Glycerophospholipid profile in oncogene-induced senescence显示文摘 | Cadenas C Vosbeck S Hein EM | 2012 | Biochim Biophys Acta2012，1821，9： | 1 |
| 9 | Resistance exercise increases AMPK activity and reduces 4E BP1 phos- phorylation and protein synthesis in human skeletal muscle显示文摘 | DREYER H C FUJITA S CADENAS J G | 2006 | J Physiol2006，576，2： | 1 |
| 10 | Resistance exercise increases AMPK activity and reduces 4E-BP1 phos- phorylation and protein synthesis in human skeletal muscle显示文摘 | DREYER H C FUJITA S CADENAS J G | 2006 | J Physiol2006，，2： | 1 |
| 11 | The Impact of Dis- ease Activity on the Quality of Life, Mental Health Status, And Family Dysfunction in Colombian Patients with Rheumatoid Arthriti显示文摘 | Cadena J Vinaccia S P6rez A | 2003 | J Clin Rheuma- tol2003，9，3： | 1 |
| 12 | Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long - lived species: the pigeon and human case显示文摘 | PAMPLONA R PRAT J CADENAS S | 1996 | Mech Ageing Dev1996，86，： | 1 |
| 13 | Biofuels as sustainable technologies:perspectives for less developed countries显示文摘 | Cadenas A Cabezudo S | 1998 | Technol Forecast SocialChange1998，58，1： | 1 |
| 14 | Regulation of hypoxia- inducible factor-lalpha by nitric oxide through mitochondria-dependent and -independent pathways显示文摘 | Mateo J Garcia-Lecea M Cadenas S | 2003 | Bioehem2003，376，： | 1 |
| 15 | Sensory analysis: relevance for prebiotic, probiotic, and synbiot- ic product development 显示文摘 | Cruz A G Cadena R S Walter E H M | 2010 | Comprehensive Reviews in Food Science and Food Safety2010，9，4： | 1 |
| 16 | Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis显示文摘 | Boyd C S Cadenas E | 2002 | Biol Chem2002，383，34： | 1 |
| 17 | The impact of disease activity on the quality of life, mental health status, and family dysfunction in colombian patients with rheumatoid arthritis 显示文摘 | Cadena J Vinaccia S P6rez A | 2003 | J Clin Rheumatol2003，9，3： | 1 |
| 18 | Consumer perception of probiotic yogurt: performance of check all that apply (CATA), projective mapping, sorting and intensity scale 显示文摘 | A G Cruz R S Cadena W F Castro | 2013 | Food Research International2013，1，54： | 1 |
| 19 | Using a Clinical Collaborative Model for Nursing Education: Application for Clinical Teaching显示文摘 | Maguire D J Zambroski C H Cadena S V | 2012 | Nurse Educ2012，37，2： | 1 |
| 20 | Glucose deprivation induces reticulum stress bythe PERK pathway and caspase - 7 - and calpain - mediatedcaspase - 12 activation显示文摘 | DE LA CADENA S G HERNANDEZ FONSECA K CAMACHOARROYO I | 2014 | Apoptosis2014，19，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员