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| 1 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 3 | Overview of antifungal agents显示文摘 | Thompson GR Cadena J Patttersun TF | 2009 | Clin Chest Med2009，30，2： | 1 |
| 4 | Mitochondrial free radical generation, oxidative stress ,and aging显示文摘 | Cadenas E Davies K J | 2000 | Free Radic Biol Med2000，29，： | 1 |
| 5 | Solving fuzzy optimization problems by evolutionary algorithms 显示文摘 | F Fimenez J M Cadenas J L Verdegay | 2003 | Information Sciences (S0020-0255)2003，，152： | 1 |
| 6 | Direct analysis of abscisic acid in crude plant extracts by liquid spray/tandem mass spectrometry 显示文摘 | GOMEZ- CADENAS A POZO O J GARCIA - AU- GUSTIN P | 2002 | Phytochem Anal2002，13，4： | 1 |
| 7 | Redox cycles of caffeic acid,a-tocopherol, and ascorbate: implications for protection of low-density lipoproteins against oxidation 显示文摘 | Laranjinha J Cadenas E | 1999 | IUBMB Life1999，48，： | 1 |
| 8 | Using ranking functions in multiobjective fuzzy linear programming显示文摘 | Cadenas J M Verdegay J | 2000 | FSS2000，111，： | 1 |
| 9 | The impact of disease activity on the quality of life,mental health status,and family dysfunction in colombian patients with rheumatoid arthritis显示文摘 | CADENA J VINACCIA S P(E)REZ A | 2003 | J Clin Rheumatol2003，9，3： | 1 |
| 10 | Resistance exer- cise increases AMPK activity and reduces 4E - BP1 phos- phorylation and protein synthesis in human skeletal mus- cle 显示文摘 | Dreyer H C Fujita S Cadenas J G | 2006 | J Physiol2006，576，2： | 1 |
| 11 | Resistance exercise increases AMPK activity and reduces 4E BP1 phos- phorylation and protein synthesis in human skeletal muscle显示文摘 | DREYER H C FUJITA S CADENAS J G | 2006 | J Physiol2006，576，2： | 1 |
| 12 | Mitochondrial free radical genera- tioN, oxidative stress, and aging显示文摘 | Cadenas E Davle K J | 2000 | Free radic Biol Med2000，29，： | 1 |
| 13 | Resistance exercise increases AMPK activity and reduces 4E-BP1 phos- phorylation and protein synthesis in human skeletal muscle显示文摘 | DREYER H C FUJITA S CADENAS J G | 2006 | J Physiol2006，，2： | 1 |
| 14 | The Impact of Dis- ease Activity on the Quality of Life, Mental Health Status, And Family Dysfunction in Colombian Patients with Rheumatoid Arthriti显示文摘 | Cadena J Vinaccia S P6rez A | 2003 | J Clin Rheuma- tol2003，9，3： | 1 |
| 15 | Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long - lived species: the pigeon and human case显示文摘 | PAMPLONA R PRAT J CADENAS S | 1996 | Mech Ageing Dev1996，86，： | 1 |
| 16 | Overview of antifungal agents显示文摘 | Thompson GR 3rd Cadena J Patterson TF | 2009 | Clin Chest Med2009，30，2： | 1 |
| 17 | Analysis of ILIB, TAPI, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis 显示文摘 | Gomez LM Camargo JF Castiblanco J Ruiz-Narvaez EA Cadena J Anaya JM | 2006 | Tissue Antigens2006，67，4： | 1 |
| 18 | Why is CO2 so soluble in imidazolium-based ionic liquids显示文摘 | Cadena C Anthony J L Shah J K | 2004 | Journal of American Chemical Society2004，126，16： | 1 |
| 19 | Antibiotic cycling to decrease bacterial antibiotic resistance : a 5-year experience on a bone marrow transplsplant unit 显示文摘 | Cadena J Tabouda CA Burgess DS | 2007 | Bone Marrow Transplantation2007，40，2： | 1 |
| 20 | Treatment of shaft fractures in children with elastic titanium nails 显示文摘 | Mendoza-Balta R J Bello-Gonz lez A Rosas Cadena JL | 2009 | Acta Ortop Mex2009，23，5： | 1 |
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